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DRUGS & SUPPLEMENTS
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Proxalin Plus
When are you taking this medicine? |
Proxalin Plus uses
Proxalin Plus consists of Acetaminophen, Naproxen.Acetaminophen:
Pharmacological action
Proxalin Plus is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Why is Proxalin Plus (Acetaminophen) prescribed?
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Proxalin Plus dosage and administration
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Proxalin Plus side effects, adverse reactions
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Contraindications
Chronic active alcoholism, increased sensitivity to Proxalin Plus, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Using during pregnancy and breastfeeding
Proxalin Plus (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Proxalin Plus (Acetaminophen) on the fetus in humans.
Proxalin Plus (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Proxalin Plus (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Proxalin Plus (Acetaminophen).
Special Instructions
Proxalin Plus is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Proxalin Plus (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
Proxalin Plus (Acetaminophen) Drug Interactions
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Proxalin Plus (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Proxalin Plus (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Proxalin Plus (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Proxalin Plus (Acetaminophen).
When Proxalin Plus (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Proxalin Plus (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Proxalin Plus (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Proxalin Plus (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Proxalin Plus (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Proxalin Plus (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Proxalin Plus (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Proxalin Plus (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Proxalin Plus (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Proxalin Plus (Acetaminophen) with ethinylestradiol increases absorption of Proxalin Plus (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Proxalin Plus in case of emergency / overdose
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Naproxen:
Proxalin Plus information
Proxalin Plus (Naproxen) is an anti-inflammatory non-steroidal anti-inflammatory (NSAID) medicine. Proxalin Plus (Naproxen) Actavis's actions help reduce the chemicals found in the patient's organism that are usually responsible for the triggering of inflammation and pain.
Proxalin Plus indications
Proxalin Plus (Naproxen) is a drug normally prescribed in the treatment of pain, stiffness or inflammation that are usually triggered by medical disorders such as Gout, Osteoarthritis, menstruation abdominal cramps, rheumatoid arthritis, ankylosing spondylitis, injury, buritis and tendonitis.
Proxalin Plus (Naproxen) could also be prescribed in the treatment of other medical conditions that have not been mentioned here.
Proxalin Plus warnings
While the patient is following a treatment with Proxalin Plus (Naproxen) Actavis, he or she should avoid consuming big amounts of alcohol. It is recommended that alcohol drinks should be entirely avoided as they increase the danger of stomach bleeding. Therefore, if the patient is consuming more than 3 bottles of different alcoholic beverages he or she might not be allowed to start a treatment with Proxalin Plus (Naproxen) Actavis.
Proxalin Plus (Naproxen) can lead to drowsiness and dizziness. If you are following a treatment with this drug you should be careful while performing actions that require mental and physical alertness. The treatment with Proxalin Plus (Naproxen) should be carefully monitored in the case of patients suffering from any of the next medical disorders:
Allergic reactions to Aspirin (or any other NSAIDs)
Bleeding disorder
Liver problems
High blood pressure
Heart failure
Congestive heart disease
Fluid retention
Ulcer
Kidney disease
Stomach bleeding
If you are suffering from any of these medical disorders you might not be allowed to start a treatment with Proxalin Plus (Naproxen) Actavis.
Proxalin Plus (Naproxen) is a Category B FDA pregnancy drug. Therefore it is not considered to be harmful to an unborn child. However, if you are pregnant, consult with your doctor before starting a treatment with Proxalin Plus (Naproxen) Actavis. Proxalin Plus (Naproxen) (one of Proxalin Plus (Naproxen) Actavis's main ingredients) can pass into breast milk. If you are nursing an infant you should consult with your doctor before starting a treatment with Proxalin Plus (Naproxen) Actavis.
Proxalin Plus intake guidelines
Proxalin Plus (Naproxen) ought to be taken in just like your doctor told you to. Do not disobey the physician's instructions.
You should accompany each dose of the drug with a glass of water (from 6 to 8 ounces of liquid). Do not take Proxalin Plus (Naproxen) on an empty stomach as it can cause stomach upset. Do not stop your treatment with this drug without your doctor's consent even if you do not feel better after a few days of treatment.
Proxalin Plus dosage
Ask your doctor to calculate the dose of Proxalin Plus (Naproxen) that suits you best. The correct dosage varies from one person to another, as it depends on a couple of factors.
Proxalin Plus overdose
Reported Proxalin Plus (Naproxen) overdose symptoms are:
Nausea
Excessive sweating
Vomiting
Tingling sensation in legs and arms
Blurred vision
No or little urine production
Shallow and slow breathing
Stomach pains
Numbness
Ringing in the ears
If you are experiencing any of the symptoms listed here, you are in need of medical attention (inform your doctor immediately).
Proxalin Plus missed dose
Proxalin Plus (Naproxen) can be taken in when you need it or on a regular basis. If you are following a treatment with Proxalin Plus (Naproxen) Actavis, try not to miss any of your doses. If you happen to miss one take it as soon as possible. If it is almost time for another dose, skip the one that you have missed and continue with your regular schedule. You should not take in a double dose of this drug.
Proxalin Plus side effects
Very serious side effects of Proxalin Plus (Naproxen) are bloody vomit or bloody stools.
Other dangerous side effects of Proxalin Plus (Naproxen) are:
Allergic reactions (difficulty while breathing, throat closing, hives, swelling of mouth, lips and tongue).
Tingling
Muscle cramps
Mouth ulcers
Numbness
Fluid retention
Jaundice
Ringing in the ears
Stomach cramps or stomach upsets, indigestion or heartburn
Other side effects of the drug are:
Dizziness
Nausea
Headache
Fatigue
Depression
Dry mouth
Weakness
Irregular menstruation
There are other mild side effects that can also occur if you are taking Proxalin Plus (Naproxen) Actavis. Inform your physician if you feel anything disturbing or unusual.
Proxalin Plus drug reactions
You should inform your doctor if you are following a treatment with any of the drugs listed here:
Aspirin
NSAIDs
Cold and cough medicines
Steroids (like prednisone)
Anti coagulants
Insulin
Lithium
Probenecid
Pepto-Bismol
If you are taking any of these drugs you may not be allowed to start taking Proxalin Plus (Naproxen) Actavis. Ask for your doctor's advice before you start a treatment with this drug.
Proxalin Plus pharmaceutical active ingredients containing related brand and generic drugs:
Proxalin Plus available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.