DRUGS & SUPPLEMENTS
What are the side effects you encounter while taking this medicine?
Meridol-D is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Chronic active alcoholism, increased sensitivity to Meridol-D, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Meridol-D (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Meridol-D (Acetaminophen) on the fetus in humans.
Meridol-D (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Meridol-D (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Meridol-D (Acetaminophen).
Meridol-D is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Meridol-D (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Meridol-D (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Meridol-D (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Meridol-D (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Meridol-D (Acetaminophen).
When Meridol-D (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Meridol-D (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Meridol-D (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Meridol-D (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Meridol-D (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Meridol-D (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Meridol-D (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Meridol-D (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Meridol-D (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Meridol-D (Acetaminophen) with ethinylestradiol increases absorption of Meridol-D (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.
For oral use in horses only.
Meridol-D (Domperidone) is D2 dopamine receptor antagonist. Chemically, Meridol-D (Domperidone) is 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one.
The structural formula is:
For prevention of fescue toxicosis in periparturient mares.
Orally administer 0.5 mg/lb (1.1 mg/kg) once daily starting 10 to 15 days prior to Expected Foaling Date (EFD). Treatment may be continued for up to 5 days after foaling if mares are not producing adequate milk after foaling.
|cc||Meridol-D (Domperidone) |
This is a 25 cc multi-dose syringe. Please note that for subsequent doses, it will be necessary to adjust for previous doses. For example, if the intended dose for a horse is 5 cc, then the dial ring is set at 5 cc for the first dose, at 10 cc for the second dose, at 15 cc for the third dose, at 20 cc for the fourth dose, and at 25 cc for the fifth dose.
Horses with hypersensitivity to Meridol-D (Domperidone) should not receive Meridol-D (Domperidone) Gel.
Failure of passive transfer of immunoglobulins (IgG) may occur when using Meridol-D (Domperidone) Gel even in the absence of leakage of colostrum or milk. All foals born to mares treated with Meridol-D (Domperidone) Gel should be tested for serum IgG concentrations.
Do not use in horses intended for human consumption.
Not for use in humans. For oral use in animals only. Keep this and all drugs out of reach of children. Pregnant and lactating women should use caution when handling Meridol-D (Domperidone) Gel, as systemic exposure to Meridol-D (Domperidone) may affect reproductive hormones. Meridol-D (Domperidone) is not approved for any indication in humans in the US. The safety of Meridol-D (Domperidone) in lactating women and their nursing children has not been evaluated. Consult a physician in case of accidental human exposure.
Meridol-D (Domperidone) Gel may lead to premature birth, low birth weight foals or foal morbidity if administered > 15 days prior to the expected foaling date. Accurate breeding date(s) and an expected foaling date are needed for the safe use of Meridol-D (Domperidone) Gel.
The safety of Meridol-D (Domperidone) Gel has not been evaluated in breeding, pregnant and lactating mares other than in the last 45 days of pregnancy and the first 15 days of lactation. The safety in stallions has not been evaluated. The long term effects on foals born to mares treated with Meridol-D (Domperidone) Gel have not been evaluated.
Do not use in horses with suspected or confirmed gastrointestinal blockage, as Meridol-D (Domperidone) is a prokinetic drug (it stimulates gut motility).
Use of Meridol-D (Domperidone) Gel may cause a false positive on the milk calcium test used to predict foaling.
Meridol-D (Domperidone) is a known P-glycoprotein substrate1 and its main metabolic pathway in humans is through CYP3A4. Significant inhibition of Meridol-D (Domperidone) metabolism may occur when co-administered with drugs such as erythromycin2 and ketoconazole3. This could result in significantly greater Meridol-D (Domperidone) drug exposure (multi-fold increase) when used with these drugs.
The most common adverse reactions associated with treatment with Meridol-D (Domperidone) Gel are premature lactation (dripping of milk prior foaling) and failure of passive transfer.
