DRUGS & SUPPLEMENTS

Moxigram-DX

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Moxigram-DX uses

Moxigram-DX consists of Dexamethasone, Moxifloxacin.

Dexamethasone:


Pharmacological action

Moxigram-DX is a glucocorticosteroid. This medication Inhibits the function of leukocytes and tissue macrophages. Moxigram-DX (Dexamethasone) restricts the migration of leukocytes in the area of inflammation. This drug violates the ability of macrophages to phagocytosis and the formation of interleukin-1. Moxigram-DX (Dexamethasone) decreases capillary permeability caused by histamine release. This medicine inhibits the activity of fibroblasts and collagen formation.

Moxigram-DX (Dexamethasone) inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes.

With direct application to the vessels this drug has a vasoconstrictor effect.

Moxigram-DX (Dexamethasone) has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats.

In high doses Moxigram-DX (Dexamethasone) may increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness.

With systemic use of therapeutic activity of Moxigram-DX (Dexamethasone) is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative action.

For external and local use of therapeutic activity of Moxigram-DX (Dexamethasone) is due to anti-inflammatory, antiallergic and antiexudative (due to vasoconstrictor effect) effect.

Pharmacokinetics

The plasma protein binding is 60-70%. This medication penetrates histohematic barriers. In a small amount it is excreted in breast milk. Moxigram-DX (Dexamethasone) metabolized in a liver. T1/2 is 2-3 hours. This drug is excreted by kidneys.

When Moxigram-DX (Dexamethasone) applied topically in ophthalmology it absorbed through the cornea with intact epithelium in moisture anterior chamber. When inflammation of the tissues of the eye or mucosal damage and corneal absorption rate of Moxigram-DX (Dexamethasone) significantly increased.

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Why is Moxigram-DX prescribed?

For oral administration: Biermer's disease; acute and subacute thyroiditis, hypothyroidism, progressive ophthalmopathy associated with thyrotoxicosis; bronchial asthma; rheumatoid arthritis in the acute phase; ulcerative colitis; connective tissue disease; autoimmune hemolytic anemia, thrombocytopenia, aplasia and hypoplasia of hematopoiesis, agranulocytosis, serum sickness; acute erythroderma, pemphigus (normal), acute eczema (early treatment); malignant tumor (as a palliative therapy); congenital adrenogenital syndrome; cerebral edema (usually after a preliminary parenteral corticosteroids).

For parenteral administration: shock of various origins; swelling of the brain (with brain tumors, head injury, neurosurgical intervention, brain hemorrhage, encephalitis, meningitis, radiation damage); asthmatic status; severe allergic reactions (angioedema, bronchospasm, dermatosis, acute anaphylactic reaction to medication, transfusion serum, pyrogenic reactions); acute hemolytic anemia, thrombocytopenia, acute lymphoblastic leukemia, agranulocytosis; serious infectious diseases (in combination with antibiotics); acute adrenal insufficiency, acute croup; arthropathy (scapulohumeral periarthritis, epicondylitis, styloiditis, bursitis, tenosynovitis, compression neuropathy, osteochondrosis, arthritis of various etiologies, osteoarthritis).

For use in ophthalmic practice: not purulent and allergic conjunctivitis, keratitis, keratoconjunctivitis without damaging the epithelium, iritis, iridocyclitis, blefaroconjuntivitis, blepharitis, episcleritis, scleritis, inflammation of injuries and eye surgeries, sympathetic ophthalmia.

Dosage and administration

The dosing regimen is individual. Orally for severe disease at the beginning of treatment it is prescribed to 10-15 mg / day, maintenance dose may be 2-4.5 mg / day or more. The daily dose divided into 2-3 doses. In small doses Moxigram-DX is taken 1 time in the morning.

For parenteral administration this medication is administered IV slowly bolus or infusion (acute and urgent conditions); IM; it is possible also periarticular and intraarticular injection. During the day it can be administered from 4 to 20 mg of Moxigram-DX (Dexamethasone) 3-4 times / day. The duration of parenteral administration is usually 3-4 days, then move on to maintenance therapy of oral form. In the acute period in various diseases and early treatment Moxigram-DX (Dexamethasone) used in higher doses. Upon reaching the effect the dose is decreased within a few days before reaching the maintenance dose or until discontinuation of treatment.

When used in ophthalmology for acute conditions this drug instilled into conjunctival sac 1-2 drops every 1-2 hours, then with a decrease in inflammation after every 4-6 hours. The duration of treatment is from 1-2 days to several weeks depending on the clinical course of disease.

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Moxigram-DX (Dexamethasone) side effects, adverse reactions

Endocrine system: impaired glucose tolerance, steroid diabetes mellitus or manifestation of latent diabetes mellitus, suppression of adrenal function, Itsenko-Cushing syndrome (including moon face, obesity, pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, myasthenia gravis, striae), delayed sexual development in children.

Metabolism: increased excretion of calcium, hypocalcemia, weight gain, negative nitrogen balance (increased protein breakdown), increased sweating, hypernatremia, hypokalemia.

