Prizma is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Prizma is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Prizma apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Prizma does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.
Pharmacokinetics
Prizma absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Prizma easily penetrates through the BBB.
Prizma metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.
T1/2 of Prizma is 2-3 days, norfluoxetine - 7-9 days.
Why is Prizma prescribed?
Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.
Dosage and administration
The initial dose of Prizma is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.
Other: pain in joints and muscles, shortness of breath, increased body temperature.
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Prizma contraindications
Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Prizma.
Using during pregnancy and breastfeeding
Prizma is contraindicated during pregnancy and lactation.
Special instructions
Prizma should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.
Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Prizma increases the risk of epileptic seizures.
With the simultaneous application of Prizma and electroconvulsive therapy may develop prolonged seizures.
Prizma can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Prizma before therapy MAO inhibitors should not be less than 5 weeks.
Elderly patients need correction of dosing regimen.
Safety of Prizma in children has not been established.
During the period of treatment it needed to avoid use alcohol.
During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.
Prizma drug interactions
Simultaneous administration of Prizma with:
drugs providing a depressing effect on the central nervous system and with ethanol it is possibly significantly increased inhibitory action on the CNS, as well as increasing the likelihood of developing seizures;
MAO inhibitors, furazolidone, procarbazine, tryptophan may develop serotonin syndrome ;
Prizma inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, thereby increasing their concentration in serum, increase their therapeutic and side effects;
it is possible inhibition of the biotransformation of drugs metabolized with the participation of isoenzyme CYP2D6;
hypoglycemic agents may increase their activities;
haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, pyrathiazine, pimozide, risperidone, sulpiride, trifluoperazine there were describes cases of extrapyramidal symptoms and dystonia; with dextromethorphan - described a case of hallucinations; with digoxin - the case of increasing the concentration of digoxin in plasma;
with lithium salts may increase or decrease the concentration of lithium in blood plasma;
may increase the concentration of imipramine and desipramine in plasma is 2-10 times (and may persist for 3 weeks after discontinuation of Prizma Sanis Health);
propofol there was described a case in which spontaneous movements were observed; with phenylpropanolamine - described a case in which were observed dizziness, weight loss, hyperactivity;
may increase the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol. There are reports on the strengthening effects of warfarin in its simultaneous application with Prizma.
Prizma in case of emergency / overdose
Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Prizma (in combination with maprotiline, codeine, temazepam).
Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.
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Prizma pharmaceutical active ingredients containing related brand and generic drugs:
Can i drive or operate heavy machine after consuming Prizma?
Depending on the reaction of the Prizma after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Prizma not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Prizma addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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Review
sdrugs.com conducted a study on Prizma, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Prizma consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.
Visitor reports
Two visitors reported useful
How is the drug Prizma useful in reducing or relieving the symptoms? How useful is it? According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors
%
Useful
1
50.0%
Not useful
1
50.0%
Visitor reported side effects
No survey data has been collected yet
Visitor reported price estimates
No survey data has been collected yet
Seven visitors reported frequency of use
How often in a day do you take the medicine? Are you taking the Prizma drug as prescribed by the doctor? Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Prizma is mentioned below.
Visitors
%
Once in a day
5
71.4%
Twice in a day
1
14.3%
4 times in a day
1
14.3%
Five visitors reported doses
What is the dose of Prizma drug you are taking? According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors
%
11-50mg
3
60.0%
501mg-1g
1
20.0%
1-5mg
1
20.0%
Five visitors reported time for results
What is the time duration Prizma drug must be taken for it to be effective or for it to reduce the symptoms? Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 3 days to notice the result from using Prizma drug. The time needed to show improvement in health condition after using the medicine Prizma need not be same for all the users. It varies based on other factors.
Visitors
%
3 days
3
60.0%
> 3 month
1
20.0%
3 month
1
20.0%
One visitor reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Prizma drug, before food or after food? Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors
%
After food
1
100.0%
Ten visitors reported age
Visitors
%
6-15
3
30.0%
16-29
3
30.0%
> 60
2
20.0%
46-60
1
10.0%
< 1
1
10.0%
Visitor reviews
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