DRUGS & SUPPLEMENTS
When are you taking this medicine?
Neorgine is a calcium channel blocker class IV with a predominant effect on the brain vessels, a derivative of piperazine. This medication improves cerebral, coronary and peripheral circulation. Neorgine (Cinnarizine) violates the entrance of calcium ions into vascular smooth muscle cells. This drug lowers the tone of arteriolar smooth muscle, decreases the vasoconstrictor response to biogenic substances (epinephrine, norepinephrine, bradykinin). Neorgine (Cinnarizine) reduces the excitability of the vestibular apparatus. In patients with impaired peripheral circulation Neorgine (Cinnarizine) improves blood flow and potentiates postischemic hyperemia. This medicine increases the resistance of tissue to hypoxia.
After oral administration Neorgine (Cinnarizine) is absorbed from the gastrointestinal tract, Cmax in plasma is reached after 1-4 h. The plasma protein binding is 91%. This medication is metabolized. T1/2 is 3-6 hours. Neorgine (Cinnarizine) is eliminated through the intestine largely unchanged, with the urine - mainly in the form of metabolites.
Ischemic attacks (including the residual effects after a stroke). Labyrinth disorders (including for maintenance therapy for dizziness, tinnitus, nystagmus, nausea and vomiting of labyrinth origin). Motion sickness (as a prophylactic agent). Prophylaxis of migraine. Meniere's disease. Prevention and treatment of disorders of peripheral circulation - atherosclerosis, thromboangiitis obliterans, Raynaud's disease, diabetic angiopathy, acrocyanosis.
The dosage regimen is individual. Neorgine is taken orally in 25-50-75 mg 3 times / day after a meal. If necessary, the treatment can begin with half the dose and gradually increasing. To achieve the optimal therapeutic effect is used continuously for several months.
Digestive system: dyspepsia, dry mouth, rarely - cholestatic jaundice.
CNS: headache, drowsiness; in elderly patients in long-term use may be extrapyramidal symptoms, depression.
Allergic reactions: rarely - skin rash.
Other: weight gain, increased sweating, in rare cases - lupus-like syndrome, lichen planus.
Hypersensitivity to Neorgine (Cinnarizine).
During pregnancy and lactation Neorgine (Cinnarizine) usage is possible only in exceptional cases, when the expected benefit to the mother far outweighs the potential risk to the fetus or infant.
Use Neorgine (Cinnarizine) with caution in patients with hypertension.
With prolonged use is recommended to perform control examination of liver, kidney, peripheral blood picture.
At the beginning of treatment you should refrain from potentially hazardous activities that require attention and speed of psychomotor reactions.
When this drug applied simultaneously with:
- tricyclic antidepressants, hypnotics, drugs that have a sedative effect, alcohol, ethanol-containing medication increases the effects on the CNS.
- antihypertensive drugs increased hypotensive effect.
- nootropics, vasodilators - increases the action of nootropic drugs and vasodilators.
- phenylpropanolamine reduces sedation effect of Neorgine (Cinnarizine) Quality Pharmaceutical Laboratory.
Treatment: gastric lavage, taking activated charcoal, symptomatic therapy. There is no a specific antidote.
Depending on the reaction of the Neorgine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Neorgine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Neorgine addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology