Metformin

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Metformin uses


Metformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin is the only oral antihyperglycemic agent that is not associated with weight gain. Metformin may induce weight loss and is the drug of choice for obese NIDDM patients. When used alone, Metformin does not cause hypoglycemia; however, it may potentiate the hypoglycemic effects of sulfonylureas and insulin. Its main side effects are dyspepsia, nausea and diarrhea. Dose titration and/or use of smaller divided doses may decrease side effects. Metformin should be avoided in those with severely compromised renal function (creatinine clearance < 30 ml/min), acute/decompensated heart failure, severe liver disease and for 48 hours after the use of iodinated contrast dyes due to the risk of lactic acidosis. Lower doses should be used in the elderly and those with decreased renal function. Metformin decreases fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Metformin may also have a positive effect on lipid levels.

Indication: For use as an adjunct to diet and exercise in adult patients (18 years and older) with NIDDM. May also be used for the management of metabolic and reproductive abnormalities associated with polycystic ovary syndrome (PCOS).

Metformin is an oral antihyperglycemic agent that improves glucose tolerance in patients with NIDDM, lowering both basal and postprandial plasma glucose. Metformin is not chemically or pharmacologically related to any other class of oral antihyperglycemic agents. Unlike sulfonylureas, Metformin does not produce hypoglycemia in either patients with NIDDM or healthy subjects and does not cause hyperinsulinemia. Metformin does not affect insulin secretion.

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Metformin pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Metformin available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Apo-Metformin 500 mg Tablet0.13 USD
Apo-Metformin 850 mg Tablet0.21 USD
Co Metformin 500 mg Tablet0.13 USD
Co Metformin 850 mg Tablet0.21 USD
Fortamet 1000 mg 24 Hour tablet6.01 USD
Fortamet 500 mg 24 Hour tablet2.55 USD
Fortamet er 1000 mg tablet6.93 USD
Fortamet er 500 mg tablet2.48 USD
Glucophage 1000 mg tablet2.33 USD
Glucophage 500 mg tablet0.3 USD
Glucophage 850 mg tablet0.38 USD
Glucophage XR 500 mg 24 Hour tablet1.17 USD
Glucophage XR 750 mg 24 Hour tablet1.8 USD
Glucophage xr 500 mg tablet1.14 USD
Glucophage xr 500 mg tablet sa1.11 USD
Glucophage xr 750 mg tablet1.71 USD
MetFORMIN HCl 500 mg 24 Hour tablet0.75 USD
MetFORMIN HCl 750 mg 24 Hour tablet1.25 USD
Metformin hcl 1000 mg tablet1.48 USD
Metformin hcl 500 mg tablet0.72 USD
Metformin hcl 850 mg tablet1.22 USD
Metformin hcl crystals2.14 USD
Mylan-Metformin 500 mg Tablet0.13 USD
Mylan-Metformin 850 mg Tablet0.21 USD
Novo-Metformin 500 mg Tablet0.13 USD
Novo-Metformin 850 mg Tablet0.21 USD
Nu-Metformin 500 mg Tablet0.13 USD
Nu-Metformin 850 mg Tablet0.21 USD
Pms-Metformin 500 mg Tablet0.13 USD
Pms-Metformin 850 mg Tablet0.21 USD
Ran-Metformin 500 mg Tablet0.13 USD
Ratio-Metformin Hydrochloride 500 mg Tablet0.13 USD
Ratio-Metformin Hydrochloride 850 mg Tablet0.21 USD
Riomet 500 mg/5 ml solution0.27 USD
Riomet 500 mg/5ml Solution0.27 USD
Sandoz Metformin Fc 500 mg Tablet0.13 USD
Sandoz Metformin Fc 850 mg Tablet0.21 USD
Tablets, Enteric Coated; Oral; Metformin Hydrochloride 500 mg
Tablets, Extended Release; Oral; Metformin Hydrochloride 1 g
Tablets, Extended Release; Oral; Metformin Hydrochloride 500 mg
Tablets, Extended Release; Oral; Metformin Hydrochloride 750 mg
Tablets, Film-Coated; Oral; Metformin Hydrochloride 1 g
Tablets, Film-Coated; Oral; Metformin Hydrochloride 1000 mg
Tablets, Film-Coated; Oral; Metformin Hydrochloride 250 mg
Tablets, Film-Coated; Oral; Metformin Hydrochloride 500 mg
Tablets, Film-Coated; Oral; Metformin Hydrochloride 850 mg
Tablets; Oral; 850 mg
Tablets; Oral; Metformin Hydrochloride 1 g
Tablets; Oral; Metformin Hydrochloride 250 mg
Tablets; Oral; Metformin Hydrochloride 500 mg
Tablets; Oral; Metformin Hydrochloride 625 mg
Tablets; Oral; Metformin Hydrochloride 750 mg
Tablets; Oral; Metformin Hydrochloride 850 mg
Zym-Metformin 500 mg Tablet0.13 USD

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Metformin destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Metformin Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Metformin pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."METFORMIN HYDROCHLORIDE (METFORMIN HYDROCHLORIDE ) TABLET, FILM COATED [BRYANT RANCH PREPACK]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "metformin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "metformin". http://www.drugbank.ca/drugs/DB0033... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Metformin?

Depending on the reaction of the Metformin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Metformin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Metformin addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Metformin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Metformin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Two visitors reported useful

How is the drug Metformin useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Useful1
50.0%
Not useful1
50.0%

One visitor reported side effects

Did you get side effects while taking the Metformin drug, or were there no side effects?
According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Metformin medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
Visitors%
No side effects1
100.0%

One visitor reported price estimates

What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Metformin is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
Visitors%
Expensive1
100.0%

Two visitors reported frequency of use

How often in a day do you take the medicine?
Are you taking the Metformin drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Metformin is mentioned below.
Visitors%
Once in a day2
100.0%

Six visitors reported doses

What is the dose of Metformin drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
11-50mg2
33.3%
201-500mg2
33.3%
1-5mg1
16.7%
501mg-1g1
16.7%

Two visitors reported time for results

What is the time duration Metformin drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed > 3 month to notice the result from using Metformin drug. The time needed to show improvement in health condition after using the medicine Metformin need not be same for all the users. It varies based on other factors.
Visitors%
> 3 month2
100.0%

One visitor reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Metformin drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors%
After food1
100.0%

Six visitors reported age

Visitors%
46-603
50.0%
16-291
16.7%
> 601
16.7%
30-451
16.7%

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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