Lorazepam preservative free

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Lorazepam preservative free uses

Pharmacological action

Lorazepam preservative free is an anxiolytic drug, a derivative of benzodiazepine. This medication has anxiolytic, sedative, hypnotic, anticonvulsant, muscle relaxant central, antiemetic effect. The mechanism of the anxiolytic, sedative and hypnotic action is associated with increased inhibitory effect of GABA in the CNS. Anticonvulsant action, apparently in part due to increased presynaptic inhibition; inhibited the spread of epileptogenic activity arising in the epileptogenic foci in the cortex, thalamus and limbic structures, but not removed the excited state of the hearth. Muscle relaxant effect is primarily associated with the suppression of spinal polysynaptic afferent pathways and, presumably, an inhibition of monosynaptic afferent pathways; possibly also a direct inhibitory effect on motor nerves and muscle function.


After oral administration the bioavailability of Lorazepam preservative free is 95-99%. The plasma proteins binding is about 80%. Vd is 1.3 L / kg. Lorazepam preservative free is metabolized in the liver by conjugation to form inactive metabolites. T1/2 is 8-15 h. This medicine is derived primarily by the kidneys.

Why is Lorazepam preservative free prescribed?

Anxiety, sleep disturbances due to anxiety or transient stressful situation, neuroses and neurosis-like states, panic disorder, endogenous psychoses: mania, catatonic state, anxiety and excitement in schizophrenia; acute alcoholic delirium; premedication in anesthesia, epilepsy (in combination therapy), status epilepticus; symptomatic convulsive status; psychosomatic disorders and headaches.

Dosage and administration

For oral administration for adults and adolescents the dose is 0.5-4 mg 1-3 times / day. In IV or IM introduction a single dose is 50 mg / kg, the dose frequency is set depending on the evidence and the clinical situation.

The maximum daily dose when Lorazepam preservative free administered orally is 10 mg, for IV and IM injections a single dose is 4 mg.


Lorazepam preservative free side effects, adverse reactions

CNS: rarely - dizziness, ataxia, fatigue, muscle weakness; in some cases - the episodes of amnesia.

Digestive system: rarely - dry mouth, dysphagia, nausea, diarrhea, constipation, appetite disorders; in some cases - liver function abnormalities.

Allergic reactions: rarely - skin rash, itching.

Laboratory parameters: changes in peripheral blood.

Local reactions: for IV injections can be phlebitis or venous thrombosis.

Lorazepam preservative free contraindications

Myasthenia gravis, angle-closure glaucoma, acute intoxication with psychotropic drugs, acute alcohol intoxication, increased sensitivity to Lorazepam preservative free.

Using during pregnancy and breastfeeding

During pregnancy, especially in the I trimester, apply Lorazepam preservative free only under strict indications. Lorazepam preservative free and / or its metabolites are excreted in breast milk. provision. It should be borne in mind that newborns benzodiazepines metabolized more slowly than adults, therefore it is possible accumulation of the active substance and / or its metabolites in the body of the child.

Special instructions

With extreme caution Lorazepam preservative free is used in closed-angle glaucoma is suspected, severe chronic obstructive pulmonary disease, in a coma, shock, epilepsy, renal dysfunction, hyperkinesis, hypoproteinemia, severe depression, organic brain disease, porphyria, psychosis with suspected sleep apnea.

The development of adverse reactions are more likely at the beginning of treatment and in cases of exceeding the recommended doses.

With prolonged use of Lorazepam preservative free may develop addiction and drug dependence.

In the case of using this medication for sedation it may be required reducing the dose of fentanyl derivative used for induction of anesthesia, and it is possible a reduction of time before the mind with induction doses.

Patients receiving Lorazepam preservative free should refrain from activities in potentially hazardous activities that require attention and psychomotor speed of reaction.

Lorazepam preservative free drug interactions

When this drug applied simultaneously with:

- drugs which have a depressing effect on the CNS, with alcohol, alcohol containing drugs increased inhibitory effect on the CNS.

- Lorazepam preservative free and alcohol may develop agitation, aggression, pathological intoxication.

- diminishes the effectiveness of oral contraceptives.

- enhanced effect of depolarizing relaxants.

- nicotine increases the metabolism of Lorazepam preservative free, and decreases its activity.

- probenecid may interfere with the binding of Lorazepam preservative free with glucuronic acid, resulting in higher concentrations in blood plasma, and by enhancing the therapeutic effect may develop excessive sedation.

Lorazepam preservative free in case of emergency / overdose

Symptoms: drowsiness, hypotension, confusion, depression of reflexes, coma.

Treatment: induction of vomiting, gastric lavage, IV introduction of norepinephrine to increase blood pressure, symptomatic therapy, monitoring of vital functions. The introduction of a specific antidote - an antagonist of benzodiazepine receptors flumazenil (in hospital).


Lorazepam preservative free pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

Lorazepam preservative free available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Lorazepam preservative free destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

Lorazepam preservative free Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

Lorazepam preservative free pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



  1. Dailymed."LORAZEPAM CONCENTRATE [AMNEAL PHARMACEUTICALS, LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."LORAZEPAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "lorazepam". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Lorazepam preservative free?

Depending on the reaction of the Lorazepam preservative free after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Lorazepam preservative free not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Lorazepam preservative free addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.



sdrugs.com conducted a study on Lorazepam preservative free, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Lorazepam preservative free consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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