CNS: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor cerebellum, headache, convulsions.

Cardio-vascular system: arrhythmia, bradycardia (up to cardiac arrest); development (in predisposed patients) or increased severity of chronic heart failure, ECG changes typical of hypokalemia, increased blood pressure, hypercoagulability, thrombosis. In patients with acute and subacute myocardial infarction - spread necrosis, slowing the formation of scar tissue that can lead to rupture of the heart muscle; with intracranial introduction - nosebleeds.

Digestive system: nausea, vomiting, pancreatitis, steroid gastric and duodenal ulcers, erosive esophagitis, bleeding and perforation of the gastrointestinal tract, increase or decrease in appetite, flatulence, hiccups; rarely - increased activity of hepatic transaminases and alkaline phosphatase.

Sensory organs: posterior subcapsular cataracts, increased intraocular pressure with possible damage to the optic nerve, propensity to develop secondary bacterial, fungal or viral infections of the eye, trophic changes of the cornea, exophthalmos.

Musculoskeletal system: growth retardation and ossification processes in children (premature closure of epiphyseal growth zones), osteoporosis (very rare - a pathological bone fractures, aseptic necrosis of head of humerus and femur), rupture of tendons of muscles, steroid myopathy, reduced muscle mass (atrophy).

Dermatological reactions: delayed wound healing, petechiae, ecchymosis, skin thinning, hyper or hypopigmentation, steroid acne, stretch marks, susceptibility to the development of pyoderma and candidiasis.

Allergic reactions: generalized (including skin rash, itching, anaphylactic shock) and when applied topically.

Effects associated with immunosuppressive action: development or worsening of infection (the appearance of this side effect contribute jointly used immunosuppressive drugs, and vaccinations).

Local reactions: when Moxigram-DX (Dexamethasone) administered parenteral - tissue necrosis.

For external use: rarely - itching, redness, burning, dryness, folliculitis, acne, hypopigmentation, perioral dermatitis, allergic dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria. With prolonged use or application to large areas of skin may develop systemic side effects characteristic of SCS.

Moxigram-DX contraindications

For short-term use for health reasons - increased sensitivity to Moxigram-DX (Dexamethasone).

For intra-articular injection and injection directly into the lesion: previous arthroplasty, abnormal bleeding (endogenous or caused by the use of anticoagulants), intra-articular fracture, infection (sepsis) inflammation in the joints and periarticular infections (including in history), as well as general infectious disease, pronounced juxta-articular osteoporosis, no signs of inflammation in the joints ("dry" joint, such as osteoarthritis without synovitis), severe bone destruction and deformity of the joint (a sharp narrowing of joint space, ankylosis), instability of the joint as a result of arthritis, aseptic necrosis of the epiphyses of bones forming the joint.

For external use: bacterial, viral, fungal skin diseases, tuberculosis, skin, cutaneous manifestations of syphilis, skin tumors, post-vaccination period, violation of the integrity of the skin (ulcers, wounds), children's age (up to 2 years, with itching in the anal area - up to 12 years), rosacea, acne vulgaris, perioral dermatitis.

For use in ophthalmology: bacterial, viral, fungal eye diseases, tuberculosis eye damage, tampering with the ocular epithelium, acute form of purulent eye infection in the absence of specific therapy, diseases of the cornea, combined with defects in the epithelium, trachoma, glaucoma.

Using during pregnancy and breastfeeding

During pregnancy and lactating Moxigram-DX (Dexamethasone) is used taking into account the expected therapeutic effect and adverse effect on the fetus. Long-term therapy during pregnancy does not exclude the possibility of violations of fetal growth. In the case of the end of pregnancy there is a danger of atrophy of the adrenal cortex of the fetus, which may require replacement therapy in the newborn.

Category effects on the fetus by FDA - C.

Moxigram-DX (Dexamethasone) in case of emergency / overdose

Symptoms: increased side effects.

Treatment: the development of adverse reactions - symptomatic therapy, the Itsenko-Cushing syndrome - the prescription of aminoglutethimide.

Moxifloxacin:


Moxigram-DX information

This medication, also known as Moxigram-DX (Moxifloxacin), is a drug that belongs to a wide class of medicines called fluoroquinolones. Fluoroquinolones (therefore, also Moxigram-DX (Moxifloxacin)) helps the body's immune system fight against bacteria that causes harmful effects.

Moxigram-DX indications

Moxigram-DX (Moxifloxacin) is usually prescribed in the treatment of "popular" bacterial infections like the following ones:

Pneumonia

Chronic bronchitis

Sinusitis

Moxigram-DX warnings

You should discuss with your doctor before starting a treatment with Moxigram-DX (Moxifloxacin). Inform your personal physician if you are suffering or have recently suffered from any of the following conditions:

You or a member of your family has suffered from any type of heart disorder (such as QT interval prolongation) If you have followed a treatment with heart medicines such as quinidine (Quinaglute, Cardioquin, Quinidex), procainamide (Procan SR, Pronestyl), amiodarone (Pacerone, Cordarone), sotalol (Betapace), etc.

