DRUGS & SUPPLEMENTS
Ketoprofene is a NSAID, propionic acid derivative. This medication has analgesic, anti-inflammatory and antipyretic activity. The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. A pronounced analgesic effect of Ketoprofene is due to two mechanisms: peripheral and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system, as well as the influence on the biological activity of other neurotrophic substances that play a key role in the release of neurotransmitters in the spinal pain brain). In addition, this drug has anti-bradykinin activity, stabilizes lysosomal membranes, causes a significant inhibition of neutrophils in patients with rheumatoid arthritis.
After oral and rectal administration Ketoprofene is well absorbed from the gastrointestinal tract. Cmax in plasma by ingestion is achieved through 1-5 hours (depending on dosage form), with rectal administration - after 45-60 min; IM administration - after 20-30 min; IV injections - after 5 minutes.
The plasma protein binding is 99%. Due to the lipophilicity expressed rapidly penetrates the BBB. Css in plasma and cerebrospinal fluid stored between 2 and 18 h.
Ketoprofene well penetrates into synovial fluid, where its concentration is 4 hours after admission exceeds that in plasma.
This medicine is metabolized by binding to glucuronic acid and to a lesser extent by hydroxylation.
Ketoprofene is excreted primarily by kidneys and to a lesser extent through the intestines. T1/2 of Ketoprofene from plasma after oral administration is 1.5-2 h; after rectal administration - about 2 hours; IM administration - 1.27 hours, IV injections - 2 hours.
Why is Ketoprofene prescribed?
Articular syndrome ; symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal (shoulder, artrosinovit, tendonitis, tenosynovitis, bursitis, lumbago), back pain, neuralgia, myalgia. Uncomplicated trauma, particularly sports, sprains, sprain or rupture of ligaments and tendons, bruises, post-traumatic pain. As part of combination therapy of inflammatory diseases of veins, lymphatic vessels, lymph nodes (phlebitis, periflebit, lymphangitis, lymphadenitis surface).
Dosage and administration
The dosage regimen set individually according to the severity of the disease. For oral administration in adult the initial daily dose is 300 mg in 2-3 doses. For maintenance treatment the dose depends on the dosage form. For the treatment of acute conditions or exacerbations of chronic edema of the process this medication is administered in 100 mg as a single IM injection. Next Ketoprofene administered orally or rectally.
Topically this drug used to the skin surface 2 times / day.
The maximum dose oral or rectal administration is 300 mg / day.
Ketoprofene side effects, adverse reactions
Digestive system: epigastric pain, nausea, vomiting, constipation or diarrhea, anorexia, gastralgia, liver, rarely - erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding and perforation.
CNS: headache, dizziness, tinnitus and drowsiness.
Urinary system: kidney damage.
Allergic reactions: skin rash, rarely - bronchospasm.
Local reactions: when Ketoprofene used in rectal suppositories it is possible irritation of the mucous membrane of the rectum, painful defecation, when this medication used in a gel form - itching, skin rash at the site of application.
For oral administration: erosive and ulcerative lesions of the gastrointestinal tract in acute phase, "aspirin triad" expressed by the human liver and / or kidney disease; III trimester of pregnancy; age up of 15 years ; increased sensitivity to Ketoprofene and salicylates.
For rectal administration: proctitis and bleeding from the rectum in history.
For external use: moist dermatitis, eczema, infected abrasions and wounds.
Using during pregnancy and breastfeeding
Ketoprofene is contraindicated for use in the III trimester of pregnancy. In I and II trimesters of pregnancy the use of Ketoprofene may be in cases when the potential benefit to the mother outweighs the potential risk to the fetus.
If necessary to use Ketoprofene in lactating a breast-feeding should be stopped
.Category of the fetus by FDA - C.
With great caution use Ketoprofene in patients with liver and kidney, gastrointestinal tract diseases in the history of dyspeptic symptoms after major surgery. In the course of treatment it requires systematic monitoring of liver and kidney.
Ketoprofene drug interactions
When this drug applied simultaneously with:
- other NSAIDs increases the risk of erosive and ulcerative lesions of the gastrointestinal tract and bleeding
- antihypertensive drugs it may decreases their actions
- aspirin may decrease the binding of Ketoprofene to plasma proteins and increase its plasma clearance
- heparin, ticlopidine increase risk of bleeding
- lithium therapy - it may increase the concentration of lithium in blood plasma to the toxic by reducing its renal excretion
- diuretics increases the risk of renal failure due to a decrease in renal blood flow caused by inhibition of prostaglandin synthesis, and against the background of hypovolemia
- probenecid it may decreases the clearance of Ketoprofene and its binding to plasma proteins
- methotrexate - may increase the side effects of methotrexate
- warfarin may develop severe, sometimes fatal bleeding.
Ketoprofene in case of emergency / overdose
Symptoms: lethargy, dizziness, nausea, vomiting, epigastric pain - these symptoms are usually reversible. May be respiratory distress, coma, convulsions. Rarely - bleeding from the gastrointestinal tract, hypotension / hypertension, acute renal failure.
Treatment: symptomatic and supportive therapy, monitoring of respiratory and cardiovascular systems. The is no a specific antidote. Hemodialysis is ineffective.
Ketoprofene pharmaceutical active ingredients containing related brand and generic drugs:
Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.
Ketoprofene available forms, composition, doses:
Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.
Ketoprofene destination | category:
Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.
Ketoprofene Anatomical Therapeutic Chemical codes:
A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.
Ketoprofene pharmaceutical companies:
Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.
Frequently asked QuestionsCan i drive or operate heavy machine after consuming Ketoprofene?
Depending on the reaction of the Ketoprofene after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ketoprofene not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Ketoprofene addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
ReviewsDrugs.com conducted a study on Ketoprofene, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ketoprofene consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.
One visitor reported frequency of useHow often in a day do you take the medicine?
Are you taking the Ketoprofene drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Ketoprofene is mentioned below.
The information was verified by Dr. Arunabha Ray, MD Pharmacology