DRUGS & SUPPLEMENTS

Olmat-H

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Olmat-H uses

Olmat-H consists of Hydrochlorothiazide, Olmesartan Medoxomil.

Hydrochlorothiazide:


Olmat-H information

Olmat-H (Hydrochlorothiazide) is an antihypertensive, diuretic drug that acts on the electrolyte reabsorption in the renal tubular mechanism increasing the excretion of chloride and sodium in equivalent amounts. The exact mechanism of its antihypertensive action is not known at this time.

Olmat-H indications

Olmat-H (Hydrochlorothiazide) is typically employed for the treatment of patients suffering from hypertension, either as monotherapy or in combination with other antihypertensive medication. It is also employed in some cases as a diuretic agent. Olmat-H (Hydrochlorothiazide) therapy may also be prescribed for the treatment of hepatic cirrhosis, edema (in patients suffering from congestive heart failure), nephrotic syndrome, drug induced edema, chronic renal failure or acute glomerulonephritis. Health care professionals may prescribe this drug in order to treat other medical conditions as well; if you would like to know more about the reasons you have been prescribed this drug, it is advised to ask your personal physician.

Olmat-H warnings

Olmat-H (Hydrochlorothiazide) may not be used in the treatment of patients who are allergic to this drug, any of its components or other sulfonamide-derived medication. Also, this drug may not be suitable for use in patients that are suffering from anuria, azotemia or impaired renal functions. Caution should be employed if the patient is suffering from hepatic disease. Other medical conditions may also influence the examining health care provider's decision of prescribing Olmat-H (Hydrochlorothiazide); it is strongly recommended to make sure that the health care professional is fully aware of your health condition and medical history before starting a treatment with this drug.

Use of Olmat-H (Hydrochlorothiazide) during pregnancy or breast-feeding is also not recommended. This medicine may affect an unborn baby and it also passes into breast milk. As such, use of this drug in pregnant women or breast-feeding mothers should not be employed.

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Olmat-H intake guidelines

You should always take Olmat-H (Hydrochlorothiazide) as you have been directed by the prescribing health care specialist. While in some cases daily administration of the drug is recommended, other patients may be prescribed an intermittent therapy. Also, the number of daily doses may vary. As such, it is best that you do not follow another patient's intake schedule. If you have difficulties understanding the intake guidelines that your prescribing health care professional has provided, you should ask for further explanations from an authorized health care specialist - such as a pharmacist, a doctor or a nurse.

Olmat-H dosage

The exact Olmat-H (Hydrochlorothiazide) dosage may vary greatly from one case to another, depending on the condition being treated, on the patient's medical history and general health condition, on his or her age as well as on a number of other factors. As such you are advised to use the exact Olmat-H (Hydrochlorothiazide) dosage that has been prescribed to you and never use the dosage prescribed to another patient or a dosage that you have been prescribed in the past. Taking a different Olmat-H (Hydrochlorothiazide) dose may cause the treatment to not have the desired effect, and if you take this drug in larger doses you may have a higher risk of developing side effects, or you may suffer from an overdose.

Olmat-H overdose

You should never exceed the Olmat-H (Hydrochlorothiazide) prescribed dosage, in order to avoid an overdose with this medication. However, if you consider that you are affected by an overdose with this drug it is advised to immediately consult your personal health care provider, the local poisons center or to go to the nearest medical facility to seek emergency medical attention. The common symptoms of an overdose with Olmat-H (Hydrochlorothiazide) are dehydration and cardiac arrhythmia. The patient may also suffer from electrolyte depletion and thus may present the relevant signs and symptoms.

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Olmat-H missed dose

In case you have missed a dose of Olmat-H (Hydrochlorothiazide), it is advised that you take the dose as soon as you remember. If the moment when you remember is too close to another intake of the medication, you should completely skip the missed Olmat-H (Hydrochlorothiazide) dose and take the next scheduled dose on time. You should never take a larger dose of the drug in order to make up for a missed dose, unless your prescribing health care provider directs you to do so.

