DRUGS & SUPPLEMENTS

Minoxidil

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What are the side effects you encounter while taking this medicine?

Minoxidil uses


A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)

Indication: For the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia.

Minoxidil is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. Minoxidil is also used topically to treat androgenetic alopecia. Microcirculatory blood flow in animals is enhanced or maintained in all systemic vascular beds. In man, forearm and renal vascular resistance decline; forearm blood flow increases while renal blood flow and glomerular filtration rate are preserved. The predominant site of Minoxidil action is arterial. Venodilation does not occur with Minoxidil; thus, postural hypotension is unusual with its administration. The antihypertensive activity of Minoxidil is due to its sulphate metabolite, Minoxidil sulfate.

Pharmacological action

Minoxidil is a drugs for the treatment of hair loss. This medication has a stimulating effect on hair growth in men and women with androgenetic alopecia. The appearance of signs of hair growth observed after 4 months or more of taking the drug 2 times / day. The beginning and the severity of the effect may vary in different patients. After the abolition of Minoxidil new hair growth stops, and after 3-4 months may restore the original appearance.

The exact mechanism of action of Minoxidil as a hair growth stimulant in patients with androgenic alopecia is unknown.

When used systemically this medicine has a vasodilating action. In controlled clinical studies after topical usage Minoxidil in patients with normal as well as with high blood pressure was not observed systemic side effects associated with systemic absorption of this drug.

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Pharmacokinetics

When used topically Minoxidil is poorly absorbed through normal intact skin: an average of 1.4% (0.3-4.5%) of the total applied dose enters the systemic blood circulation. For topical osage a concentration of Minoxidil in the serum is determined by its rate of absorption through the skin. After the termination of this medication usage approximately 95% of Minoxidil subjected to systemic absorption, is excreted in 4 days.

Why is Minoxidil prescribed?

Androgenic alopecia in men and women.

Dosage and administration

Minoxidil is applied to the skin of the scalp in a dose of 2 times / day (in the morning and evening).

Minoxidil side effects, adverse reactions

Dermatological reactions: often - redness, itching, peeling of the skin of the scalp; in some cases - hypertrichosis.

May be increase hair loss during the transition from the resting phase to the phase of hair growth (this is a temporary phenomenon can be observed after 2-6 weeks after initiation of therapy and gradually, over 2 weeks, stop).

Cardiovascular system: in some cases - hypotension.

Minoxidil contraindications

Children and teens under 18; redness, inflammation, infection, pain of the scalp (including the sunburn); hypersensitivity to Minoxidil.

Using during pregnancy and breastfeeding

Minoxidil is should not be used during pregnancy and lactation.

Special instructions

When the systemic side effects appear (retrosternal pain, palpitations, dizziness, decreased blood pressure, sudden weight gain, swelling of hands and / or legs), as well as redness and irritation at the site of rubbing Minoxidil should be discontinued and if necessary, prescribed the appropriate therapy.

In some patients after using Minoxidil observed changes in color and texture of hair.

Minoxidil drug interactions

With the simultaneous application of Minoxidil to the skin and drugs for external use, containing tretinoin, anthralin / dithranol may increase the absorption of Minoxidil.

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Minoxidil in case of emergency / overdose

Symptoms: excessive vasodilation, marked hypotension, chest pain, tachycardia or arrhythmia, movement (stiffness or trembling of hands, feet, head), sodium and water retention.

Treatment: symptomatic and supportive therapy - the IV introduction of saline solution; when hypotension - phenylephrine, angiotensin II, vasopressin, dopamine (do not use sympathomimetics, including norepinephrine and epinephrine).

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Minoxidil pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Minoxidil available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Aerosol, Foam; Topical; Minoxidil 5%
Injectable; Injection; Minoxidil 50 mg / ml
Loniten 10 mg Tablet1.52 USD
Loniten 2.5 mg Tablet0.39 USD
Lotion; Topical; Minoxidil 3%
Minoxidil 10 mg tablet1.32 USD
Minoxidil 2.5 mg tablet0.7 USD
Minoxidil powder2.07 USD
Rogaine 5 % foam0.27 USD
Rogaine ex-str starter kit28.32 USD
Solution; Topical; Minoxidil 2%
Solution; Topical; Minoxidil 5%
Tablets; Oral; Minoxidil 10 mg
Tablets; Oral; Minoxidil 2.5 mg
Tablets; Oral; Minoxidil 5 mg

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Minoxidil destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Minoxidil Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Minoxidil pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."QILIB HAIR REGROWTH TREATMENT FOR MEN (MINOXIDIL) SOLUTION [GALDERMA LABORATORIES, L.P.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."MINOXIDIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "minoxidil". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Minoxidil?

Depending on the reaction of the Minoxidil after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Minoxidil not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Minoxidil addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Minoxidil, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Minoxidil consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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