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PMS-Amantadine uses

Pharmacological action

PMS-Amantadine is an antiparkinsonian and antiviral drug, a tricyclic symmetric adamantanamin.

This medication blocks glutamate NMDA-receptors, thus reducing the excessive stimulatory effect of cortical glutamate neurons in the neostriatum that develops against the backdrop of lack of dopamine. PMS-Amantadine inhibits NMDA-receptors in the neurons of the substantia nigra reduces the intake of these Ca2+, which reduces the possibility of destruction of these neurons. In a greater PMS-Amantadine influences on stiffness.

This medicine inhibits the penetration of influenza A virus into the cell.


PMS-Amantadine after oral administration is completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved after 5 hours. This medication excreted in urine. T1/2 of PMS-Amantadine sulfate is 12-13 hours, in contrast to PMS-Amantadine hydrochloride, which T1/2 is 30 hours.

Why is PMS-Amantadine prescribed?

Parkinson's disease, Parkinson's syndrome.

Neuralgia in Herpes Zoster, caused by the virus Varicella Zoster.

Prevention (including in combination with vaccination) and treatment of influenza A.

Dosage and administration

For oral administration the single dose is 100-200 mg.

IV in the form of infusion in 200 mg during 3 hours.

The frequency and duration of PMS-Amantadine use depends on the evidence, the patient's response to treatment, the epidemiological situation.

The maximum dose for oral administration is 600 mg / day.

PMS-Amantadine side effects, adverse reactions

CNS: headaches, depression, visual hallucinations, motor or mental excitement, convulsions, irritability, dizziness, sleep disturbances, tremors, mental disorders are accompanied by visual hallucinations, reduced visual acuity.

Cardiovascular system: the development or exacerbation of heart failure, orthostatic hypotension; rarely - arrhythmia, tachycardia.

Digestive system: rarely - anorexia, nausea, constipation, dry mouth.

Urinary system: patients with benign prostatic hyperplasia - difficulty urinating; polyuria, nocturia.

Dermatological reactions: dermatitis, the appearance of a bluish color of the skin of the upper and lower extremities.


PMS-Amantadine contraindications

Hepatic failure, chronic renal failure, psychosis (including history), hyperthyroidism, epilepsy, angle-closure glaucoma, prostatic hyperplasia, hypotension, congestive heart failure stage II-III, excited, preddeliry, delirious psychosis, I trimester of pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, increased sensitivity to PMS-Amantadine.

Using during pregnancy and breastfeeding

The use of PMS-Amantadine in pregnancy is possible only under strict indications and under the supervision of a physician.

If necessary to use during lactation it been should decide on the termination of breastfeeding.

Category of the fetus by FDA - C.

Special instructions

Use PMS-Amantadine with caution in patients with impaired renal function, while taking other antiparkinsonian drugs, as well as in the elderly. In such cases a correction of the dosage of PMS-Amantadine is needed. Patients with hyperreflexia the cancellation of treatment should be gradual.

An information about the effectiveness of PMS-Amantadine to reduce extrapyramidal disorders during treatment with antipsychotic drugs are contradictory.

During treatment avoid drinking alcohol.

In the period of treatment you should not engage in activities that require high concentration and rapid psychomotor reactions.

PMS-Amantadine drug interactions

When this drug applied simultaneously with:

- may increase the side effects of other antiparkinsonian medications.

- thiazide diuretics can not been excluded the possibility of toxic effects of PMS-Amantadine (ataxia, agitation, hallucinations), probably by reducing its renal clearance.

- quinine, quinidine may decrease the excretion of PMS-Amantadine in urine.

There was described a case of acute confusion in elderly patients while this medication was simultaneously used with co-trimoxazole.


PMS-Amantadine pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

PMS-Amantadine available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

PMS-Amantadine destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

PMS-Amantadine Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

PMS-Amantadine pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



  1. Dailymed."AMANTADINE HYDROCHLORIDE TABLET [ACTAVIS PHARMA, INC.]". (accessed August 28, 2018).
  2. "amantadine". (accessed August 28, 2018).
  3. "amantadine". (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming PMS-Amantadine?

Depending on the reaction of the PMS-Amantadine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider PMS-Amantadine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is PMS-Amantadine addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


Review conducted a study on PMS-Amantadine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of PMS-Amantadine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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What is the dose of PMS-Amantadine drug you are taking?
According to the survey conducted among website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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