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Paroxetine uses

Pharmacological action

Paroxetine is an antidepressant, selective serotonin reuptake inhibitor. This medication has a bicyclic structure distinct from the structures of other known antidepressants. Paroxetine has antidepressant and anxiolytic effects when expressed enough incentive effect.

Antidepressant (thymoleptic) action is related to the ability of Paroxetine selectively block the reuptake of serotonin presynaptic membrane than is caused by increase of free content of this neurotransmitter in the synaptic cleft and enhancement of its activity in the CNS.

Effect on the m-cholinergic receptors, alpha- and beta-adrenergic receptors is only slightly which determines the extremely weak intensity of the side effects.


After oral administration Paroxetine is well absorbed from the gastrointestinal tract. Ingestion did not affect absorption. Css is set to the 7-14 day since the start of therapy. The major metabolites of Paroxetine are polar and conjugated products of oxidation and methylation. Due to the low pharmacological activity of metabolites their impact on therapeutic efficacy is unlikely.

T1/2 on average is 16-24 hours. Less than 2% excreted in the urine in unchanged form, the rest - in the form of metabolites or urine (64%), or bile.

Excretion of Paroxetine is biphasic.

With long-term continuous using of this drug pharmacokinetic parameters do not change.

Why is Paroxetine prescribed?

Endogenous, neurotic and reactive depression.

Dosage and administration

When Paroxetine administered orally an initial dose is 10-20 mg / day. If necessary, depending on the evidence, the dose was increased to 40-60 mg / day. Increasing the dose spend gradually on 10 mg with intervals of 1 week. Frequency of admission is 1 time / day. The treatment of long-term. Treatment's efficacy is assessed after 6-8 weeks.

For elderly and debilitated patients, as well as renal impairment and hepatic the initial dose is 10 mg / day, the maximum dose is 40 mg / day.


Paroxetine side effects, adverse reactions

CNS: rarely - drowsiness, tremor, fatigue, insomnia.

Digestive system: rarely (when used in doses more than 20 mg) - nausea, dry mouth, and in some cases constipation. Other: rarely (when used in doses more than 20 mg) - increased sweating, ejaculation disorders.

Paroxetine contraindications

Simultaneous treatment with MAO inhibitors, and the period up to 14 days after their withdrawal, hypersensitivity to Paroxetine.

Restrictions for using

Angle-closure glaucoma, prostate adenoma, pregnancy and breastfeeding.

Using during pregnancy and breastfeeding

Category effects on the fetus by FDA - C.

Special instructions

Stop taking of Paroxetine should be gradually reducing the dose to avoid withdrawal syndrome, which manifests itself dizziness, nausea, vomiting, insomnia, confusion, increased sweating.

There is contraindicated drinking alcohol during the treatment with Paroxetine.

Be wary of over 14 days after taking of MAO inhibitors, gradually increasing the dose. MAO inhibitors should not be administered within 2 weeks after complete withdrawal of Paroxetine.

Simultaneous administration with drugs that inhibit the metabolism of liver enzymes, Paroxetine should be used in the smallest recommended doses.

In simultaneous use with drugs that induce the metabolism of enzymes it does not required any changes in the initial doses of Paroxetine.

Be wary of using Paroxetine with lithium therapy and oral anticoagulants.

There was not found carcinogenic and mutagenic properties of Paroxetine in experimental studies.

Use Paroxetine with caution in patients whose activities are connected with the necessity of high concentration of attention and quickness of psychomotor reactions.

Paroxetine drug interactions

Simultaneous administration of Paroxetine with:

  • Paroxetine may increase the plasma concentrations of any drugs metabolized with the participation of CYP2D6 isoenzyme of cytochrome P450 (antidepressants, antipsychotics derivatives of phenothiazine antiarrhythmic drugs of class IC);
  • medications inducing or inhibiting protein metabolism, there may be changes in the metabolism and pharmacokinetic parameters of Paroxetine;
  • enhances the action of alprazolam due to the decrease of its metabolism due to inhibition of CYP3A isozymes of cytochrome P450 under the influence of Paroxetine Sorres Pharma;
  • warfarin, oral anticoagulants may increase bleeding time in unaltered prothrombin time;
  • dextromethorphan, dihydroergotamine described cases of serotonin syndrome;
  • interferon it is possible to change the antidepressant action of Paroxetine;
  • tryptophan can cause the development of serotonin syndrome which manifests itself agitation, anxiety, disorders of the gastrointestinal tract, including diarrhea;
  • perphenazine increases the side effects of the CNS by inhibiting the metabolism of perphenazine under the influence of Paroxetine;
  • increased plasma concentration of tricyclic antidepressants, the risk of serotonin syndrome.
  • cimetidine increases the concentration of Paroxetine in plasma.

