DRUGS & SUPPLEMENTS

Nimegen

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What is the dose of the medication you are taking?

Nimegen uses


Pharmacological action

Nimegen is a pharmaceutical agent for the treatment of acne. Contributes to the normalization of terminal cell differentiation, inhibits the hyperproliferation of the epithelium of excretory ducts of the sebaceous glands, the formation of detritus and makes it easier to evacuate. Due to this reduced production of sebum and facilitates its isolation, normal structure, decreasing the inflammatory reaction around the glands. For external and systemic application Nimegen has antiseborrhea, sebostatic, anti-inflammatory, keratitis and immunomodulatory actions, strengthens the processes of regeneration in the skin.

Pharmacokinetics

When Nimegen administered orally Nimegen is absorbed from the gastrointestinal tract, absorption may increase when taken with food. Cmax plasma levels reached after 1-4 hours after ingestion.

Oral bioavailability of Nimegen is low which may be caused by parietal metabolism in the intestinal wall and the effect of "first passage" through the liver.

Nimegen is highly bound to plasma proteins. Metabolized in the liver with the formation of the main metabolite 4-oxo-isotretinoin, also there is some isomerization of Nimegen in tretinoin.

Nimegen, tretinoin and its metabolites are enterohepatic recycling.

The end of T1/2 of tretinoin is 10-20 hours. An equivalent amount is determined in the feces, mostly unchanged, and urine in the form of metabolites.

Why is Nimegen prescribed?

For Nimegen oral administration: severe nodular-cystic acne especially with the localization on the body.

For rectal administration: severe relapsing forms of acne, rashes associated with seborrheic process.

For external use: papule-pustular acne, seborrhea, rosacea, perioral dermatitis.

Dosage and administration

For oral administration initial dose of Nimegen is 500 mcg / kg / day; the maximum daily dose used for a limited time and is 1 mg / kg; the maintenance dose is 0.1-1 mg / kg / day; duration of treatment is 16 weeks, a second course conducted at intervals of 8 days. Nimegen is taken with meals in one or more receptions.

Rectal - 0.5-1 mg / kg / day, one time at night ; course of treatment - 8-12 weeks, the intervals between courses - 1-2 months.

Ointment applied thinly to the affected areas of skin 2 times / day. Duration of treatment - 4-6 weeks.

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Nimegen side effects, adverse reactions

Dermatological reactions: dry mucous membranes, skin rashes, dermatitis, pruritus, cheilitis, erythema (especially on the face), sweating, palmar-plantar desquamation and paronychia, nail dystrophy, increased proliferation of granulation tissue in the affected area, rarely - thinning hair, vasculitis, photosensitivity.

Senses: conjunctivitis, photophobia, decreased night vision, corneal opacity, weakening of the hearing.

CNS and peripheral nervous system: headache, rarely - depression, seizures, suicide, and in rare cases - intracranial hypertension.

Digestive system: nausea, rarely - colitis, bleeding from the gastrointestinal tract, transient elevation of liver transaminases and in rare cases - hepatitis.

Hematopoietic system: anemia, neutropenia, changes in platelet count, increased erythrocyte sedimentation rate.

Metabolism: increased concentrations of TG and glucose.

Musculoskeletal system: pain in muscles and joints, rarely - hyperostosis.

Other: nasal bleeding.

Rectal and topical using: 1-2 weeks of treatment may cause new eruptions, itching, swelling and redness.

Nimegen contraindications

Pregnancy, established and planned lactation, hypersensitivity to Nimegen, the simultaneous use of tetracycline antibiotics.

For oral administration: severe liver and / or kidney damage, hypervitaminosis A, significantly elevated levels of lipids in blood plasma, neoplasms.

For rectal use - diseases of the rectum.

Using Nimegen during pregnancy and lactation

Nimegen has a pronounced teratogenic and embryotoxic action.

Nimegen is contraindicated in established and planned pregnancy.

Also Nimegen is contraindicated during lactation.

Special instructions

Rectally and topically applied with caution in liver disease, kidney disease, chronic pancreatitis, decompensation of heart function, chronic intoxication.

Rectal and external use in a pronounced exacerbation of the reaction (on 1-2-week treatment) is recommended to cancel the medication for a few days before its decline, then therapy can be resumed.

For oral administration requires regular monitoring of liver function and lipid levels in blood plasma before treatment, 1 month after initiation of therapy and then every 3 months.

In diabetes, obesity, alcoholism or lipid metabolism violations recommended more frequent monitoring of laboratory parameters. In diabetes mellitus or suspected it is necessary to strictly control glucose levels in plasma.

With prolonged use may develop symptoms of chronic hypervitaminosis A.

During treatment or within a certain time after its completion can not be donors for women of childbearing age.

During the treatment, patients should not be given UV treatment, patients should avoid direct exposure to sunlight.

In the course of treatment with Nimegen may occur intolerance of contact lenses.

Safety of children and prepubertal patients has not been established.

Should avoid the simultaneous use of Nimegen and 19-nortestosterone derivatives, particularly in patients with gynecological / endocrine diseases.

Not recommended for concurrent use of other drugs with keratolytic or exfoliative properties (including other retinoids), and progesterone in the microdose (including drugs "mini-pilly").

Nimegen drug interactions

The action of Nimegen is weakened by the simultaneous application of progesterone in the microdose.

With the simultaneous application of Nimegen and vitamin A may increase toxic effects.

With the simultaneous application of Nimegen and aminoglycoside antibiotics is at risk of developing intracranial hypertension.

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Nimegen pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Nimegen available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Nimegen destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Nimegen Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Nimegen pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."SOTRET (ISOTRETINOIN) CAPSULE, GELATIN COATED SOTRET (ISOTRETINOIN) CAPSULE, LIQUID FILLED [RANBAXY LABORATORIES INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."ISOTRETINOIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "Isotretinoin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Nimegen?

Depending on the reaction of the Nimegen after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Nimegen not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Nimegen addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Nimegen, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Nimegen consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Three visitors reported frequency of use

How often in a day do you take the medicine?
Are you taking the Nimegen drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Nimegen is mentioned below.
Visitors%
Once in a day3
100.0%

Three visitors reported doses

What is the dose of Nimegen drug you are taking?
According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 6-10mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
6-10mg2
66.7%
1-5mg1
33.3%

Two visitors reported time for results

What is the time duration Nimegen drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sDrugs.com website users needed 1 week to notice the result from using Nimegen drug. The time needed to show improvement in health condition after using the medicine Nimegen need not be same for all the users. It varies based on other factors.
Visitors%
1 week1
50.0%
> 3 month1
50.0%

One visitor reported age

Visitors%
16-291
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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