Isoacne

How often in a day do you take medicine? How many times? Once in a day Twice in a day 3 times in a day 4 times in a day

Isoacne uses

• Pharmacological action
• Pharmacokinetics
• Why is Isoacne prescribed?
• Dosage and administration
• Isoacne side effects, adverse reactions
• Isoacne contraindications
• Using Isoacne during pregnancy and lactation
• Special instructions
• Isoacne drug interactions
• Isoacne reviews

Pharmacological action

Isoacne is a pharmaceutical agent for the treatment of acne. Contributes to the normalization of terminal cell differentiation, inhibits the hyperproliferation of the epithelium of excretory ducts of the sebaceous glands, the formation of detritus and makes it easier to evacuate. Due to this reduced production of sebum and facilitates its isolation, normal structure, decreasing the inflammatory reaction around the glands. For external and systemic application Isoacne has antiseborrhea, sebostatic, anti-inflammatory, keratitis and immunomodulatory actions, strengthens the processes of regeneration in the skin.

Pharmacokinetics

When Isoacne administered orally Isoacne is absorbed from the gastrointestinal tract, absorption may increase when taken with food. C_max plasma levels reached after 1-4 hours after ingestion.

Oral bioavailability of Isoacne is low which may be caused by parietal metabolism in the intestinal wall and the effect of "first passage" through the liver.

Isoacne is highly bound to plasma proteins. Metabolized in the liver with the formation of the main metabolite 4-oxo-isotretinoin, also there is some isomerization of Isoacne in tretinoin.

Isoacne, tretinoin and its metabolites are enterohepatic recycling.

The end of T1/2 of tretinoin is 10-20 hours. An equivalent amount is determined in the feces, mostly unchanged, and urine in the form of metabolites.

Why is Isoacne prescribed?

For Isoacne oral administration: severe nodular-cystic acne especially with the localization on the body.

For rectal administration: severe relapsing forms of acne, rashes associated with seborrheic process.

For external use: papule-pustular acne, seborrhea, rosacea, perioral dermatitis.

Dosage and administration

For oral administration initial dose of Isoacne is 500 mcg / kg / day; the maximum daily dose used for a limited time and is 1 mg / kg; the maintenance dose is 0.1-1 mg / kg / day; duration of treatment is 16 weeks, a second course conducted at intervals of 8 days. Isoacne is taken with meals in one or more receptions.

Rectal - 0.5-1 mg / kg / day, one time at night ; course of treatment - 8-12 weeks, the intervals between courses - 1-2 months.

Ointment applied thinly to the affected areas of skin 2 times / day. Duration of treatment - 4-6 weeks.

Isoacne side effects, adverse reactions

Dermatological reactions: dry mucous membranes, skin rashes, dermatitis, pruritus, cheilitis, erythema (especially on the face), sweating, palmar-plantar desquamation and paronychia, nail dystrophy, increased proliferation of granulation tissue in the affected area, rarely - thinning hair, vasculitis, photosensitivity.

Senses: conjunctivitis, photophobia, decreased night vision, corneal opacity, weakening of the hearing.

CNS and peripheral nervous system: headache, rarely - depression, seizures, suicide, and in rare cases - intracranial hypertension.

Digestive system: nausea, rarely - colitis, bleeding from the gastrointestinal tract, transient elevation of liver transaminases and in rare cases - hepatitis.

Hematopoietic system: anemia, neutropenia, changes in platelet count, increased erythrocyte sedimentation rate.

Metabolism: increased concentrations of TG and glucose.

Musculoskeletal system: pain in muscles and joints, rarely - hyperostosis.

Other: nasal bleeding.

Rectal and topical using: 1-2 weeks of treatment may cause new eruptions, itching, swelling and redness.

Isoacne contraindications

Pregnancy, established and planned lactation, hypersensitivity to Isoacne, the simultaneous use of tetracycline antibiotics.

For oral administration: severe liver and / or kidney damage, hypervitaminosis A, significantly elevated levels of lipids in blood plasma, neoplasms.

For rectal use - diseases of the rectum.

Using Isoacne during pregnancy and lactation

Isoacne has a pronounced teratogenic and embryotoxic action.

Isoacne is contraindicated in established and planned pregnancy.

Also Isoacne is contraindicated during lactation.

Special instructions

Rectally and topically applied with caution in liver disease, kidney disease, chronic pancreatitis, decompensation of heart function, chronic intoxication.

Rectal and external use in a pronounced exacerbation of the reaction (on 1-2-week treatment) is recommended to cancel the medication for a few days before its decline, then therapy can be resumed.

For oral administration requires regular monitoring of liver function and lipid levels in blood plasma before treatment, 1 month after initiation of therapy and then every 3 months.

In diabetes, obesity, alcoholism or lipid metabolism violations recommended more frequent monitoring of laboratory parameters. In diabetes mellitus or suspected it is necessary to strictly control glucose levels in plasma.

With prolonged use may develop symptoms of chronic hypervitaminosis A.

During treatment or within a certain time after its completion can not be donors for women of childbearing age.

During the treatment, patients should not be given UV treatment, patients should avoid direct exposure to sunlight.

In the course of treatment with Isoacne may occur intolerance of contact lenses.

Safety of children and prepubertal patients has not been established.

Should avoid the simultaneous use of Isoacne and 19-nortestosterone derivatives, particularly in patients with gynecological / endocrine diseases.

Not recommended for concurrent use of other drugs with keratolytic or exfoliative properties (including other retinoids), and progesterone in the microdose (including drugs "mini-pilly").

Isoacne drug interactions

The action of Isoacne is weakened by the simultaneous application of progesterone in the microdose.

With the simultaneous application of Isoacne and vitamin A may increase toxic effects.

With the simultaneous application of Isoacne and aminoglycoside antibiotics is at risk of developing intracranial hypertension.

Isoacne pharmaceutical active ingredients containing related brand and generic drugs:

• Isotretinoin

Isoacne available forms, composition, doses:

• N/A

Isoacne destination | category:

• Human:
• Acne treatment preparations
• Skin and mucous membrane agents

Isoacne Anatomical Therapeutic Chemical codes:

• D10AD04 - Isotretinoin
• D10BA01 - Isotretinoin

Isoacne pharmaceutical companies:

• Schering-Plough

References

1. Dailymed."SOTRET (ISOTRETINOIN) CAPSULE, GELATIN COATED SOTRET (ISOTRETINOIN) CAPSULE, LIQUID FILLED [RANBAXY LABORATORIES INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
2. Dailymed."ISOTRETINOIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
3. "Isotretinoin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Isoacne?

Depending on the reaction of the Isoacne after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Isoacne not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Isoacne addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

Review

sdrugs.com conducted a study on Isoacne, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Isoacne consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reviews

There are no reviews yet. Be the first to write one!

Your name:  Email:  Spam protection:  < Type 11 here

The information was verified by Dr. Rachana Salvi, MD Pharmacology