In a laboratory effectiveness study with 32 periparturient mares (17 treated with Meridol-D (Domperidone) Gel and 15 treated with vehicle control) 3/17 (18%) mares treated with Meridol-D (Domperidone) Gel experienced premature lactation. In the 25 foals (16 foals of mares treated with Meridol-D (Domperidone) Gel and 9 foals of vehicle control mares) evaluated for passive transfer, failure of passive transfer occurred in 13/16 (81%) foals of mares treated with Meridol-D (Domperidone) Gel and 8/9 (89%) foals of control mares. Failure of passive transfer in foals of mares treated with Meridol-D (Domperidone) Gel was not solely due to physical loss of colostrum through premature lactation, because 77% of Meridol-D (Domperidone) Gel treated mares that did not drip milk prior to foaling had foals with failure of passive transfer.
In a field study with 279 periparturient mares treated with Meridol-D (Domperidone) Gel, premature lactation was reported in 3 mares (1%) and failure of passive transfer was reported in 3 foals (1%).
In two additional field studies, a total of 2,556 mares were treated with Meridol-D (Domperidone) Gel or a bioequivalent formulation for 2,730 breeding seasons. Horses in these studies were treated with Meridol-D (Domperidone) Gel for varying durations. Of the 2,730 breeding seasons evaluated, premature lactation was reported in 262 mares (9.6%), failure of passive transfer was reported in 50 foals (1.8%), and premature parturition (gestation length ≤ 320 days) occurred in 13 mares (<0.5%).
Owners should be aware that treatment with Meridol-D (Domperidone) Gel may result in failure of passive transfer of immunoglobulins to the foal and that this may occur even when the mare does not drip milk. Owners should be advised that all foals born to mares treated with Meridol-D (Domperidone) Gel should be tested for serum immunoglobulin (IgG) concentrations. Owners should be informed that Meridol-D (Domperidone) Gel causes false positives on the milk calcium test used to predict foaling. Owners should be directed on the proper use of the multi-dose dosing syringe, including how to set the dial ring for accurate dosing after the first dose.
Meridol-D (Domperidone) is a D2 dopamine receptor antagonist that blocks the agonistic action of fescue alkaloids at the cellular level. Unlike other D2 antagonist drugs, Meridol-D (Domperidone) does not readily cross the blood-brain barrier4. Distribution studies with radio-labeled drug in animals have shown wide tissue distribution, but low brain concentration. Small amounts of the drug cross the placenta in rats5. In humans, Meridol-D (Domperidone) is 91-93% bound to plasma proteins. Meridol-D (Domperidone) in humans undergoes rapid and extensive hepatic metabolism by hydroxylation and N-dealkylation1. Urinary and fecal excretions of Meridol-D (Domperidone) in humans amount 31 and 66% of the oral dose, respectively. The proportion of the drug excreted unchanged in humans is small (10% of fecal excretion and approximately 1% of urinary excretion). The average terminal plasma half-life of Meridol-D (Domperidone) administered orally to horses is approximately 6 hours with very low systemic bioavailability.
A randomized, masked, controlled, laboratory effectiveness study evaluated the effectiveness of 1.1 mg/kg Meridol-D (Domperidone) Gel administered once daily beginning 10 to 15 days prior to the expected foaling date (EFD - defined as 340 days after the median breeding) and continuing up to 5 days after foaling for the prevention of fescue toxicosis. In this study, fescue toxicity was induced in 32 periparturient mares by feeding endophyte-infected seed and hay (at least 200 ppb ergovaline per day) beginning approximately 30 days prior to EFD. A total of 17 mares were treated with Meridol-D (Domperidone) Gel and 15 mares were treated with a vehicle control. Twenty-seven mares (13 Meridol-D (Domperidone) Gel and 14 vehicle control) were included in the statistical analysis. Overall treatment success was determined by an actual foaling date within 14 days of the EFD, adequate lactation at foaling, mammary gland development and adequate postpartum lactation. Meridol-D (Domperidone) Gel was superior to the vehicle control.