Olmat-H side effects

In some patients Olmat-H (Hydrochlorothiazide) may cause side effects. While they are not very common, it is recommended to let your personal health care provider know if you begin experiencing any side effects. Several types of symptoms are possible: dizziness, headache, paresthesias, gastric irritation, anorexia, nausea and vomiting, diarrhea or constipation, pancreatitis, jaundice, hypotension. Metabolic side effects may include glycosuria, hyperglycemia, hyperuricemia, hypokalemia or hyponatremia. Renal failure or dysfunction may develop, as well as interstitial nephritis. Some patients reported experiencing muscle spasms, restlessness, unusual weakness and blurred vision. In some cases photosensitivity, anaphylactic reactions, respiratory distress, fever, rashes, vasculitis or toxic epidermal necrolysis have occurred.

Olmat-H drug reactions

Olmat-H (Hydrochlorothiazide) may interact with barbiturates and narcotics, as well as with alcohol. If you are also following a treatment course with antidiabetic drugs, their dosage may need to be adjusted before starting to take Olmat-H (Hydrochlorothiazide). This drug may have an additive effect with other antihypertensive medication. ACE inhibitors, ACTH, corticosteroids and skeletal muscle relaxants may also interact with this drug causing unwanted effects. This drug may not be properly absorbed if the patient is also taking Colestipol resins or Cholestyramine. NSAIDs, lithium and Pressor amines may affect or be affected by Olmat-H (Hydrochlorothiazide), and as such it is strongly recommended to let the prescribing health care provider know if you are taking these or any other drugs before starting a therapy course with this medicine. Other drug interactions that are not listed here are also possible.

Olmesartan Medoxomil:


Pharmacological action

Olmat-H is an antihypertensive agent, angiotensin II receptor blocker. This medication has a high selectivity to angiotensin II receptor type 1 (AT1) which are implemented with the participation of the main effects of angiotensin II. By blocking these receptors Olmat-H (Olmesartan Medoxomil) prevents and eliminates the vasoconstrictor action of angiotensin II, causes a secondary increase in plasma renin activity due to elimination of negative feedback for renin release and a direct reduction in aldosterone secretion.

When hypertension Olmat-H (Olmesartan Medoxomil) causes dose-dependent, prolonged reduction of blood pressure.

There are no details about the development of arterial hypotension after the first dose of Olmat-H (Olmesartan Medoxomil), tachyphylaxis during prolonged treatment and withdrawal.

When taking first time Olmat-H (Olmesartan Medoxomil) provides an effective and mild reduction of blood pressure within 24 hours. Maximum antihypertensive effect is achieved after 8 weeks of the therapy, although a significant effect of blood pressure lowering marked only in 2 weeks of the treatment.

Pharmacokinetics

Olmat-H (Olmesartan Medoxomil) is a pro-drug. It quickly turns into a pharmacologically active metabolite of olmesartan under the influence of esterases in the intestinal mucosa and blood of portal vein during absorption from the gastrointestinal tract. In blood plasma or secretions nondecomposed Olmat-H (Olmesartan Medoxomil) or unmodified side chain medoxomil group was not been determined. Cmax of olmesartan in plasma levels reached an average of approximately 2 hours after ingestion and increases almost linearly with increasing dose to 80 mg. Simultaneous ingestion does not affect the bioavailability of olmesartan. Olmesartan binding to plasma proteins is 99.7% but the potential for clinically significant shift values of binding to proteins in the interaction of olmesartan with other drugs that have a high degree of protein binding is low (this is confirmed by the fact that there is no clinically significant interaction between warfarin and olmesartan). Olmesartan is excreted in the urine (approximately 40%) and bile (approximately 60%), T1/2 is 10-15 hours. Cumulation of olmesartan is not marked.

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Why is Olmat-H prescribed?

Essential arterial hypertension.

Dosage and administration

Olmat-H is administered orally on a daily basis. The initial dose is 10 mg / day. When inefficiency the dose increases up to the optimum 20 mg / day. If necessary the dose may be increased to the maximum 40 mg / day.

For elderly patients dosage adjustment is not required. If necessary increasing the daily dose to a maximum of 40 mg / day improvement should be under careful control of blood pressure. For patients with impaired mild or moderate renal function (creatinine clearance 20-60 ml / min) the maximum daily dose is 20 mg.

Olmat-H (Olmesartan Medoxomil) side effects, adverse reactions

Cardio-vascular system: hypotension, angina pectoris.

Hemopoietic system: thrombocytopenia.

CNS: vertigo, dizziness, headache, asthenia syndrome (fatigue, lethargy, malaise).

