DRUGS & SUPPLEMENTS
Panex is an antidepressant, selective serotonin reuptake inhibitor. This medication has a bicyclic structure distinct from the structures of other known antidepressants. Panex has antidepressant and anxiolytic effects when expressed enough incentive effect.
Antidepressant (thymoleptic) action is related to the ability of Panex selectively block the reuptake of serotonin presynaptic membrane than is caused by increase of free content of this neurotransmitter in the synaptic cleft and enhancement of its activity in the CNS.
Effect on the m-cholinergic receptors, alpha- and beta-adrenergic receptors is only slightly which determines the extremely weak intensity of the side effects.
After oral administration Panex is well absorbed from the gastrointestinal tract. Ingestion did not affect absorption. Css is set to the 7-14 day since the start of therapy. The major metabolites of Panex are polar and conjugated products of oxidation and methylation. Due to the low pharmacological activity of metabolites their impact on therapeutic efficacy is unlikely.
T1/2 on average is 16-24 hours. Less than 2% excreted in the urine in unchanged form, the rest - in the form of metabolites or urine (64%), or bile.
Excretion of Panex is biphasic.
With long-term continuous using of this drug pharmacokinetic parameters do not change.
Why is Panex prescribed?
Endogenous, neurotic and reactive depression.
Dosage and administration
When Panex administered orally an initial dose is 10-20 mg / day. If necessary, depending on the evidence, the dose was increased to 40-60 mg / day. Increasing the dose spend gradually on 10 mg with intervals of 1 week. Frequency of admission is 1 time / day. The treatment of long-term. Treatment's efficacy is assessed after 6-8 weeks.
For elderly and debilitated patients, as well as renal impairment and hepatic the initial dose is 10 mg / day, the maximum dose is 40 mg / day.
Panex side effects, adverse reactions
CNS: rarely - drowsiness, tremor, fatigue, insomnia.
Digestive system: rarely (when used in doses more than 20 mg) - nausea, dry mouth, and in some cases constipation. Other: rarely (when used in doses more than 20 mg) - increased sweating, ejaculation disorders.
Simultaneous treatment with MAO inhibitors, and the period up to 14 days after their withdrawal, hypersensitivity to Panex.
Restrictions for using
Angle-closure glaucoma, prostate adenoma, pregnancy and breastfeeding.
Using during pregnancy and breastfeeding
Category effects on the fetus by FDA - C.
Stop taking of Panex should be gradually reducing the dose to avoid withdrawal syndrome, which manifests itself dizziness, nausea, vomiting, insomnia, confusion, increased sweating.
There is contraindicated drinking alcohol during the treatment with Panex.
Be wary of over 14 days after taking of MAO inhibitors, gradually increasing the dose. MAO inhibitors should not be administered within 2 weeks after complete withdrawal of Panex.
Simultaneous administration with drugs that inhibit the metabolism of liver enzymes, Panex should be used in the smallest recommended doses.
In simultaneous use with drugs that induce the metabolism of enzymes it does not required any changes in the initial doses of Panex.
Be wary of using Panex with lithium therapy and oral anticoagulants.
There was not found carcinogenic and mutagenic properties of Panex in experimental studies.
Use Panex with caution in patients whose activities are connected with the necessity of high concentration of attention and quickness of psychomotor reactions.
Panex drug interactions
Simultaneous administration of Panex with:
Panex in case of emergency / overdose
Symptoms: nausea, vomiting, drowsiness, sinus tachycardia, dilated pupils, etc.
Treatment: symptomatic; to remove from the stomach not absorbed part of this drug it is necessary to induce vomiting or gastric lavage.
Panex pharmaceutical active ingredients containing related brand and generic drugs:
Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.
Panex available forms, composition, doses:
Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.
Panex destination | category:
Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.
Panex Anatomical Therapeutic Chemical codes:
A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.
Panex pharmaceutical companies:
Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.
Frequently asked QuestionsCan i drive or operate heavy machine after consuming Panex?
Depending on the reaction of the Panex after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Panex not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Panex addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
ReviewsDrugs.com conducted a study on Panex, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Panex consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.
The information was verified by Dr. Arunabha Ray, MD Pharmacology