|Treatment Group |
|Pearson X2 Test|
|Vehicle Control (14)||7% (1 / 14)||Test statistic = 16.320|
|Meridol-D (Domperidone) Gel (13)||92% (12 / 13)||p-value < 0.0000|
|Treatment Group |
|Mean gestation length in days||Percent adequate milk production at foaling||Percent adequate mammary gland development at foaling|
|Vehicle Control (14)||346||33% (3 / 9) ||30% (3 / 10) |
|Meridol-D (Domperidone) Gel (13)||337||100% (13 / 13)||100% (13 / 13)|
|Test Statistic||t statistic = 3.754 |
p = 0.0014
|Pearson X2 = 8.793 |
p = 0.0030
|Pearson X2 = 9.984 |
p = 0.0016
One mare treated with Meridol-D (Domperidone) Gel was carrying twins. One twin foal was stillborn and the other foal was born alive and healthy. Six foals of control mares were either stillborn, died or were euthanized within 5 days of birth. Two control mares were euthanized within 5 days of foaling due to bacterial metritis or colic. Dystocia occurred in 1 mare treated with Meridol-D (Domperidone) Gel and 4 control mares. One mare treated with Meridol-D (Domperidone) Gel and three control mares experienced retained placentas.
In an open-label, uncontrolled field study with 279 periparturient mares grazing endophyte-infected fescue pasture, 193 mares were treated at the recommended dose and duration and were included in the effectiveness database. Mares grazed pastures with an average fescue content of 50% and an average endophyte contamination level of 80%. The mares had an average gestation length of 340 days. Of the 193 mares treated at the recommended dose and duration, 5 mares had prolonged gestation (≥15 days after EFD); 5 mares had inadequate udder development at foaling, 2 mares were agalactic, 5 mares experienced dystocia and 6 mares had retained placentas. Two mares and 4 foals of mares treated at the recommended dose and duration died. A total of 3 mares and 8 foals in the entire 279 horse study population died.
In a target animal safety study Meridol-D (Domperidone) Gel was administered orally to 32 healthy periparturient mares once daily at 0X, 1X, 3X or 5X the maximum exposure dose estimated for a 550 lb mare. Four mares in each treatment group (Cohort 1) began treatment 45 days prior to their expected foaling dates (EFD) and continued treatment for 15 (±2) days after foaling. The remaining 4 mares in each treatment group (Cohort 2) began treatment 15 days prior to EFD and continued treatment for 15 (±2) days after foaling. Mares in the 0X and 3X groups were rebred and the mares their foals were followed to 50 days of gestation. EFD was calculated as 340 days after the median breeding date.
|Number of mares started on treatment:|
|Treatment group||Dose||45 days before EFD |
|15 days before EFD |
|1|| (0X) 0.0 mg/kg ||4||4|
|2||(1X) 1.46 mg/kg||4||4|
|3||(3X) 4.38 mg/kg||4||4|
|4||(5X) 7.30 mg/kg||4||4|
Mares treated with Meridol-D (Domperidone) Gel had a higher incidence of premature parturition. There was a significant decrease in gestation length, with corresponding lower birth weights of foals, in mares treated with Meridol-D (Domperidone) Gel beginning 45 days prior to EFD (Cohort 1). Mares treated with Meridol-D (Domperidone) Gel beginning 45 days prior to EFD foaled and average of 27 days early (range 12 to 40 days early.) Mares treated with Meridol-D (Domperidone) Gel begininning 15 days prior to EFD foaled an average of 5 days early (range 12 days early to 5 days late). (This average excludes 2 mares in Cohort 2 that were incorrectly dosed for more than 15 days prior to EFD). Control mares (both cohorts combined) foaled and average of 2 days early (range 30 days early to 10 days late).
Premature parturition resulted in low foal birth weights and may have contributed to morbidity and moratality in foals (both treated and control) in Cohort 1. Four out of 12 foals born to mares treated with Meridol-D (Domperidone) Gel on Cohort 1 died or were euthanized within 11 days of birth. These foals were born 12 to 40 days early. One control foal in Cohort 2 (born 30 days early) died at 14 days. Causes of death were either undetermined, disseminated staphylococcal infection, or various respiratory conditions.
Mares treated with Meridol-D (Domperidone) Gel had a higher incidence of dripping milk (96%) prior to parturition than control mares (50%). More mares treated with Meridol-D (Domperidone) Gel (71%) dripped milk 3 or more days prior to parurition than control mares (0%). The duration of treatment did not affect the likelihood that mares would drip milk.
