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DRUGS & SUPPLEMENTS
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What are the side effects you encounter while taking this medicine? |
Olmesartan Medoxomil:
Olmy-R is an antihypertensive agent, angiotensin II receptor blocker. This medication has a high selectivity to angiotensin II receptor type 1 (AT1) which are implemented with the participation of the main effects of angiotensin II. By blocking these receptors Olmy-R (Olmesartan Medoxomil) prevents and eliminates the vasoconstrictor action of angiotensin II, causes a secondary increase in plasma renin activity due to elimination of negative feedback for renin release and a direct reduction in aldosterone secretion.
When hypertension Olmy-R (Olmesartan Medoxomil) causes dose-dependent, prolonged reduction of blood pressure.
There are no details about the development of arterial hypotension after the first dose of Olmy-R (Olmesartan Medoxomil), tachyphylaxis during prolonged treatment and withdrawal.
When taking first time Olmy-R (Olmesartan Medoxomil) provides an effective and mild reduction of blood pressure within 24 hours. Maximum antihypertensive effect is achieved after 8 weeks of the therapy, although a significant effect of blood pressure lowering marked only in 2 weeks of the treatment.
Olmy-R (Olmesartan Medoxomil) is a pro-drug. It quickly turns into a pharmacologically active metabolite of olmesartan under the influence of esterases in the intestinal mucosa and blood of portal vein during absorption from the gastrointestinal tract. In blood plasma or secretions nondecomposed Olmy-R (Olmesartan Medoxomil) or unmodified side chain medoxomil group was not been determined. Cmax of olmesartan in plasma levels reached an average of approximately 2 hours after ingestion and increases almost linearly with increasing dose to 80 mg. Simultaneous ingestion does not affect the bioavailability of olmesartan. Olmesartan binding to plasma proteins is 99.7% but the potential for clinically significant shift values of binding to proteins in the interaction of olmesartan with other drugs that have a high degree of protein binding is low (this is confirmed by the fact that there is no clinically significant interaction between warfarin and olmesartan). Olmesartan is excreted in the urine (approximately 40%) and bile (approximately 60%), T1/2 is 10-15 hours. Cumulation of olmesartan is not marked.
Essential arterial hypertension.
Olmy-R is administered orally on a daily basis. The initial dose is 10 mg / day. When inefficiency the dose increases up to the optimum 20 mg / day. If necessary the dose may be increased to the maximum 40 mg / day.
For elderly patients dosage adjustment is not required. If necessary increasing the daily dose to a maximum of 40 mg / day improvement should be under careful control of blood pressure. For patients with impaired mild or moderate renal function (creatinine clearance 20-60 ml / min) the maximum daily dose is 20 mg.
Cardio-vascular system: hypotension, angina pectoris.
Hemopoietic system: thrombocytopenia.
CNS: vertigo, dizziness, headache, asthenia syndrome (fatigue, lethargy, malaise).
Respiratory system: bronchitis, pharyngitis, rhinitis, cough.
Digestive system: diarrhea, dyspepsia, gastroenteritis, abdominal pain, nausea, vomiting, increased liver enzymes.
Dermatological reactions: itching, rash, angioedema, atopic dermatitis, facial edema, urticaria.
Musculoskeletal system: arthritis, back pain, bone pain, muscle cramps, myalgia, increased activity of CK.Urinary system: hematuria, urinary tract infection.
Metabolism: hypertriglyceridemia, hyperuricemia, hyperkalemia, increased serum creatinine and urea in serum, peripheral edema.
Other: chest pain, flu-like symptoms.
Obstruction of the biliary tract, pregnancy, lactation, childhood and adolescence under the age of 18 years.
Olmy-R is contraindicated for use during pregnancy and lactation (breastfeeding).
Due to the lack of sufficient clinical experience does not recommended the use of Olmy-R (Olmesartan Medoxomil) in patients with severe renal insufficiency (creatinine clearance < 20 mL / min), patients with impaired liver function.
Olmy-R (Olmesartan Medoxomil) used with caution in patients with stenosis of the aortic or mitral valves or obstructive hypertrophic cardiomyopathy.
