|
|||
|
DRUGS & SUPPLEMENTS
|
Orflaz Kit
What is the dose of the medication you are taking? |
Orflaz Kit uses
Orflaz Kit consists of Azithromycin, Fluconazole, Ornidazole.Azithromycin:
Pharmacological action
Orflaz Kit is a macrolide antibiotic of azalides group. Orflaz Kit (Azithromycin) inhibits RNA-dependent protein synthesis of sensitive microorganisms.
It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.
Pharmacokinetics
Orflaz Kit (Azithromycin) rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of Orflaz Kit (Azithromycin). Cmax in plasma is reached after 2-3 hours. This medicine rapidly distributed in tissues and biological fluids. 35% of the Orflaz Kit (Azithromycin) is metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% in the urine in unchanged form.
Why is Orflaz Kit prescribed?
Infectious-inflammatory diseases caused by microorganisms susceptible to Orflaz Kit (Azithromycin), including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non gonorrheal urethritis and / or cervicitis, Lyme disease (borreliosis).
Dosage and administration
Dosage of Orflaz Kit is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.
Orflaz Kit (Azithromycin) side effects, adverse reactions
Digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes, rarely - cholestatic jaundice.
Allergic reactions: rarely - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Dermatological reactions: rarely - photosensitization.
CNS: dizziness, headache, rarely - drowsiness, weakness.
Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.
Cardiovascular system: rarely - chest pain.
Urogenital system: vaginitis, rarely - candidiasis, nephritis, increased residual nitrogen urea.
Other: rarely - hyperglycemia, arthralgia.
Contraindications
Hypersensitivity to Orflaz Kit and other macrolide antibiotics.
Using during pregnancy and breastfeeding
Orflaz Kit (Azithromycin) crosses the placental barrier. Use in pregnancy only in cases where the intended benefits to the mother outweighs the potential risk to the fetus.
If necessary to use Orflaz Kit (Azithromycin) in the lactation period should solve the issue of termination of breastfeeding.
Special instructions
Orflaz Kit not recommended for use in patients with compromised liver function.
Orflaz Kit (Azithromycin) uses with careful with impaired renal function.
This medication should be taken at least 1 hour before or 2 hours after eating or taking of antacids.
Orflaz Kit (Azithromycin) drug interactions
Simultaneous administration of Orflaz Kit (Azithromycin) with these drugs and medications may has followed effects:
Fluconazole:
Pharmacological action
Orflaz Kit is an antifungal drug from the group of triazole derivatives. Inhibits the synthesis of ergosterol disrupting the permeability of the cell wall. This medication is active against Candida, Microsporum, Cryptococcus neoformans, Trichophyton.
Pharmacokinetics
Orflaz Kit (Fluconazole) is well absorbed after oral administration. Simultaneous ingestion does not affect absorption. The bioavailability is 90%. Orflaz Kit (Fluconazole) is widely distributed in tissues and organs of the body. Its concentration in breast milk, joint fluid, saliva, sputum, vaginal secretions and peritoneal fluid are similar to those in blood plasma. The concentration in the cerebrospinal fluid is 50-90% of the level in blood plasma, regardless of the presence of inflammation of the meninges. In the stratum corneum, epidermis, dermis and sweat fluid concentrations reach values exceeding the concentration in blood plasma. T1/2 is 30 h. Orflaz Kit (Fluconazole) is excreted by the kidneys, 80% of the administered dose in an unmodified form.
Why is Orflaz Kit prescribed?
Cryptococcosis (including cryptococcal meningitis), systemic candidiasis, candidiasis of the mucous membranes, vaginal candidiasis, prevention of fungal infections in patients with lowered immunity (including AIDS patients). Fungal infections of skin, including athlete's foot, body, groin, pityriasis versicolor, onychomycosis. Deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.
Dosage and administration
Dosing regimen of Orflaz Kit is individual. This medication is prescribed for oral and IV administration. Depending on the testimony of the daily dose is 50-400 mg, the multiplicity of application is 1 times / day. If impaired renal function the dose of Orflaz Kit (Fluconazole) should be reduced.
Orflaz Kit (Fluconazole) side effects, adverse reactions
Digestive system: nausea, abdominal pain, diarrhea, flatulence.
CNS: headache, dizziness.
Allergic reactions: skin rash, anaphylactic reactions.
Orflaz Kit contraindications
Pregnancy, children up to age 1 year, increased sensitivity to Orflaz Kit (Fluconazole) and triazole compounds.
Using during pregnancy and breastfeeding
Orflaz Kit is contraindicated during pregnancy and lactation.
If necessary using this medication during lactation it should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.
Special instructions
Orflaz Kit (Fluconazole) should be used with caution in patients with severe impaired liver or kidney diseases.
Therapy can be started before the results of seeding and other laboratory tests. However, an anti-infective therapy should be corrected accordingly when the results of these studies will be known.
Orflaz Kit drug interactions
Simultaneous administration of Orflaz Kit (Fluconazole) with:
Orflaz Kit in case of emergency / overdose
Symptoms: nausea, vomiting, diarrhea and seizures in severe cases.
Treatment: gastric lavage, forced diuresis, hemodialysis (three-hour dialysis reduces the plasma concentrations of approximately 50%), symptomatic therapy.
Orflaz Kit pharmaceutical active ingredients containing related brand and generic drugs:
Orflaz Kit available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.