Failure of passive transfer occured in all groups; however, there was a greater incidence of IgG concentrations <400 mg/dL in foals of mares treated with Meridol-D (Domperidone) Gel. The incidence of failure of passive transfer also increased with dose. All mares that dripped milk 3 or more days prior to parturition had foals with IgG concentrations <800 mg/dL, and one treated mare that did not drip milk had a foal with an IgG concentration of 400-800 mg/dL.
|# Foals (percentage)||Overall incidence |
of <800 mg/dL
|Treatment Group||#Foals||<400 mg/dL||400-800 mg/dL||≥800 mg/dL|
|0X||8||3 (38%)||2 (25%)||3 (38%)||63%|
|1X|| 6 ||3 (50%)||1 (17%)||2 (33%)||67%|
|3X|| 7 ||5 (71%)||1 (14%)||1 (14%)||86%|
|5X||8||7 (88%)||1 (13%)||0 (0%)||100%|
Foals of mares treated with Meridol-D (Domperidone) Gel experienced more diarrhea and loose stool than foals of control mares during the treatment phase (first 15 days of life). All episodes of diarrhea were self-limiting and resolved without treatment.
|Treatment group |
|# Foals |
Mares treated with Meridol-D (Domperidone) Gel generally had higher white blood cell counts (WBC) and/or granulocyte counts and gamma glutamyl transferase (GGT) and/or alkaline phosphatase (ALP) concentrations than control mares. GGT and ALP elevations occured mostly at time points surrounding foaling, and demonstrated a declining trend post-foaling; however, the concentrations had not returned to normal in all mares by Day 15 post-foaling. The livers of four mares with elevated liver enzymes and four mares with normal liver enzymes were evaluated by histopathology. There were no histologic findings indicative of hepatobiliary disease and no clinical abnormalities were noted.
More foals of mares treated with Meridol-D (Domperidone) Gel had granulocyte and/or neutrophil counts below the reference range on the day of foaling than foals born to control mares. The decreased neutrophil counts in foals of mares treated with Meridol-D (Domperidone) Gel occcured more commonly in foals born more than 25 days prior to EFD. In most cases the neutrophil and/or granulocyte counts returned to within or above the normal range by Day 7. Foals of mares treated with Meridol-D (Domperidone) Gel had higher ALP concentrations than foals of control mares. Additionally, several foals of mares treated with Meridol-D (Domperidone) Gel also had elevations in GGT.
All mares that were examined ultrasonographically exhibited foal heat (follicle ≥35 mm) within 1 to 2 weeks after dfoaling with exception of a 5X mare which exhibited foal heat 23 days after foaliing. Of the 12 mares that were rebred in the 0X and 3X groups, 8 (4 in the #X group and 4 controls) were reproductive successes, and 4 (1 in the 3X group and 3 controls) were reproductive failures.
|Treatment group||# Mares bred||Pregnant at Day 50 (percentage)|
Store at controlled room temperature 25°C (77°F) with excursions between 15°-30°C (59°-86°F) permitted. Recap after each use.
Meridol-D (Domperidone) Gel is supplied in disposable, multi-dose, 25 cc syringes, each containing 2.75 g of Meridol-D (Domperidone) suspended in an oral gel. Each cc of gel contains 110 mg of Meridol-D (Domperidone). The net weight of each syringe is approximately 26 g. Syringes are supplied in single carton and six per carton.
|Meridol-D (Domperidone) Gel 1 Syringe Carton||NDC 17033-326-01|
|Meridol-D (Domperidone) Gel 6 Syringe Carton||NDC 17033-326-06|
NADA 141-314, Approved by FDA.
|OBSERVE LABEL |
Dechra Veterinary Products, 7015 College Boulevard, Suite 525, Overland Park, KS 66211
For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Dechra Veterinary Products at (866) 933-2472.
US Patents 5,372,818; 6,534,536; 6,224,895
© 2010 Dechra Ltd
Meridol-D (Domperidone) Gel is a registered trademark of Dechra Ltd. All rights reserved.