Slow heart rate

Low level of K+ in the blood

Liver disease

Heart disease

Epilepsy or any other disorders that cause seizures

If you have been suffering from any of the conditions mentioned above you might not be allowed to take Moxigram-DX (Moxifloxacin) or your doctor might want to monitor your treatment or to make necessary dosage adjustments.

Moxigram-DX (Moxifloxacin) is a Category C FDA Pregnancy drug. Therefore, it has not been clearly established whether this drug can cause harm to an unborn child or to the carrying mother. If you are pregnant or are planning to be so soon, you should consult with your doctor before starting a treatment with this drug. Moxigram-DX (Moxifloxacin) is known to pass into breast milk. If you are breastfeeding an infant you should not start taking this medicine without consulting it with your physician.

This drug should not be prescribed in patients under 18 years old.

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Moxigram-DX intake guidelines

You should accompany each and every dose of Moxigram-DX (Moxifloxacin) that you take with a glass of water. You may take this drug either on a full or on an empty stomach. Drink plenty of water during your treatment with Moxigram-DX (Moxifloxacin) (Moxifloxacin). Do not stop your treatment with Moxigram-DX (Moxifloxacin) without your doctor's consent.

Moxigram-DX dosage

Ask your doctor to calculate the dose of Moxigram-DX (Moxifloxacin) that suits you best. The correct dosage varies from one person to another, as it depends on a couple of factors. This drug is usually taken only once a day.

Moxigram-DX overdose

If you are suffering from overdose with this drug you might have some of the following symptoms:

Poor coordination

Diarrhea

Seizures

Sleepiness

Tremors

Vomiting

If you are experiencing any of the symptoms listed here, you are in need of medical attention (inform your doctor immediately).

Moxigram-DX missed dose

Moxigram-DX (Moxifloxacin) should be taken in or on a regular basis. If you are following a treatment with Moxigram-DX (Moxifloxacin), try not to miss any of your doses. If you happen to miss one take it as soon as possible and continue with your regular schedule. You should not take in a double dose of this drug unless you are instructed by your physician to do so.

Moxigram-DX side effects

Among this drug's serious side effects are:

Allergy to the drug or some of its components (difficulty in breathing, throat closure, swelling of the tongue, lips, face, and sometimes hives)

Rapid or irregular pulse

Seizures

Fainting

Liver damage (nausea, yellowing of the eyes or skin, abdominal discomfort or pain, abnormal bruising or bleeding, fatigue)

Skin rashes

Joint or muscle pains

If you are experiencing these side effects stop your treatment and inform your physician.

Moxigram-DX (Moxifloxacin) can also induce other side effects (more common and less serious) such as:

Vomiting, nausea, diarrhea or abdominal pain

Headache

Dizziness

Increased skin sensitivity to direct sunlight

These mild side effects shouldn't stop you from continuing with your treatment. However, you should inform your doctor at once.

Other side effects may also occur when you take Moxigram-DX (Moxifloxacin). Inform your physician immediately if you experience anything unusual while taking this drug.

Moxigram-DX drug interactions

You should consult with your personal physician before you start a treatment with Moxigram-DX (Moxifloxacin). This drug can interact with drugs such as herbal products, vitamins and minerals. Among these drugs there are warfarin (Coumadin); or an anti-inflammatory non-steroidal drug (NSAID) like ibuprofen (Nuprin, Motrin, and Advil), naproxen (Naprosyn, Aleve, and Anaprox), ketoprofen (Oruvail, Orudis KT, and Orudis) and other drugs that have not been mentioned here.

Please inform you personal doctor if you are following a treatment with any of the following medicines:

Heart medicines such as quinidine (Quinaglute, Cardioquin, Quinidex), procainamide (Procan SR, Pronestyl), amiodarone (Pacerone, Cordarone), sotalol (Betapace) and any other medicine of this type

Tricyclic antidepressants such as amitriptyline (Endep, Elavil), Imipramine (Tofranil), amoxapine (Asendin), thioridazine (Mellaril), mesoridazine (Serentil), and others Erythromycin (Ery-Tab, E-Mycin, E.E.S, and any other drugs of this type)

Cisapride (Propulsid)

All the medicines stated above affect your regular pulse. You might need Moxigram-DX (Moxifloxacin) dosage adjustments or special monitoring during your treatment with Moxigram-DX (Moxifloxacin) if you are taking these drugs.

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Moxigram-DX pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Moxigram-DX available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Moxigram-DX destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Moxigram-DX Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Moxigram-DX pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."DEXAMETHASONE TABLET [PHYSICIANS TOTAL CARE, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."DEXAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "dexamethasone". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Moxigram-DX?

Depending on the reaction of the Moxigram-DX after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Moxigram-DX not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Moxigram-DX addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Moxigram-DX, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Moxigram-DX consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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