Piroxicam

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Piroxicam uses


Pharmacological action

Piroxicam is a NSAID, refers to a group oxicams. This medication has anti-inflammatory, analgesic and antipyretic effect.

The mechanism of action associated with inhibition of the enzyme COX, which leads to inhibition of prostaglandin synthesis from arachidonic acid.

Piroxicam inhibits the aggregation of platelets. For systemic use this medicine reduces the pain syndrome.

When Piroxicam used externally it weakens or suppresses inflammation and joint pain at rest and in motion, reduces morning stiffness and swelling of the joints, increases range of motion.

The analgesic effect occurs within 30 minutes after oral taking. Anti-inflammatory effect manifested by the end of the first week of treatment. After a single dose the effect lasts for 24 hours.

Pharmacokinetics

After oral administration Piroxicam is well absorbed from the gastrointestinal tract. Cmax in plasma is reached within 3-5 hours.

The proteins plasma binding is 99%. Piroxicam penetrating the placental barrier, excrets in breast milk.

Metabolized in the liver by hydrolysis and conjugation. Piroxicam is excreted unchanged and in the form of metabolites, which are displayed in the kidneys and in small amounts in feces. T1/2 is approximately 50 hours.

In patients with liver diseases T1/2 may increases.

Why is Piroxicam prescribed?

For systemic and topical use: articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), back pain, neuralgia, myalgia, traumatic inflammation of the soft tissue and musculoskeletal system.

For systemic use: dysmenorrhea in patients older than 12 years, acute infectious-inflammatory diseases of upper respiratory tract.

Dosage and administration

For oral administration the dosage is 10-30 mg 1 time / day. Rectal - 20-40 mg 1-2 times / day. In acute gout, the initial dose is 40 mg 1 time / day in the first 2 days, then 40 mg 1 time per day or 20 mg 2 times / day for 4-6 days. In acute conditions or exacerbation of a chronic process you can enter IM at a dose of 20-40 mg 1 time / day. After the relief of acute process of switching to maintenance therapy with oral forms.

Externally this medicine is applied 3-4 times / day.

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Piroxicam side effects, adverse reactions

Digestive system: common - nausea, anorexia, stomatitis, epigastric pain, diarrhea or constipation, bloating, bleeding gums ; in rare cases - erosive and ulcerative lesions of the gastrointestinal tract, with possible bleeding and perforation, transient elevation of liver enzymes, jaundice and hepatic necrosis with fatal consequences. Typically these side effects develop with chronic administration at doses exceeding 30 mg / day.

Hematopoietic system: anemia (rarely aplastic anemia or hemolytic anemia), thrombocytopenia, leukopenia, eosinophilia.

CNS and peripheral nervous system: possible dizziness, headache, drowsiness, sleep disturbances, depression, anxiety, hallucinations, mood changes, weakness, disturbances of sensitivity, swelling of the eyes, blurred vision, and signs of eye irritation.

Metabolism: rarely - hyperkalemia, hypo- or hyperglycemia, changes in body weight, in some cases - a transient increase of residual nitrogen and creatinine, uremia with hyperkalemia.

Urinary system: acute renal failure (with symptoms of hemorrhagic vasculitis), acute interstitial nephritis.

Allergic reactions: possible itching, redness, rash, pemphigus vulgaris, allergic swelling of face and hands; in some cases - Stevens-Johnson syndrome, Lyell's syndrome; in rare cases - anaphylactic reactions, bronchospasm, urticaria, angioedema, vasculitis, serum sickness.

Dermatological reactions: rarely - photosensitivity, rarely - onycholysis, alopecia.

Other: possible nosebleeds.

Local reaction: possible irritation of the rectum, tenesmus.

For external use: rarely - erythema and itching at the site of application.

Piroxicam contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in acute phase, indications in a history to bronchial asthma in connection with the use of NSAIDs, violations of porphyrin metabolism, expressed by human liver and kidney failure, pregnancy, lactation, children under the age of 14 years, proctitis (rectal use), increased sensitivity to Piroxicam.

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Using during pregnancy and breastfeeding

Piroxicam is contraindicated for use in the III trimester of pregnancy. If necessary to use this drug in the I and II trimesters of pregnancy should be related to the expected benefit to the mother and the potential risk to the fetus, due to lack of reliable clinical evidence supporting the safety of Piroxicam in this period.