Meridol-D Karnataka Antibiotics & Pharmaceuticals is an opioid analgesic, a derivative of cyclohexanol. It is non-selective agonist of mu-, delta- and kappa-receptors in the CNS. Meridol-D (Tramadol) is a racemate (+) and (-) of isomers (50% / 50%) which in various ways are involved in analgesic effects. The isomer (+) is a pure agonist opioid receptors, it has low tropism and has a pronounced selectivity for different subtypes of receptors. The isomer (-) inhibiting neuronal capture of noradrenaline activates the descending noradrenergic influence. Thats why it is broken transmission of pain impulses in the gelatinous substance of spinal cord.
Meridol-D (Tramadol) Karnataka Antibiotics & Pharmaceuticals causes sedation. At therapeutic doses this medication almost not get respiratory depression. Meridol-D (Tramadol) has also an antitussive effect.
After oral administration Meridol-D (Tramadol) Karnataka Antibiotics & Pharmaceuticals quickly and almost completely absorbed from the gastrointestinal tract (90%). Cmax in plasma obtained in 2 h after taking this medication. Bioavailability in single dose is 68% and increases with repeated use.
Plasma protein binding is 20%. Meridol-D (Tramadol) is widely distributed in tissues. Vd after oral administration and intravenous injection is 306 l and 203 l respectively. This drug crosses the placental barrier in a concentration equal to the concentration of the active substance in the plasma. 0.1% is excreted in breast milk.
Meridol-D (Tramadol) metabolised by demethylation and conjugation to 11 metabolites, of which only 1 is active.
This medicine excreted by the kidneys - 90% and through the intestines - 10%.
Moderate and severe pain of various origins (including malignant tumors, acute myocardial infarction, disease, trauma). Conducting painful diagnostic or therapeutic procedures.
A single oral dose for adults and children over 14 years is 50 mg, rectally - 100 mg, IV slowly or IM - 50-100 mg. If for parenteral injection efficiency is not enough, it is possible oral taking in a dose of 50 mg after 20-30 minutes.
For children aged 1 to 14 years set the dose rate of 1-2 mg / kg.
The duration of treatment is determined individually.
The maximum dose for adults and children over 14 years regardless of method of administration is 400 mg / day.
CNS: dizziness, weakness, drowsiness, confusion, and in some cases - seizures and convulsions of cerebral origin (for IV uses in high doses or with concomitant administration of neuroleptics).
Cardio-vascular system: tachycardia, orthostatic hypotension, collapse.
Digestive system: dry mouth, nausea, vomiting.
Metabolism: increased sweating.
Musculoskeletal system: miosis.
During pregnancy patients should avoid prolonged use of Meridol-D Karnataka Antibiotics & Pharmaceuticals because the risk of addiction in the fetus and the occurrence of withdrawal in the neonatal period.
If necessary using in lactation (breastfeeding) should be aware that Meridol-D (Tramadol) in small amounts excreted in breast milk. In the case of long-term treatment can not been excluded the possibility of drug dependence.
Meridol-D (Tramadol) Karnataka Antibiotics & Pharmaceuticals is not recommended for treatment of withdrawal syndrome drugs.
Patients need to avoid combination with MAO inhibitors.
During the period of treatment with Meridol-D (Tramadol) Karnataka Antibiotics & Pharmaceuticals you should avoid to take alcohol.
Meridol-D (Tramadol) in the form of long-acting formulations should not be used in children under the age of 14 years.
During the period of Meridol-D (Tramadol) using is not recommended to engage in activities that require special attention, speed of psychomotor reactions.
With caution Meridol-D (Tramadol) Karnataka Antibiotics & Pharmaceuticals should be used in convulsions of central genesis of drug dependence, confusion, patients with impaired renal function and liver, as well as increased sensitivity to other opioid receptor agonists.
Meridol-D (Tramadol) should not be used beyond the period justified from a therapeutic point of view.
Simultaneous administration of Meridol-D (Tramadol) Karnataka Antibiotics & Pharmaceuticals with:
Symptoms: respiratory depression, until apnea, seizures, Pupillary, anuria, coma.
Treatment: IV injection of naloxone (a specific antagonist), gastric lavage, maintenance of vital functions.
Depending on the reaction of the Meridol-D after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Meridol-D not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Meridol-D addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology