DRUGS & SUPPLEMENTS

Piracetam

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When are you taking this medicine?

Piracetam uses


Pharmacological action

Piracetam is a nootropic drugs. This medication has a positive effect on metabolism and blood circulation of the brain. It increases glucose utilization, improves the course of metabolic processes, improves microcirculation in the ischemic areas, and inhibits the aggregation of activated platelets. Piracetam has a protective effect for brain damage caused by hypoxia, intoxication, an electric shock. This drug improves the integrative activity of the brain. Piracetam does not have a sedative and stimulating effect.

Pharmacokinetics

Piracetam after oral administration is quickly and almost completely absorbed from the gastrointestinal tract. Cmax in plasma is reached after about 30 minutes, in the cerebrospinal fluid in 2-8 hours. The apparent Vd is 0.6 L / kg. Piracetam does not bind to plasma proteins.

This medication distributed in all organs and tissues, crosses the blood-brain barrier and placental barrier. Piracetam selectively accumulates in the tissues of the cerebral cortex, predominantly in the frontal, parietal and occipital lobes, the cerebellum and basal ganglia.

T1/2 from plasma is 4-5 hours, from cerebrospinal fluid is 6-8 hours. This drug excreted by the kidneys unchanged. In renal insufficiency T1/2 is increases.

Why is Piracetam prescribed?

Memory disturbances, dizziness, decreased concentration, emotional lability, dementia due to cerebrovascular events, brain injury, Alzheimer's disease, in old age; comatose state of vascular, traumatic or toxic origin; treatment withdrawal and psychoorganic syndrome in chronic alcoholism; learning disorders in children not related to inadequate training or the peculiarities of family environment (as part of combination therapy); sickle cell anemia (as part of combination therapy).

Dosage and administration

Oral for adults 30-160 mg / kg in 2-4 doses. Duration of treatment is 6-8 weeks.

If necessary, Piracetam use IM or IV at an initial dose of 10 g / day. At IV administration to patients in critical condition daily dose may reach 12 g. After clinical improvement the dose is gradually reduced and transferred to an oral administration.

For children the oral dose is 30-50 mg / kg in 2-3 doses. The treatment should be continued for at least 3 weeks.

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Piracetam side effects, adverse reactions

Digestive system: rarely - dyspeptic symptoms, abdominal pain.

CNS: rarely - nervousness, agitation, irritability, anxiety, insomnia, dizziness, headache, tremor, in some cases - weakness, drowsiness.

Other: increased sexual activity.

Piracetam contraindications

Hemorrhagic stroke, severe renal impairment, hypersensitivity to Piracetam.

Using during pregnancy and breastfeeding

Adequate and well-controlled studies safety of Piracetam during pregnancy has not been carried out. Piracetam use is possible only in cases where the intended benefits to the mother outweigh the risks to the fetus.

Piracetam apparently passes into breast milk. If necessary use during lactation should solve the issue of termination of breastfeeding.

In experimental studies in animals it was showed no adverse effects of Piracetam on the fetus.

Special instructions

Piracetam use with careful in patients with severe hemostasis disorders, surgery for large and heavy bleeding; with renal insufficiency.

It is recommended constant monitoring of indicators of kidney function.

In the case of sleep disorders is recommended to cancel an evening reception of Piracetam, attaching the dose to day reception.

Piracetam drug interactions

Simultaneous administration of Piracetam with:

  • drugs of thyroid hormone may develop central effects - tremors, restlessness, irritability, sleep disturbance, confusion;
  • CNS stimulants may increase stimulating effect;
  • neuroleptics observed increased extrapyramidal disorders. There was described a case of the interaction of Piracetam while using with an extract of thyroid gland containing triiodothyronine and tetraiodothyronine when the patient had marked anxiety, irritability and sleep disorders.

    Piracetam in case of emergency / overdose

    Symptoms: amplification of possible side effects.

    Treatment: gastric lavage, activated charcoal, symptomatic therapy, hemodialysis is possible (efficiency 50-60%); there is no specific antidote.

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    Piracetam pharmaceutical active ingredients containing related brand and generic drugs:

    infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Piracetam available forms, composition, doses:

    infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


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    Piracetam destination | category:

    infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Piracetam Anatomical Therapeutic Chemical codes:

    infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Piracetam pharmaceutical companies:

    infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. "piracetam". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    2. "Piracetam". http://www.drugbank.ca/drugs/DB0921... (accessed August 28, 2018).
    3. "ZH516LNZ10: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Dat... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Piracetam?

    Depending on the reaction of the Piracetam after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Piracetam not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Piracetam addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sDrugs.com conducted a study on Piracetam, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Piracetam consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the sDrugs.com website users shows the following figures about several people who felt the medicine Piracetam is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
    Visitors%
    Expensive1
    100.0%

    One visitor reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Piracetam drug as prescribed by the doctor?

    Few medications can be taken 3 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Piracetam is mentioned below.
    Visitors%
    3 times in a day1
    100.0%

    Three visitors reported doses

    What is the dose of Piracetam drug you are taking?
    According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    201-500mg2
    66.7%
    501mg-1g1
    33.3%

    One visitor reported administration

    The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Piracetam drug, before food or after food?
    Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
    Visitors%
    Before food1
    100.0%

    One visitor reported age

    Visitors%
    > 601
    100.0%

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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