Respiratory system: bronchitis, pharyngitis, rhinitis, cough.

Digestive system: diarrhea, dyspepsia, gastroenteritis, abdominal pain, nausea, vomiting, increased liver enzymes.

Dermatological reactions: itching, rash, angioedema, atopic dermatitis, facial edema, urticaria.

Musculoskeletal system: arthritis, back pain, bone pain, muscle cramps, myalgia, increased activity of CK.Urinary system: hematuria, urinary tract infection.

Metabolism: hypertriglyceridemia, hyperuricemia, hyperkalemia, increased serum creatinine and urea in serum, peripheral edema.

Other: chest pain, flu-like symptoms.

Olmat-H contraindications

Obstruction of the biliary tract, pregnancy, lactation, childhood and adolescence under the age of 18 years.

Using during pregnancy and breastfeeding

Olmat-H is contraindicated for use during pregnancy and lactation (breastfeeding).

Special instructions

Due to the lack of sufficient clinical experience does not recommended the use of Olmat-H (Olmesartan Medoxomil) in patients with severe renal insufficiency (creatinine clearance < 20 mL / min), patients with impaired liver function.

Olmat-H (Olmesartan Medoxomil) used with caution in patients with stenosis of the aortic or mitral valves or obstructive hypertrophic cardiomyopathy.

In the case of previous intensive therapy with diuretics, human salt-free diet, diarrhea and / or vomiting after the first dose may been developed hypotension as a result of reducing the BCC. Thats why it is necessary to eliminate the possibility of hypovolemia before starting treatment with Olmat-H (Olmesartan Medoxomil).

Olmat-H (Olmesartan Medoxomil) should be used with caution for patients with heart failure, kidney disease, renal artery stenosis in both or only one kidney because of the risk of acute hypotension, azotemia, oliguria, acute renal failure.

When treating patients with impaired renal function it is recommended periodic monitoring of potassium and creatinine in serum.

It is not recommended of Olmat-H (Olmesartan Medoxomil) using in patients with primary hyperaldosteronism.

It should be borne in mind that excessive lowering of blood pressure in patients with coronary artery disease or atherosclerosis of cerebral vessels may lead to the development of myocardial infarction or ischemic stroke.

While taking of Olmat-H (Olmesartan Medoxomil) occasionally there may be dizziness or fatigue which should be considered in the application of patients, control of vehicles and / or engaged in other potentially hazardous activities.

Olmat-H drug interactions

Simultaneous administration of Olmat-H (Olmesartan Medoxomil) with:

  • other antihypertensive drugs may increase the hypotensive effect;
  • NSAIDs may reduce hypotensive effects and increased risk of acute renal failure;
  • after therapy with antacids (magnesium aluminum hydroxide) there was detected of decreasing bioavailability of Olmat-H (Olmesartan Medoxomil);
  • lithium medications increases the toxicity of the latter (the combination is not recommended).The risk of developing hyperkalemia is increased while the taking of Olmat-H (Olmesartan Medoxomil) with potassium-sparing diuretics, medications containing potassium or with other drugs that can cause increased potassium levels in blood serum, for example, with heparin (a combination not recommended).

    Olmat-H in case of emergency / overdose

    Symptoms: pronounced reduction in blood pressure, tachycardia.

    Treatment: when pronounced reduction of blood pressure is recommended to lay the patient on his back and lifted his legs. There is recommended a gastric lavage and / or reception of activated charcoal therapy aimed at correcting dehydration and violations of water-salt metabolism, supplementation of BCC.

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    Olmat-H pharmaceutical active ingredients containing related brand and generic drugs:

    infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Olmat-H available forms, composition, doses:

    infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Olmat-H destination | category:

    infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Olmat-H Anatomical Therapeutic Chemical codes:

    infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Olmat-H pharmaceutical companies:

    infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."HYDROCHLOROTHIAZIDE TABLET [QUALITEST PHARMACEUTICALS]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."BENICAR (OLMESARTAN MEDOXOMIL) TABLET, FILM COATED [DAIICHI SANKYO, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. Dailymed."AMLODIPINE BESYLATE; HYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Olmat-H?

    Depending on the reaction of the Olmat-H after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Olmat-H not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Olmat-H addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sDrugs.com conducted a study on Olmat-H, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Olmat-H consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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