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Nervon-GM uses

Nervon-GM consists of Gabapentin, Methylcobalamin.


Pharmacological action

Nervon-GM is an antiepileptic drug. Chemical structure is similar to GABA fulfilling the function of the inhibitory neurotransmitter in the CNS. It is believed that the mechanism of action of Nervon-GM (Gabapentin) is different from other anticonvulsants acting through GABA synapses (including valproate, barbiturates, benzodiazepines, inhibitors of GABA-transaminase, inhibitors of GABA capture, GABA agonists and prodrugs of GABA). In in vitro studies showed that Nervon-GM (Gabapentin) is characterized by the presence of a new peptide binding sites in the brain tissues of rats, including the hippocampus and cerebral cortex, which may be relevant to the anticonvulsant activity of Nervon-GM (Gabapentin) and its derivatives. Nervon-GM (Gabapentin) in clinically relevant concentrations is not associated with other conventional drugs and neurotransmitter receptors in the brain.

The final mechanism of action of Nervon-GM (Gabapentin) is not defined.


Nervon-GM (Gabapentin) is absorbed from the gastrointestinal tract. After oral administration of Nervon-GM (Gabapentin) Cmax in plasma achieved within 2-3 hours. The absolute bioavailability of approximately 60%. Taking of this medication in conjunction with food (including a high-fat) does not affect the pharmacokinetics of Nervon-GM (Gabapentin).

Nervon-GM (Gabapentin) is not bound to plasma proteins and has Vd 57.7 l.

Nervon-GM (Gabapentin) is excreted only by the kidneys. Signs of biotransformation of Nervon-GM (Gabapentin) in the human body were not found.

Nervon-GM (Gabapentin) is removed from plasma by hemodialysis.

The concentrations of Nervon-GM (Gabapentin) in the plasma of children were similar to those of adults.

Why is Nervon-GM prescribed?

Treatment of neuropathic pain in adults over the age of 18 years; monotherapy of partial seizures with secondary generalization and without its fot children and adults older than 12 years; as an adjunct in the treatment of partial seizures with secondary generalization and without its for adults and children aged 3 years and older.


Dosage and administration

Dosing regimen of Nervon-GM is individual, depending on the indications and treatment regimens.

Nervon-GM (Gabapentin) side effects, adverse reactions

CNS and peripheral nervous system: amnesia, ataxia, confusion, impaired coordination, depression, dizziness, dysarthria, nervous hyperexcitability, nystagmus, drowsiness, impaired thinking, tremor, muscle cramps, amblyopia, diplopia, hyperkinesia, strengthening, weakening or absence of reflexes, paresthesia, anxiety, hostility, impaired gait.

Digestive system: change in staining of teeth, diarrhea, increased appetite, dry mouth, nausea, vomiting, flatulence, anorexia, gingivitis, abdominal pain, pancreatitis, changes in liver function tests.

Hemopoietic system: leucopenia, decrease the number of leukocytes, thrombocytopenic purpura.

Respiratory system: rhinitis, pharyngitis, cough, pneumonia.

Musculoskeletal system: myalgia, arthralgia, bone fractures.

Cardiovascular: hypertension, manifestations of vasodilation.

Urinary system: urinary tract infections, urinary incontinence.

Allergic reactions: erythema multiforme, Stevens-Johnson syndrome.

Dermatological reactions: maceration of the skin, acne, itching, rash.

Other: back pain, fatigue, peripheral edema, impotence, fatigue, malaise, swelling of the face, increase in body weight, accidental injury, asthenia, flu-like syndrome, fluctuations in blood glucose in children - a viral infection, otitis media.

Nervon-GM contraindications

Hypersensitivity to Nervon-GM (Gabapentin).

Using during pregnancy and breastfeeding

Adequate and well-controlled studies on the safety of Nervon-GM during pregnancy and lactation in humans has not been conducted. If necessary use Nervon-GM (Gabapentin) during pregnancy and lactation patients should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or infant.

Nervon-GM (Gabapentin) is excreted in breast milk. When this drug used in the lactation period, the character of the action of Nervon-GM (Gabapentin) on the infant is not defined.

Category effects on the fetus by FDA - C.

Special instructions

Abrupt discontinuation of therapy by anticonvulsant drugs in patients with partial seizures may provoke a convulsive status. If necessary to reduce the dose of Nervon-GM (Gabapentin), to cancel or replace it with an alternative means it should be phased over a minimum of 1 week.

Nervon-GM (Gabapentin) is not an effective drug for treatment of absence seizures.

For patients with impaired renal function and patients in hemodialysis it requires correction of dosing regimen. Elderly patients may require correction of the dosing regimen of Nervon-GM (Gabapentin) due to the fact that such patients may decrease renal clearance.

The efficacy and safety of neuropathic pain treatment in patients under age 18 is not defined.

During the period of treatment it is necessary to avoid taking alcohol.

Prior to determining individual response to treatment the patient should refrain from potentially dangerous activities coupled with the need to focus and improve the speed of psychomotor reactions.

Nervon-GM drug interactions

Simultaneous administration of Nervon-GM (Gabapentin) with:

  • antacids reduces the absorption of Nervon-GM (Gabapentin) from the gastrointestinal tract.
  • felbamate may increase its T1/2.
  • described a case of increasing the concentration of phenytoin in blood plasma.

    Nervon-GM in case of emergency / overdose

    There was reported an acute overdose while taking 49 g of Nervon-GM (Gabapentin). Symptoms: double vision, slurred speech, drowsiness, lethargy, diarrhea.

    Treatment: maintenance therapy, hemodialysis.

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    Nervon-GM pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

    Nervon-GM available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

    Nervon-GM destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

    Nervon-GM Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

    Nervon-GM pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



    2. Dailymed."GABAPENTIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed August 28, 2018).
    3. "methylcobalamin". (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Nervon-GM?

    Depending on the reaction of the Nervon-GM after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Nervon-GM not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Nervon-GM addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


    Review conducted a study on Nervon-GM, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Nervon-GM consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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