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Leflunomide uses

Leflunomide information

This medication, with the generic name of Leflunomide, is specially formulated to provide physical relief from inflammation, swelling, stiffness, and joint pain as caused by rheumatoid arthritis. Leflunomide acts by stopping the production of too much immune cells causing inflammation and swelling in the body.

Leflunomide indications

Leflunomide is prescribed to patients showing signs of rheumatism as listed below:




Joint pain

Leflunomide warnings / precautions

It is best to have a discussion with your doctor prior to taking Leflunomide as there may be cases when it is not advisable to take the drug. Let your doctor know of any allergy from food, preservatives, dyes, or other substances, and if you are experiencing medical conditions such as:

Disease of the immune system

Serious infections - this drug may lessen the body's ability to combat infection

Liver disease including Hepatitis B or C

Renal disease - May increase the chance of side effects

Leflunomide is not safe for use by pregnant women. It contains chemicals that may be harmful to the unborn baby and may result to birth defects. Women of childbearing age are also suggested to use only safe and reliable contraceptives before incurring this medication.

It is uncertain if Leflunomide passes into breast milk. Nonetheless, nursing moms are not advised to take this drug.

Children, 18 years of age and below, are prohibited of taking Leflunomide though there is not enough information provided as to its effects compared with other age groups. Likewise, it is not known how Leflunomide works for the elderly as it has not been specifically studied for older adults. Various side effects and other problems may arise.

Men taking Leflunomide are also recommended to use condoms during sexual intercourse as a form of birth control. No study has been done to answer as to how Leflunomide may affect children of men taking the drug at the time of conception. In case you decide to father a child, have a talk with your doctor and stop this medication.


Leflunomide intake instructions

Average oral dosage for rheumatoid arthritis:

Adults - 100mg once a day for three days, then 20mg once a day

Children - Dosage is decided by the doctor

Leflunomide must be taken as indicated in the label. However, the dose may differ from every patient. Do not change the dose unless directed by your doctor.

Leflunomide missed dose

Take the missed dose as soon as possible. Should you forget to take the scheduled dosage until the following day, skip it and proceed with the next one. Leflunomide must not be double dosed.

Leflunomide overdose

If symptoms of Overdosage are suspected, consult your doctor for the proper medical action.

Leflunomide side effects

Consult your doctor if you experience any of these unwanted effects

Bloody or cloudy urine

Chest congestion


Difficult, burning, or painful urination

Difficulty or pain in breathing



Frequent urge to urinate


Loss of appetite

Nausea and / or vomi ting


Sore throat

Yellow eyes and / or skin

Less Common,

Burning feeling in the chest or stomach

Burning, prickling, or tingling sensation in the fingers and / or toes

Chest pain


Fast heartbeat


Joint or muscle pain or stiffness

Pounding heartbeat

Severe stomach pain

Shortness of breath

Tenderness in the stomach area

Unusual tiredness or weakness

Other side effects may likely arise. These are expected as the body adjusts to the medication. However, should these conditions continue to be bothersome, see your doctor.

More Common,

Back pain

Hair loss


Skin rash

Stomach pain

Unexplained weight loss

Less Common,




Decreased appetite

Dry mouth


Irritation or soreness of the mouth

Skin itching

Pain or burning in the throat

Red or irritated eyes

Runny nose

For other side effects that you may experience and is not included in the list, talk with your doctor.

Leflunomide Drug Interactions

Refrain from drinking alcohol while taking this medication. It can increase the chance of having liver problems.

Do not have immunizations or vaccinations without consulting your doctor first while under medication or after treatment of Leflunomide Sanis Health.

Tell your doctor if you are taking other prescribed or over-the-counter medicines. Change of dose or additional precautions may be necessary.


Leflunomide pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

Leflunomide available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Arava 10 mg tablet24.76 USD
Arava 20 mg tablet24.76 USD
Leflunomide 10 mg tablet16.75 USD
Leflunomide 20 mg tablet16.75 USD
Tablets; Oral; Leflunomide 10 mg
Tablets; Oral; Leflunomide 20 mg

Leflunomide destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

Leflunomide Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

Leflunomide pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



  1. Dailymed."LEFLUNOMIDE TABLET [NORTHSTAR RXLLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."LEFLUNOMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "leflunomide". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Leflunomide?

Depending on the reaction of the Leflunomide after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Leflunomide not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Leflunomide addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.



sDrugs.com conducted a study on Leflunomide, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Leflunomide consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Leflunomide drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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