Piroxicam is excreted in breast milk. If necessary to use this medication during lactation should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.

Special instructions

With caution use Piroxicam if erosive and ulcerative lesions and bleeding from the gastrointestinal tract in history, dyspeptic symptoms of chronic heart failure, hepatic dysfunction and kidney failure, asthma, coagulation disorders, and concomitant administration of oral anticoagulants, allergic reactions to acetylsalicylic acid and other NSAIDs in history.

In the course of treatment is necessary to monitor the functional state of the liver and peripheral blood picture. This medicine should not be used topically in violation of the integrity of the skin.

Must avoid contact with eyes or mucous membranes.

Not recommended for use while Piroxicam and acetylsalicylic acid and other NSAIDs.

Piroxicam drug interactions

This medication Displaces from its association with blood proteins other drugs; reduces the effectiveness of antihypertensive drugs. Compared to other NSAIDs and corticosteroids Piroxicam increases the risk of ulcerogenic action. This drug increases the risk of hyperkalemia when combined with potassium-sparing potassium-based diuretics and other drugs; increases the concentration of phenytoin and lithium in the blood. Anticoagulants increase the risk of bleeding. Aspirin reduces the concentration of Piroxicam in the blood up to 80% of the original.

Piroxicam in case of emergency / overdose

Symptoms: drowsiness, blurred vision, at very high doses - loss of consciousness, coma.

Treatment: gastric lavage, taking activated charcoal, antacids (to reduce the intake), symptomatic therapy.

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Piroxicam pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Piroxicam available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Akten 3.5% drops7.5 USD
Apo-Piroxicam 10 mg Capsule0.43 USD
Apo-Piroxicam 20 mg Capsule0.75 USD
Capsules; Oral; Piroxicam 10 mg
Capsules; Oral; Piroxicam 20 mg
Feldene 10 mg capsule2.82 USD
Feldene 20 mg capsule4.93 USD
Gel; Topical; Piroxicam 0.5%
Gel; Topical; Piroxicam 1%
Gel; Topical; Piroxicam 5%
Gen-Piroxicam 10 mg Capsule0.43 USD
Injectable; Injection; Piroxicam
Injectable; Injection; Piroxicam 20 mg / ml
Novo-Pirocam 10 mg Capsule0.43 USD
Novo-Pirocam 20 mg Capsule0.75 USD
Nu-Pirox 10 mg Capsule0.43 USD
Nu-Pirox 20 mg Capsule0.75 USD
Ointment; Topical; Piroxicam 5%
Piroxicam 10 mg capsule1.44 USD
Piroxicam 20 mg capsule2.69 USD
Piroxicam powder13.16 USD
Pms-Piroxicam 20 mg Suppository1.82 USD
Suppositories; Rectal; Piroxicam 20 mg
Suspension; Rectal; Piroxicam 20 mg
Tablets, Dispersible; Oral; Piroxicam 10 mg
Tablets, Dispersible; Oral; Piroxicam 20 mg
Tablets, Effervescent; Oral; Piroxicam 20 mg
Tablets, Film-Coated; Oral; Piroxicam 10 mg
Tablets; Oral; Piroxicam 10 mg
Tablets; Oral; Piroxicam 20 mg

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Piroxicam destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Piroxicam Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Piroxicam pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."FELDENE (PIROXICAM) CAPSULE [PFIZER LABORATORIES DIV PFIZER INC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."PIROXICAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "piroxicam". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Piroxicam?

Depending on the reaction of the Piroxicam after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Piroxicam not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Piroxicam addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Piroxicam, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Piroxicam consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

Visitor reported frequency of use

No survey data has been collected yet

Two visitors reported doses

What is the dose of Piroxicam drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
1-5mg1
50.0%
51-100mg1
50.0%

One visitor reported time for results

What is the time duration Piroxicam drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 week to notice the result from using Piroxicam drug. The time needed to show improvement in health condition after using the medicine Piroxicam need not be same for all the users. It varies based on other factors.
Visitors%
1 week1
100.0%

Visitor reported administration

No survey data has been collected yet

Visitor reported age

No survey data has been collected yet

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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