In the case of previous intensive therapy with diuretics, human salt-free diet, diarrhea and / or vomiting after the first dose may been developed hypotension as a result of reducing the BCC. Thats why it is necessary to eliminate the possibility of hypovolemia before starting treatment with Olmy-R (Olmesartan Medoxomil).
Olmy-R (Olmesartan Medoxomil) should be used with caution for patients with heart failure, kidney disease, renal artery stenosis in both or only one kidney because of the risk of acute hypotension, azotemia, oliguria, acute renal failure.
When treating patients with impaired renal function it is recommended periodic monitoring of potassium and creatinine in serum.
It is not recommended of Olmy-R (Olmesartan Medoxomil) using in patients with primary hyperaldosteronism.
It should be borne in mind that excessive lowering of blood pressure in patients with coronary artery disease or atherosclerosis of cerebral vessels may lead to the development of myocardial infarction or ischemic stroke.
While taking of Olmy-R (Olmesartan Medoxomil) occasionally there may be dizziness or fatigue which should be considered in the application of patients, control of vehicles and / or engaged in other potentially hazardous activities.
Simultaneous administration of Olmy-R (Olmesartan Medoxomil) with:
Symptoms: pronounced reduction in blood pressure, tachycardia.
Treatment: when pronounced reduction of blood pressure is recommended to lay the patient on his back and lifted his legs. There is recommended a gastric lavage and / or reception of activated charcoal therapy aimed at correcting dehydration and violations of water-salt metabolism, supplementation of BCC.
Ramipril:
Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals belongs to the class of drugs classified as ACE inhibitors or Angiotensin-Converting-Enzyme inhibitor.
This product is a drug prescribed for the treatment of hypertension or high blood pressure, and for the prevention of heart failures succeeding heart attacks. Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals is also used for the prevention of heart attacks, stroke and other heart related problems.
The medication is major allergen especially to patients who have had histories of allergies. Ask for a skin test from your doctor if you are a person prone to allergies and more importantly if you are allergic to the components of Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals.
Before taking the medicine, inform your doctor if you have:
liver disease
kidney disease
And if you are on a salt restricted diet or taking salt substitutes, your doctor may lower you Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals dosage or even forbid you to take the drug.
Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals is also a grudge belonging to the pregnancy category D, which means that this medicine is a sure cause of birth defects in babies and may even cause death in the 2nd and third trimester of pregnancy.
The components of Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals are also passed through breast milk and the degree of harmful effects on the nursing infant is not known. Talk to your doctor first before deciding to take Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals if you are breast feeding.
Never take Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals when performing tasks that require mental and physical alertness such as driving or operating any kind of machinery. This medication is a powerful cause of drowsiness and dizziness.
Always maintain proper hydration when taking this medicine. Lack of fluids may cause low blood pressure and may enhance dizziness and fainting.
This medicine should be taken exactly as it is prescribed by your doctor.
Each dose must be taken with a full glass of water of about 6-8 ounces.
The intake of Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals can be with or without food.
Never stop medication without first consulting your doctor even if you begin to feel better, it still important that your termination of use of this medicine must be properly supervised by your doctor.
The dosage of Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals can only be effectively determined by your doctor.
If symptoms of overdose such as extreme drowsy and dizzy feeling, weakening, fainting and fatigue settles in, immediately seek medical help.
Do not take double doses of Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals; instead, skip the dose you missed especially if it near the time for the next dose.
Possible side effects of Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals may include:
allergic reactions
difficulty in urinating
arrhythmia
changes in heartbeat
chest pains
severe drowsiness
sore throat
fever
headache
fatigue
dry tickling cough
nausea
vomiting
diarrhea
anxiety and depression
If you experience any of these side effects and if they become bothersome and intolerable, consult your doctor.
This drug may react with drugs that contain potassium and potassium supplements such as K-Dur and Klor-Con.
Diuretics may also not work well with Olmy-R (Ramipril) Karnataka Antibiotics & Pharmaceuticals as well as water pills such as Lasix, Bumex and Lozol.
Depending on the reaction of the Olmy-R after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Olmy-R not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Olmy-R addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology