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DRUGS & SUPPLEMENTS
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Manomazole
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Manomazole uses
Pharmacological action
Manomazole is an antifungal agent of imidazole derivatives group for topical use. This medication has an effect at the expense of the synthesis of ergosterol, which is part of the cell membrane of fungi. Manomazole has a broad spectrum of action.
Manomazole is active against dermatophytes, molds, fungi of the genus Candida, Malassezia furfur.
This drug is also active against Corynebacterium minutissimum, Streptococcus spp., Staphylococcus spp., Trichomonas vaginalis.
Pharmacokinetics
For external use Manomazole is well into the various layers of the skin reaching therapeutic concentrations. When this medication applied topically a small amount of it absorbed into the bloodstream.
Why is Manomazole prescribed?
Fungal skin and mucous membranes: ringworm, tinea, trichophytosis, athlete, mikrosporiya, candidiasis, a fungal interdigital erosion, fungal paronychia; fungal infections complicated by a secondary pyoderma; colorful lichen, erythrasma; thrush; Candida vulvitis, vulvovaginitis, balanitis, trichomoniasis; for the renovation of the birth canal before delivery.
Dosage and administration
When Manomazole used externally it applied to affected skin 2-3 times / day in 2-4 weeks.
For local orally this medicine used 1-2 times / day, no more than 7 days.
Intravaginal - on 100-500 mg for 1-6 days.
Manomazole side effects, adverse reactions
Local reactions: contact allergic dermatitis, redness, burning sensation.
When applied topically to the skin: erythema, blisters, swelling, burning and tingling, irritation and flaking skin.
When applied topically for the treatment of urogenital infections: itching, burning, redness and swelling of the mucous membrane, vaginal discharge, frequent urination, intercurrent cystitis, burning sensation in the penis with a partner, pain during sexual intercourse.
When applied topically in the oral cavity: redness of the oral mucosa, burning sensation and tingling at the site of application, irritation.
Manomazole contraindications
Hypersensitivity to Manomazole, I trimester of pregnancy.
Using during pregnancy and breastfeeding
In experimental studies there have been found that Manomazole used in high doses exerts embryotoxic effect.
It is not known whether Manomazole released in breast milk. Although Manomazole is not contraindicated during pregnancy and lactation, it should be considered a potential risk when selecting antifungal therapy.
Special instructions
Prescribed intravaginal Dosage forms of Manomazole is not used during menstruation.
To prevent reinfection it should be simultaneous treatment of sexual partners.
Manomazole is not recommended for use in ophthalmology.
Manomazole drug interactions
Simultaneous administration of Manomazole with amphotericin B, nystatin, natamycin activity of Manomazole decreases.
Manomazole in case of emergency / overdose
Symptoms: anorexia, nausea, vomiting, stomachodynia, abnormal liver function, rarely - drowsiness, hallucinations, thamuria, allergic skin reactions.
Treatment: taking activated charcoal, symptomatic therapy.
Manomazole pharmaceutical active ingredients containing related brand and generic drugs:
Manomazole available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.