    Paroxetine in case of emergency / overdose

    Symptoms: nausea, vomiting, drowsiness, sinus tachycardia, dilated pupils, etc.

    Treatment: symptomatic; to remove from the stomach not absorbed part of this drug it is necessary to induce vomiting or gastric lavage.


    Paroxetine pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

    Paroxetine available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

    Apo-Paroxetine 20 mg Tablet1.05 USD
    Apo-Paroxetine 30 mg Tablet1.12 USD
    Co Paroxetine 20 mg Tablet1.05 USD
    Co Paroxetine 30 mg Tablet1.12 USD
    Mylan-Paroxetine 20 mg Tablet1.05 USD
    Mylan-Paroxetine 30 mg Tablet1.12 USD
    Novo-Paroxetine 20 mg Tablet1.05 USD
    Novo-Paroxetine 30 mg Tablet1.12 USD
    PARoxetine HCl 12.5 mg 24 Hour tablet3.76 USD
    PARoxetine HCl 25 mg 24 Hour tablet3.93 USD
    PARoxetine HCl 37.5 mg 24 Hour tablet4.04 USD
    Paroxetine hcl 10 mg tablet2.58 USD
    Paroxetine hcl 20 mg tablet2.7 USD
    Paroxetine hcl 30 mg tablet2.78 USD
    Paroxetine hcl 40 mg tablet2.93 USD
    Paxil 10 mg tablet3.91 USD
    Paxil 10 mg/5ml Suspension0.85 USD
    Paxil 20 mg tablet2.03 USD
    Paxil 30 10 mg tablet Bottle121.87 USD
    Paxil 30 30 mg tablet Bottle131.0 USD
    Paxil 30 40 mg tablet Bottle138.39 USD
    Paxil 30 mg tablet2.16 USD
    Paxil 40 mg tablet4.44 USD
    Paxil CR 12.5 mg 24 Hour tablet4.18 USD
    Paxil CR 25 mg 24 Hour tablet4.37 USD
    Paxil CR 37.5 mg 24 Hour tablet4.5 USD
    Paxil cr 12.5 mg tablet4.02 USD
    Paxil cr 25 mg tablet4.2 USD
    Paxil cr 37.5 mg tablet4.32 USD
    Pexeva 10 mg tablet5.6 USD
    Pexeva 20 mg tablet5.84 USD
    Pexeva 30 mg tablet6.11 USD
    Pexeva 40 mg tablet6.29 USD
    Phl-Paroxetine 20 mg Tablet1.05 USD
    Phl-Paroxetine 30 mg Tablet1.12 USD
    Pms-Paroxetine 20 mg Tablet1.05 USD
    Pms-Paroxetine 30 mg Tablet1.12 USD
    Pms-Paroxetine 40 mg Tablet2.1 USD
    Ratio-Paroxetine 20 mg Tablet1.05 USD
    Ratio-Paroxetine 30 mg Tablet1.12 USD
    Sandoz Paroxetine 20 mg Tablet1.05 USD
    Sandoz Paroxetine 30 mg Tablet1.12 USD
    Suspension; Oral; Paroxetine Hydrochloride 10 mg / 5 ml
    Tablets, Extended Release; Oral; Paroxetine Hydrochloride 12.5 mg
    Tablets, Extended Release; Oral; Paroxetine Hydrochloride 25 mg
    Tablets, Extended Release; Oral; Paroxetine Hydrochloride 37.5 mg
    Tablets, Film-Coated; Oral; Paroxetine Hydrochloride 20 mg
    Tablets; Oral; Paroxetine Hydrochloride 10 mg
    Tablets; Oral; Paroxetine Hydrochloride 20 mg
    Tablets; Oral; Paroxetine Hydrochloride 30 mg
    Tablets; Oral; Paroxetine Hydrochloride 40 mg


    Paroxetine destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

    Paroxetine Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

    Paroxetine pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



    1. Dailymed."BRISDELLE (PAROXETINE) CAPSULE [NOVEN THERAPEUTICS, LLC]". (accessed August 28, 2018).
    3. Dailymed."PAROXETINE MESYLATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Paroxetine?

    Depending on the reaction of the Paroxetine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Paroxetine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Paroxetine addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


    Review conducted a study on Paroxetine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Paroxetine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

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    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the website users shows the following figures about several people who felt the medicine Paroxetine is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.

    Visitor reported frequency of use

    No survey data has been collected yet

    One visitor reported doses

    What is the dose of Paroxetine drug you are taking?
    According to the survey conducted among website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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