DRUGS & SUPPLEMENTS

Phentermine

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Phentermine uses


What is Phentermine?

Phentermine is an appetite suppressant of a pharmacological group of amphetamines and phenethylamines. This medication was approved to help reduce weight in obese patients for short-term use and combination with exercise, diet and behavior changes. It usually prescribed to individuals who have health risks due to their weight. This active ingredient Phentermine is manufactured and distributed in various countries under different trade brand and generic names, for example: Adipex-P (Teva), Ionamin (Celltech), Acxion (Investigacion Farmaceutica), Fastin (GlaxoSmithKline), Duromine (iNova, Douglas Pharmaceuticals), Panbesy (Eurodrug Laboratories), Phentermine (KVK-TECH), Phentermine (Eon Labs), etc. In several countries (such as the USA, Canada, Australia) this drug is a controlled substance because it can cause addiction.

Pharmacological action

Phentermine acts on the brain neurotransmitters. Phentermine is a central stimulant and an isomer of methamphetamine. It stimulates neurons to release a particular group of neurotransmitters known as catecholamines among which are dopamine, epinephrine (also called adrenaline) and norepinephrine. The appetite suppression activity of these compounds is due to its action on the central nervous system. This mechanism of action is similar to other stimulant appetite suppressants such as diethylpropion and phendimetrazine. The neurotransmitters signal the alert response which also stops the hunger.

Why is Phentermine prescribed?

Phentermine is used to reduce body weight in obese or overweight patients. Often it prescribed in a regimen of weight reduction based on exercise, behavioral modification, and caloric restriction in the management of exogenous obesity for obese or overweight patients with the presence of other risk factors. Phentermine works by directly affecting the area of the brain that controls your appetite making you feel less hungry.

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Dosage and administration

It is recommended to use Phentermine only in the short term (usually about 12 weeks) and then other non-pharmacological strategies for weight loss and healthy dieting and exercise. However, recommendations limiting its use for short-term treatment are controversial. One reason for the restriction to 12 weeks is drug tolerance, as Phentermine loses its appetite-suppressing effects after the body adjusts. On the contrary, it has been shown that this drug did not lose its effect in a trial of 36 weeks. Due to the risk of insomnia, it is recommended taking Phentermine before breakfast or 1-2 hours later.

Phentermine side effects, adverse reactions

Generally, Phentermine is relatively well tolerated but can cause some side effects because it releases catecholamines. Among the most common effects include: tachycardia, elevated blood pressure, palpitations, nervousness, irritability and insomnia. Additionally, if Phentermine is taken for long term, it may develop euphoria and addiction. Other less common side effects include blurred vision, changes in sex drive, clumsiness, confusion, diarrhea, dizziness, dry mouth, headache, irregular heartbeat, nausea or vomiting, psychosis, skin rash or itching, stomach pain, fatigue and bad taste.

Contraindications

The following people should not use Phentermine:

  • Allergy to any ingredient of Phentermine containing pharmaceutical form (usually capsules or tablets) or other sympathomimetic (eg, pseudoephedrine).
  • Taking dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken of mono-amine oxidase inhibitors (MAOIs) (eg., phenelzine) in the last 14 days.
  • With high blood pressure or moderate hyperthyroidism, glaucoma, heart or circulatory disease, or severe narrowing of blood vessels.
  • Who are in a state of agitation or have a history of alcohol or drug abuse.

    Phentermine using during pregnancy and breastfeeding

    There is no data whether Phentermine can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Thats why rgis drugs should be given to a pregnant woman only if clearly needed.

    Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

    Safety and effectiveness of Phentermine in pediatric patients have not been established.

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    Special instructions

    You healthcare professional should be informed of the following conditions:

  • If you are pregnant or plan to become pregnant or if you are breastfeeding (lactation).
  • If you are taking prescription or nonprescription medications, herbal preparations or dietary supplements.
  • If you have allergies to medicines, foods or other substances.
  • If you have a brain disorder or spinal cord, narrowing of the arteries, high blood pressure (hypertension), diabetes or high cholesterol or lipids.

    Phentermine drug interactions

    The following drugs can interact with Phentermine Quality Pharmaceutical Laboratory:

  • Dexfenfluramine, fenfluramine, furazolidone, or inhibitors of MAO (eg., phenelzine) because the risk of serious side effects such as headaches, high blood pressure, low pulse, elevated temperature or fatal lung problems.
  • Inhibitors of serotonin reuptake (such as fluoxetine).
  • Guanadrel or guanethidine because their effectiveness may be decreased by Phentermine.

    Phentermine in case of emergency / overdose

    In case of overdose of Phentermine Quality Pharmaceutical Laboratory, call your local poison control center or local emergency services.

    Manifestations of acute overdosage with Phentermine include restlessness, hyperreflexia, tremor, confusion, assaultiveness, rapid respiration, hallucinations, panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include hypertension or hypotension, arrhythmia, and circulatory collapse. Gastrointestinal symptoms include vomiting, nausea, diarrhea and abdominal cramps. Fatal poisoning usually terminates in convulsions and coma.

    Management of acute Phentermine intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Hemodialysis or peritoneal dialysis is ineffective and not recommended in this regard.

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    Phentermine pharmaceutical active ingredients containing related brand and generic drugs:

    infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Phentermine available forms, composition, doses:

    infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

    Price
    Adipex-P 37.5 mg capsule2.2 USD
    Adipex-p 37.5 mg tablet2.15 USD
    Capsules; Oral; Phentermine Hydrochloride 15 mg
    Capsules; Oral; Phentermine Hydrochloride 18.75 mg
    Capsules; Oral; Phentermine Hydrochloride 30 mg
    Capsules; Oral; Phentermine Hydrochloride 37.5 mg
    Ionamin 15 mg capsule sa1.15 USD
    Ionamin 30 mg capsule sa2.87 USD
    Phentermine 37.5 mg tablet1.54 USD
    Phentermine 8 mg tablet0.54 USD
    Phentermine HCl 15 mg capsule1.18 USD
    Phentermine HCl 30 mg capsule1.17 USD
    Phentermine HCl 37.5 mg capsule1.0 USD
    Phentermine HCl 37.5 mg tablet1.0 USD
    Phentermine hcl powder10.71 USD
    Tablets; Oral; Phentermine Hydrochloride 30 mg
    Tablets; Oral; Phentermine Hydrochloride 37.5 mg
    Tablets; Oral; Phentermine Hydrochloride 8 mg

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    Phentermine destination | category:

    infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Phentermine Anatomical Therapeutic Chemical codes:

    infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Phentermine pharmaceutical companies:

    infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."PHENTERMINE HYDROCHLORIDE TABLET [BRYANT RANCH PREPACK]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "phentermine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "phentermine". http://www.drugbank.ca/drugs/DB0019... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Phentermine?

    Depending on the reaction of the Phentermine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Phentermine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Phentermine addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sDrugs.com conducted a study on Phentermine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Phentermine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported doses

    What is the dose of Phentermine drug you are taking?
    According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    11-50mg1
    100.0%

    One visitor reported age

    Visitors%
    46-601
    100.0%

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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