Pravastatin

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Pravastatin uses


Pravastatin is a cholesterol-lowering agent that belongs to a class of medications known as statins. It was derived from microbial transformation of mevastatin, the first statin discovered. It is a ring-opened dihydroxyacid with a 6’-hydroxyl group that does not require in vivo activation. Pravastatin is one of the lower potency statins; however, its increased hydrophilicity is thought to confer advantages such as minimal penetration through lipophilic membranes of peripheral cells, increased selectivity for hepatic tissues, and a reduction in side effects compared with lovastatin and simvastatin.

Indication: For the treatment of hypercholesterolemia and to reduce the risk of cardiovascular disease.

The primary cause of cardiovascular (CV) disease is atherosclerotic plaque formation and sustained elevation of cholesterol in the blood increases the risk of CV disease. Pravastatin lowers hepatic production of cholesterol by competitively inhibiting HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in the cholesterol biosynthesis pathway via the mevalonic acid pathway. Decreased hepatic cholesterol levels causes increased uptake of low density lipoprotein (LDL) cholesterol and reduces cholesterol levels in the circulation. Pravastatin also inhibits hepatic synthesis if VLDL. At therapeutic doses, Pravastatin lowers LDL cholesterol by 20-30%, increase high density lipoprotein (HDL) cholesterol by 3-10%, and decrease plasma triglycerides by 19-34%. HDL cholesterol is thought to confer protective effects against CV disease, whereas high LDL and triglyceride levels are associated with higher risk of disease.

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Pravastatin pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Pravastatin available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Apo-Pravastatin 10 mg Tablet1.0 USD
Apo-Pravastatin 20 mg Tablet1.18 USD
Apo-Pravastatin 40 mg Tablet1.42 USD
Co Pravastatin 10 mg Tablet1.0 USD
Co Pravastatin 20 mg Tablet1.18 USD
Co Pravastatin 40 mg Tablet1.42 USD
Jamp-Pravastatin 10 mg Tablet1.0 USD
Jamp-Pravastatin 20 mg Tablet1.18 USD
Jamp-Pravastatin 40 mg Tablet1.42 USD
Mint-Pravastatin 10 mg Tablet1.0 USD
Mint-Pravastatin 20 mg Tablet1.18 USD
Mint-Pravastatin 40 mg Tablet1.42 USD
Mylan-Pravastatin 10 mg Tablet1.0 USD
Mylan-Pravastatin 20 mg Tablet1.18 USD
Mylan-Pravastatin 40 mg Tablet1.42 USD
Novo-Pravastatin 10 mg Tablet1.0 USD
Novo-Pravastatin 20 mg Tablet1.18 USD
Novo-Pravastatin 40 mg Tablet1.42 USD
Pms-Pravastatin 10 mg Tablet1.0 USD
Pms-Pravastatin 20 mg Tablet1.18 USD
Pms-Pravastatin 40 mg Tablet1.42 USD
Pravachol 10 mg tablet1.0 USD
Pravachol 20 mg tablet1.18 USD
Pravachol 40 mg tablet1.42 USD
Pravachol 80 mg tablet6.53 USD
Pravastatin sodium 10 mg tablet3.28 USD
Pravastatin sodium 20 mg tablet3.33 USD
Pravastatin sodium 40 mg tablet4.89 USD
Pravastatin sodium 80 mg tablet4.89 USD
Ran-Pravastatin 10 mg Tablet1.0 USD
Ran-Pravastatin 20 mg Tablet1.18 USD
Ran-Pravastatin 40 mg Tablet1.42 USD
Ratio-Pravastatin 10 mg Tablet1.0 USD
Ratio-Pravastatin 20 mg Tablet1.18 USD
Ratio-Pravastatin 40 mg Tablet1.42 USD
Sandoz Pravastatin 10 mg Tablet1.0 USD
Sandoz Pravastatin 20 mg Tablet1.18 USD
Sandoz Pravastatin 40 mg Tablet1.42 USD
Tablets; Oral; Pravastatin Sodium 10 mg
Tablets; Oral; Pravastatin Sodium 20 mg
Tablets; Oral; Pravastatin Sodium 40 mg
Tablets; Oral; Pravastatin Sodium 80 mg

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Pravastatin destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Pravastatin Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Pravastatin pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."PRAVASTATIN SODIUM TABLET [TEVA PHARMACEUTICALS USA INC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "pravastatin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "pravastatin". http://www.drugbank.ca/drugs/DB0017... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Pravastatin?

Depending on the reaction of the Pravastatin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Pravastatin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Pravastatin addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Pravastatin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Pravastatin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

One visitor reported price estimates

What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Pravastatin is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
Visitors%
Expensive1
100.0%

Two visitors reported frequency of use

How often in a day do you take the medicine?
Are you taking the Pravastatin drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Pravastatin is mentioned below.
Visitors%
Once in a day2
100.0%

Visitor reported doses

No survey data has been collected yet

Visitor reported time for results

No survey data has been collected yet

Visitor reported administration

No survey data has been collected yet

One visitor reported age

Visitors%
> 601
100.0%

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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