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DRUGS & SUPPLEMENTS
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Norphen
What are the side effects you encounter while taking this medicine? |
Norphen uses
Norphen consists of Acetaminophen, Orphenadrine Citrate.Acetaminophen:
Pharmacological action
Norphen is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Why is Norphen (Acetaminophen) prescribed?
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Norphen dosage and administration
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Norphen side effects, adverse reactions
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Contraindications
Chronic active alcoholism, increased sensitivity to Norphen, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Using during pregnancy and breastfeeding
Norphen (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Norphen (Acetaminophen) on the fetus in humans.
Norphen (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Norphen (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Norphen (Acetaminophen).
Special Instructions
Norphen is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Norphen (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
Norphen (Acetaminophen) Drug Interactions
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Norphen (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Norphen (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Norphen (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Norphen (Acetaminophen).
When Norphen (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Norphen (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Norphen (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Norphen (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Norphen (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Norphen (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Norphen (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Norphen (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Norphen (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Norphen (Acetaminophen) with ethinylestradiol increases absorption of Norphen (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Norphen in case of emergency / overdose
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Orphenadrine Citrate:
- Indications and usage
- Contraindications
- Warnings
- Precautions
- Pregnancy
- Pediatric use
- Adverse reactions
- Drug abuse and dependence
- Overdosage
- Dosage and administration
- How supplied
- Orphenadrine citrate er 100 mg tabs
INDICATIONS AND USAGE
Norphen (Orphenadrine Citrate) citrate extended-release tablets, USP are indicated as an adjunct to rest, physical therapy and other measures for the relief of discomfort associated with acute painful musculo skeletal conditions.
CONTRAINDICATIONS
Contraindicated in patients with glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcers, prostatic hypertrophy or obstruction of the bladder neck, cardio-spasm (megaesophagus) and myasthenia gravis.
Contraindicated in patients who have demonstrated a previous hypersensitivity to the drug.
WARNINGS
Some patients may experience transient episodes of light-headedness, dizziness or syncope. Norphen (Orphenadrine Citrate) citrate may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; ambulatory patients should therefore be cautioned accordingly.
PRECAUTIONS
Confusion, anxiety and tremors have been reported in few patients receiving propoxyphene and Norphen (Orphenadrine Citrate) concomitantly. As these symptoms may be simply due to an additive effect, reduction of dosage and/or discontinuation of one or both agents is recommended in such cases.
Norphen (Orphenadrine Citrate) citrate should be used with caution in patients with tachycardia, cardiac decompensation, coronary insufficiency, cardiac arrhythmias.
Safety of continuous long-term therapy with Norphen (Orphenadrine Citrate) citrate has not been established. Therefore, if Norphen (Orphenadrine Citrate) citrate is prescribed for prolonged use, periodic monitoring of blood, urine and liver function values is recommended.
PREGNANCY
Pregnancy Category C
Animal reproduction studies have not been conducted with Norphen (Orphenadrine Citrate) citrate. It is also not known whether Norphen (Orphenadrine Citrate) citrate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Norphen (Orphenadrine Citrate) citrate should be given to a pregnant woman only if clearly needed.
PEDIATRIC USE
Safety and effectiveness in pediatric patients have not been established.
ADVERSE REACTIONS
Adverse reactions of Norphen (Orphenadrine Citrate) citrate are mainly due to the mild anti-cholinergic action of Norphen (Orphenadrine Citrate) citrate and are usually associated with higher dosage. Dryness of the mouth is usually the first adverse effect to appear. When the daily dose is increased, possible adverse effects include tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilatation of pupils, increased ocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, hypersensitivity reactions, pruritus, hallucinations, agitation, tremor, gastric irritation and rarely urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of mental confusion. These adverse reactions can usually be eliminated by reduction in dosage. Very rare cases of aplastic anemia associated with the use of Norphen (Orphenadrine Citrate) tablets have been reported. No causal relationship has been established.
DRUG ABUSE AND DEPENDENCE
Norphen (Orphenadrine Citrate) citrate has been chronically abused for its euphoric effects.[1] The mood elevating effects may occur at therapeutic doses of Norphen (Orphenadrine Citrate).[2]
OVERDOSAGE
Norphen (Orphenadrine Citrate) citrate is toxic when overdosed and typically induces anti-cholinergic effects.[3] In a review of Norphen (Orphenadrine Citrate) toxicity, the minimum lethal dose was found to be 2 to 3 grams for adults; however, the range of toxicity is variable and unpredictable.[4] Treatment for Norphen (Orphenadrine Citrate) citrate overdose is evacuation of stomach contents (when necessary), charcoal at repeated doses, intensive monitoring and appropriate supportive treatment of any emergent anti-cholinergic effects.[5]
DOSAGE AND ADMINISTRATION
Adults-Two tablets per day; one in the morning and one in the evening.
HOW SUPPLIED
Product: 68151-1463
NDC: 68151-1463-0 1 TABLET in a PACKAGE
Norphen Citrate ER 100 mg tabs
Norphen pharmaceutical active ingredients containing related brand and generic drugs:
Norphen available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.