DRUGS & SUPPLEMENTS

PK-Merz

Rating: 1 - 1 review(s)
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PK-Merz uses


Pharmacological action

PK-Merz is an antiparkinsonian and antiviral drug, a tricyclic symmetric adamantanamin.

This medication blocks glutamate NMDA-receptors, thus reducing the excessive stimulatory effect of cortical glutamate neurons in the neostriatum that develops against the backdrop of lack of dopamine. PK-Merz inhibits NMDA-receptors in the neurons of the substantia nigra reduces the intake of these Ca2+, which reduces the possibility of destruction of these neurons. In a greater PK-Merz influences on stiffness.

This medicine inhibits the penetration of influenza A virus into the cell.

Pharmacokinetics

PK-Merz after oral administration is completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved after 5 hours. This medication excreted in urine. T1/2 of PK-Merz sulfate is 12-13 hours, in contrast to PK-Merz hydrochloride, which T1/2 is 30 hours.

Why is PK-Merz prescribed?

Parkinson's disease, Parkinson's syndrome.

Neuralgia in Herpes Zoster, caused by the virus Varicella Zoster.

Prevention (including in combination with vaccination) and treatment of influenza A.

Dosage and administration

For oral administration the single dose is 100-200 mg.

IV in the form of infusion in 200 mg during 3 hours.

The frequency and duration of PK-Merz use depends on the evidence, the patient's response to treatment, the epidemiological situation.

The maximum dose for oral administration is 600 mg / day.

PK-Merz side effects, adverse reactions

CNS: headaches, depression, visual hallucinations, motor or mental excitement, convulsions, irritability, dizziness, sleep disturbances, tremors, mental disorders are accompanied by visual hallucinations, reduced visual acuity.

Cardiovascular system: the development or exacerbation of heart failure, orthostatic hypotension; rarely - arrhythmia, tachycardia.

Digestive system: rarely - anorexia, nausea, constipation, dry mouth.

Urinary system: patients with benign prostatic hyperplasia - difficulty urinating; polyuria, nocturia.

Dermatological reactions: dermatitis, the appearance of a bluish color of the skin of the upper and lower extremities.

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PK-Merz contraindications

Hepatic failure, chronic renal failure, psychosis (including history), hyperthyroidism, epilepsy, angle-closure glaucoma, prostatic hyperplasia, hypotension, congestive heart failure stage II-III, excited, preddeliry, delirious psychosis, I trimester of pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, increased sensitivity to PK-Merz.

Using during pregnancy and breastfeeding

The use of PK-Merz in pregnancy is possible only under strict indications and under the supervision of a physician.

If necessary to use during lactation it been should decide on the termination of breastfeeding.

Category of the fetus by FDA - C.

Special instructions

Use PK-Merz with caution in patients with impaired renal function, while taking other antiparkinsonian drugs, as well as in the elderly. In such cases a correction of the dosage of PK-Merz is needed. Patients with hyperreflexia the cancellation of treatment should be gradual.

An information about the effectiveness of PK-Merz to reduce extrapyramidal disorders during treatment with antipsychotic drugs are contradictory.

During treatment avoid drinking alcohol.

In the period of treatment you should not engage in activities that require high concentration and rapid psychomotor reactions.

PK-Merz drug interactions

When this drug applied simultaneously with:

- may increase the side effects of other antiparkinsonian medications.

- thiazide diuretics can not been excluded the possibility of toxic effects of PK-Merz (ataxia, agitation, hallucinations), probably by reducing its renal clearance.

- quinine, quinidine may decrease the excretion of PK-Merz in urine.

There was described a case of acute confusion in elderly patients while this medication was simultaneously used with co-trimoxazole.

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PK-Merz pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


PK-Merz available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


PK-Merz destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


PK-Merz Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


PK-Merz pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. "amantadine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  2. "amantadine". http://www.drugbank.ca/drugs/DB0091... (accessed August 28, 2018).
  3. "BF4C9Z1J53: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Dat... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming PK-Merz?

Depending on the reaction of the PK-Merz after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider PK-Merz not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is PK-Merz addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on PK-Merz, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of PK-Merz consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported price estimates

What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
The report given by the sDrugs.com website users shows the following figures about several people who felt the medicine PK-Merz is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
Visitors%
Expensive1
100.0%

Three visitors reported frequency of use

How often in a day do you take the medicine?
Are you taking the PK-Merz drug as prescribed by the doctor?

Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug PK-Merz is mentioned below.
Visitors%
Twice in a day1
33.3%
4 times in a day1
33.3%
Once in a day1
33.3%

Five visitors reported doses

What is the dose of PK-Merz drug you are taking?
According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
51-100mg4
80.0%
201-500mg1
20.0%

Four visitors reported time for results

What is the time duration PK-Merz drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sDrugs.com website users needed > 3 month to notice the result from using PK-Merz drug. The time needed to show improvement in health condition after using the medicine PK-Merz need not be same for all the users. It varies based on other factors.
Visitors%
> 3 month3
75.0%
1 week1
25.0%

Three visitors reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking PK-Merz drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors%
After food2
66.7%
Empty stomach1
33.3%

Five visitors reported age

Visitors%
> 605
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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