DRUGS & SUPPLEMENTS

Mebendazole

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What are the side effects you encounter while taking this medicine?

Mebendazole uses


Pharmacological action

Mebendazole is a worming medication a broad spectrum of action, it is most effective when enterobioze. This drug causes irreversible disturbance of glucose utilization in the body of the worm and inhibits the synthesis of ATP.

Pharmacokinetics

Mebendazole is practically not absorbed from the gastrointestinal tract. The plasma protein binding is 90%. This medication is distributed unevenly in organs and accumulates in adipose tissue, liver, and larvae of helminths. Mebendazole is metabolized in the liver to 2-amino derivative.

T1/2 is 2.5-5.5 hours. More than 90% of the dose is excreted unchanged in feces. Grown deep portion is excreted by kidneys.

Why is Mebendazole prescribed?

Enterobiasis, ascariasis, hookworm disease, strongyloidiasis, trichuriasis, trichinosis, teniasis, echinococcosis, mixed helminth infections.

Dosage and administration

For adults and children over 10 years at enterobioze a single dose is 100 mg.

For children aged 2 to 10 years a single dose is 25-50 mg. In the case of a high probability of re-infestation the drug taking repeats after 2-4 weeks in the same dose.

It is recommended that simultaneous treatment of all family members.

When ascariasis, trichuriasis, hookworm disease, teniasis, strongyloidiasis and mixed helminthiasis - 100 mg in the morning and evening for 3 days. When trichinosis - 200-400 mg 3 times / day for 3 days, from 4th to 10th day - 400-500 mg 3 times / day. When echinococcosis - 500 mg 2 times / day in the first 3 days, then the same dose 3 times / day in the next 3 days. Later Mebendazole used in doses of 25-30 mg / kg / day in 3-4 doses.

Mebendazole side effects, adverse reactions

Digestive system: rarely - nausea, abdominal pain; when used in high doses for long periods of time may be vomiting, diarrhea, transient elevation of liver enzymes in serum.

CNS: Rarely - dizziness when used in high doses for long periods of time - a headache.

Hematopoietic system: when used in high doses for long periods of time may be leukopenia, anemia, eosinophilia.

Urinary system: when used in high doses for long periods of time - hematuria, cylindruria.

Other: when used in high doses for long periods of time - an allergic reaction, hair loss.

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Mebendazole contraindications

Pronounced liver disfunctions, pregnancy, lactation, children under 2 years of age, hypersensitivity to Mebendazole.

Using during pregnancy and breastfeeding

Mebendazole is contraindicated during pregnancy and lactation (breastfeeding).

Category of the fetus by FDA - C.

Special instructions

With prolonged use of Mebendazole it is necessary to control the peripheral blood picture, liver and kidney function.

Within days after taking Mebendazole avoid drinking alcohol.

After receiving Mebendazole do not use a laxative.

It is mandatory a periodic examination of smears of the anal region and the feces after treatment.

Mebendazole drug interactions

Mebendazole reduces insulin requirements in diabetic patients.

It is necessary to avoid a simultaneously taking of Mebendazole with lipophilic substances. With simultaneous use with cimetidine it may increase, and carbamazepine, and other inducers of metabolism to reduce the concentration of Mebendazole in the blood.

Mebendazole in case of emergency / overdose

Symptoms: nausea, vomiting, diarrhea, abdominal pain. With prolonged use at high doses: reversible hepatic dysfunction, hepatitis, neutropenia.

Treatment: gastric lavage, enemas, activated charcoal method; there is no specific antidote.

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Mebendazole pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Mebendazole available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Mebendazole 100 mg Chew Tabs16.42 USD
Mebendazole 100 mg tablet chew5.32 USD
Mebendazole powder5.03 USD
Suspension; Oral; Mebendazole 100 mg / 5 ml
Tablets, Chewable; Oral; Mebendazole 100 mg
Tablets; Oral; Mebendazole 100 mg
Vermox 100 mg Chewable Tablet4.14 USD

Mebendazole destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Mebendazole Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Mebendazole pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."VERMOX (MEBENDAZOLE) TABLET, CHEWABLE [JANSSEN PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."MEBENDAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "mebendazole". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Mebendazole?

Depending on the reaction of the Mebendazole after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Mebendazole not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Mebendazole addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Mebendazole, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Mebendazole consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Mebendazole drug as prescribed by the doctor?

Few medications can be taken 3 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Mebendazole is mentioned below.
Visitors%
3 times in a day1
100.0%

One visitor reported doses

What is the dose of Mebendazole drug you are taking?
According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
51-100mg1
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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