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DRUGS & SUPPLEMENTS
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When are you taking this medicine? |
Paxadorm is an hypnotic drug from benzodiazepines group. This medication has a marked sedative effect, anxiolytic, sedative, anticonvulsant and central muscle relaxant effect. The mechanism of action is associated with increased inhibitory effect of GABA in the CNS by increasing the sensitivity of the GABA-receptor mediator as a result of stimulation of benzodiazepine receptors. Paxadorm increases the depth and duration of sleep. Sleep usually occurs in 20-40 minutes after ingestion and lasts for 6-8 hours. Moderately inhibits the phase of the quick sleep.
The plasma protein binding is more than 80%. Vd is 1.9 L / kg. T1/2 is an average of 26 hours. Paxadorm is excreted mainly as metabolites.
Sleep disorders of various origins, somnambulism, premedication before surgery, encephalopathy, accompanied by epileptic seizures.
The daily dose for adults is ranged from 2.5 mg to 25 mg; the multiplicity of usind is set individually. The daily dose for children is 0.6-1 mg.
CNS and peripheral nervous system: fatigue, impaired concentration, psychomotor retardation reactions, muscle weakness; rarely - headaches, ataxia, confusion, amnesia, depression, blurred vision, in predisposed patients may be worsening of suicidal thoughts, hallucinations.
Cardiovascular system: rarely - hypotension.
Digestive system: rarely - dry mouth, nausea, diarrhea.
Respiratory system: patients with obstructive pulmonary disease possible respiratory depression.
Reproductive system: changes in libido.
Allergic reactions: seldom - a skin rash, itching.
Acute respiratory failure, drug or alcohol dependence, myasthenia gravis, temporal lobe epilepsy, angle-closure glaucoma, acute intoxication with drugs, providing a depressing effect on the central nervous system or alcohol abuse, hypersensitivity to benzodiazepines.
There was not conducted adequate and well-controlled studies safety of Paxadorm during pregnancy and lactation. Paxadorm is contraindicated especially in I and III trimester of pregnancy.
If necessary Paxadorm using during lactation breastfeeding should be discontinued.
Paxadorm should be used with caution in severe respiratory failure, obstructive pulmonary disease, ataxia, sleep apnea, marked hepatic dysfunction.
With prolonged use may develop drug dependence.
During the period of treatment avoid taking alcohol.
During the period of treatment patients should refrain from activities potentially hazardous activities that require increased attention and rapid psychomotor reactions.
Simultaneous administration of Paxadorm with:
Symptoms: CNS depression of varying severity - lethargy, weakness, severe drowsiness, deep sleep, confusion, decreased response to painful stimuli; in more severe cases - ataxia, areflexia, hypotension, respiratory depression and cardiac activity, coma.
Treatment: induction of vomiting or gastric lavage, activated charcoal technique, monitoring vital signs, symptomatic therapy, intravenous fluids, if necessary - mechanical ventilation. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital).
Depending on the reaction of the Paxadorm after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Paxadorm not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Paxadorm addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology