DRUGS & SUPPLEMENTS

Olmesartan

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Olmesartan uses


Pharmacological action

Olmesartan is an antihypertensive agent, angiotensin II receptor blocker. This medication has a high selectivity to angiotensin II receptor type 1 which are implemented with the participation of the main effects of angiotensin II. By blocking these receptors Olmesartan prevents and eliminates the vasoconstrictor action of angiotensin II, causes a secondary increase in plasma renin activity due to elimination of negative feedback for renin release and a direct reduction in aldosterone secretion.

When hypertension Olmesartan causes dose-dependent, prolonged reduction of blood pressure.

There are no details about the development of arterial hypotension after the first dose of Olmesartan, tachyphylaxis during prolonged treatment and withdrawal.

When taking first time Olmesartan provides an effective and mild reduction of blood pressure within 24 hours. Maximum antihypertensive effect is achieved after 8 weeks of the therapy, although a significant effect of blood pressure lowering marked only in 2 weeks of the treatment.

Pharmacokinetics

Olmesartan is a pro-drug. It quickly turns into a pharmacologically active metabolite of olmesartan under the influence of esterases in the intestinal mucosa and blood of portal vein during absorption from the gastrointestinal tract. In blood plasma or secretions nondecomposed Olmesartan or unmodified side chain medoxomil group was not been determined. Cmax of olmesartan in plasma levels reached an average of approximately 2 hours after ingestion and increases almost linearly with increasing dose to 80 mg. Simultaneous ingestion does not affect the bioavailability of olmesartan. Olmesartan binding to plasma proteins is 99.7% but the potential for clinically significant shift values of binding to proteins in the interaction of olmesartan with other drugs that have a high degree of protein binding is low (this is confirmed by the fact that there is no clinically significant interaction between warfarin and olmesartan). Olmesartan is excreted in the urine (approximately 40%) and bile (approximately 60%), T1/2 is 10-15 hours. Cumulation of olmesartan is not marked.

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Why is Olmesartan prescribed?

Essential arterial hypertension.

Dosage and administration

Olmesartan is administered orally on a daily basis. The initial dose is 10 mg / day. When inefficiency the dose increases up to the optimum 20 mg / day. If necessary the dose may be increased to the maximum 40 mg / day.

For elderly patients dosage adjustment is not required. If necessary increasing the daily dose to a maximum of 40 mg / day improvement should be under careful control of blood pressure. For patients with impaired mild or moderate renal function the maximum daily dose is 20 mg.

Olmesartan side effects, adverse reactions

Cardio-vascular system: hypotension, angina pectoris.

Hemopoietic system: thrombocytopenia.

CNS: vertigo, dizziness, headache, asthenia syndrome (fatigue, lethargy, malaise).

Respiratory system: bronchitis, pharyngitis, rhinitis, cough.

Digestive system: diarrhea, dyspepsia, gastroenteritis, abdominal pain, nausea, vomiting, increased liver enzymes.

Dermatological reactions: itching, rash, angioedema, atopic dermatitis, facial edema, urticaria.

Musculoskeletal system: arthritis, back pain, bone pain, muscle cramps, myalgia, increased activity of CK.Urinary system: hematuria, urinary tract infection.

Metabolism: hypertriglyceridemia, hyperuricemia, hyperkalemia, increased serum creatinine and urea in serum, peripheral edema.

Other: chest pain, flu-like symptoms.

Olmesartan contraindications

Obstruction of the biliary tract, pregnancy, lactation, childhood and adolescence under the age of 18 years.

Using during pregnancy and breastfeeding

Olmesartan is contraindicated for use during pregnancy and lactation.

Special instructions

Due to the lack of sufficient clinical experience does not recommended the use of Olmesartan in patients with severe renal insufficiency (creatinine clearance < 20 mL / min), patients with impaired liver function.

Olmesartan used with caution in patients with stenosis of the aortic or mitral valves or obstructive hypertrophic cardiomyopathy.

In the case of previous intensive therapy with diuretics, human salt-free diet, diarrhea and / or vomiting after the first dose may been developed hypotension as a result of reducing the BCC. Thats why it is necessary to eliminate the possibility of hypovolemia before starting treatment with Olmesartan.

Olmesartan should be used with caution for patients with heart failure, kidney disease, renal artery stenosis in both or only one kidney because of the risk of acute hypotension, azotemia, oliguria, acute renal failure.

When treating patients with impaired renal function it is recommended periodic monitoring of potassium and creatinine in serum.

It is not recommended of Olmesartan using in patients with primary hyperaldosteronism.

It should be borne in mind that excessive lowering of blood pressure in patients with coronary artery disease or atherosclerosis of cerebral vessels may lead to the development of myocardial infarction or ischemic stroke.

While taking of Olmesartan occasionally there may be dizziness or fatigue which should be considered in the application of patients, control of vehicles and / or engaged in other potentially hazardous activities.

Olmesartan drug interactions

Simultaneous administration of Olmesartan with:

  • other antihypertensive drugs may increase the hypotensive effect;
  • NSAIDs may reduce hypotensive effects and increased risk of acute renal failure;
  • after therapy with antacids there was detected of decreasing bioavailability of Olmesartan;
  • lithium medications increases the toxicity of the latter (the combination is not recommended).The risk of developing hyperkalemia is increased while the taking of Olmesartan with potassium-sparing diuretics, medications containing potassium or with other drugs that can cause increased potassium levels in blood serum, for example, with heparin (a combination not recommended).

    Olmesartan in case of emergency / overdose

    Symptoms: pronounced reduction in blood pressure, tachycardia.

    Treatment: when pronounced reduction of blood pressure is recommended to lay the patient on his back and lifted his legs. There is recommended a gastric lavage and / or reception of activated charcoal therapy aimed at correcting dehydration and violations of water-salt metabolism, supplementation of BCC.

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    Olmesartan pharmaceutical active ingredients containing related brand and generic drugs:

    infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Olmesartan available forms, composition, doses:

    infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

    Price
    Benicar 20 mg tablet2.97 USD
    Benicar 40 mg tablet3.74 USD
    Benicar 5 mg tablet12.81 USD
    Benicar hct 20-12.5 mg tablet3.94 USD
    Benicar hct 40-12.5 mg tablet4.67 USD
    Benicar hct 40-25 mg tablet4.93 USD
    Olmetec 20 mg Tablet1.04 USD
    Olmetec 40 mg Tablet1.04 USD
    Tablets; Oral; Olmesartan Medoxomil 20 mg
    Tablets; Oral; Olmesartan Medoxomil 40 mg
    Tablets; Oral; Olmesartan Medoxomil 5 mg

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    Olmesartan destination | category:

    infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Olmesartan Anatomical Therapeutic Chemical codes:

    infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Olmesartan pharmaceutical companies:

    infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."BENICAR (OLMESARTAN MEDOXOMIL) TABLET, FILM COATED [DAIICHI SANKYO, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "Olmesartan". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "Olmesartan". http://www.drugbank.ca/drugs/DB0027... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Olmesartan?

    Depending on the reaction of the Olmesartan after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Olmesartan not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Olmesartan addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sDrugs.com conducted a study on Olmesartan, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Olmesartan consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported doses

    What is the dose of Olmesartan drug you are taking?
    According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    11-50mg1
    100.0%

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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