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DRUGS & SUPPLEMENTS
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Macrozit
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Macrozit uses
Pharmacological action
Macrozit is a macrolide antibiotic of azalides group. Macrozit inhibits RNA-dependent protein synthesis of sensitive microorganisms.
It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. ; gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.
Pharmacokinetics
Macrozit rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of Macrozit. Cmax in plasma is reached after 2-3 hours. This medicine rapidly distributed in tissues and biological fluids. 35% of the Macrozit is metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% in the urine in unchanged form.
Why is Macrozit prescribed?
Infectious-inflammatory diseases caused by microorganisms susceptible to Macrozit, including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non gonorrheal urethritis and / or cervicitis, Lyme disease.
Dosage and administration
Dosage of Macrozit is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.
Macrozit side effects, adverse reactions
Digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes, rarely - cholestatic jaundice.
Allergic reactions: rarely - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Dermatological reactions: rarely - photosensitization.
CNS: dizziness, headache, rarely - drowsiness, weakness.
Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.
Cardiovascular system: rarely - chest pain.
Urogenital system: vaginitis, rarely - candidiasis, nephritis, increased residual nitrogen urea.
Other: rarely - hyperglycemia, arthralgia.
Contraindications
Hypersensitivity to Macrozit and other macrolide antibiotics.
Using during pregnancy and breastfeeding
Macrozit crosses the placental barrier. Use in pregnancy only in cases where the intended benefits to the mother outweighs the potential risk to the fetus.
If necessary to use Macrozit in the lactation period should solve the issue of termination of breastfeeding.
Special instructions
Macrozit not recommended for use in patients with compromised liver function.
Macrozit uses with careful with impaired renal function.
This medication should be taken at least 1 hour before or 2 hours after eating or taking of antacids.
Macrozit drug interactions
Simultaneous administration of Macrozit with these drugs and medications may has followed effects:
Macrozit pharmaceutical active ingredients containing related brand and generic drugs:
Macrozit available forms, composition, doses:
Macrozit destination | category:
Macrozit Anatomical Therapeutic Chemical codes:
Macrozit pharmaceutical companies:
References
- Dailymed."ZITHROMAX (AZITHROMYCIN DIHYDRATE) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [PFIZER LABORATORIES DIV PFIZER INC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."AZITHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "azithromycin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Macrozit?Depending on the reaction of the Macrozit after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Macrozit not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Macrozit addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Macrozit, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Macrozit consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetOne visitor reported frequency of use
How often in a day do you take the medicine?Are you taking the Macrozit drug as prescribed by the doctor?
Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Macrozit is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Twice in a day | 1 | 100.0% | |
Five visitors reported doses
What is the dose of Macrozit drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 201-500mg | 4 | 80.0% | |
| 101-200mg | 1 | 20.0% | |
Visitor reported time for results
No survey data has been collected yetVisitor reported administration
No survey data has been collected yetOne visitor reported age
| Visitors | % | ||
|---|---|---|---|
| 46-60 | 1 | 100.0% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology