Insomin

Rating: 1.65 - 3 review(s)
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What are the side effects you encounter while taking this medicine?

Insomin uses


Pharmacological action

Insomin is an hypnotic drug from benzodiazepines group. This medication has a marked sedative effect, anxiolytic, sedative, anticonvulsant and central muscle relaxant effect. The mechanism of action is associated with increased inhibitory effect of GABA in the CNS by increasing the sensitivity of the GABA-receptor mediator as a result of stimulation of benzodiazepine receptors. Insomin increases the depth and duration of sleep. Sleep usually occurs in 20-40 minutes after ingestion and lasts for 6-8 hours. Moderately inhibits the phase of the quick sleep.

Pharmacokinetics

The plasma protein binding is more than 80%. Vd is 1.9 L / kg. T1/2 is an average of 26 hours. Insomin is excreted mainly as metabolites.

Why is Insomin prescribed?

Sleep disorders of various origins, somnambulism, premedication before surgery, encephalopathy, accompanied by epileptic seizures.

Dosage and administration

The daily dose for adults is ranged from 2.5 mg to 25 mg; the multiplicity of usind is set individually. The daily dose for children is 0.6-1 mg.

Insomin side effects, adverse reactions

CNS and peripheral nervous system: fatigue, impaired concentration, psychomotor retardation reactions, muscle weakness; rarely - headaches, ataxia, confusion, amnesia, depression, blurred vision, in predisposed patients may be worsening of suicidal thoughts, hallucinations.

Cardiovascular system: rarely - hypotension.

Digestive system: rarely - dry mouth, nausea, diarrhea.

Respiratory system: patients with obstructive pulmonary disease possible respiratory depression.

Reproductive system: changes in libido.

Allergic reactions: seldom - a skin rash, itching.

Insomin contraindications

Acute respiratory failure, drug or alcohol dependence, myasthenia gravis, temporal lobe epilepsy, angle-closure glaucoma, acute intoxication with drugs, providing a depressing effect on the central nervous system or alcohol abuse, hypersensitivity to benzodiazepines.

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Using during pregnancy and breastfeeding

There was not conducted adequate and well-controlled studies safety of Insomin during pregnancy and lactation. Insomin is contraindicated especially in I and III trimester of pregnancy.

If necessary Insomin using during lactation breastfeeding should be discontinued.

Special instructions

Insomin should be used with caution in severe respiratory failure, obstructive pulmonary disease, ataxia, sleep apnea, marked hepatic dysfunction.

With prolonged use may develop drug dependence.

During the period of treatment avoid taking alcohol.

During the period of treatment patients should refrain from activities potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Insomin drug interactions

Simultaneous administration of Insomin with:

  • drugs providing a depressing effect on the CNS, with ethanol, ethanol containing drugs is enhanced inhibitory effect on the CNS.
  • anticonvulsant drugs may mutual enhancement of toxic effects.
  • Insomin potentiates the action of antihypertensive drugs.
  • estrogen containing oral contraceptives increases the concentration in blood plasma Insomin.
  • probenecid may interfere with the glucuronide binding of Insomin that leads to an increase in its concentration in plasma and by enhancing the therapeutic effect may develop excessive sedation.
  • rifampicin increased excretion from the body of Insomin
  • cimetidine increases the concentration of nitrazepama in blood plasma, which may be accompanied by increased sedation. It may be slow the hepatic metabolism of Insomin. This can lead to a lengthening of T1/2 of Insomin and for long-term use - an increase of its concentration in blood plasma.

    Insomin in case of emergency / overdose

    Symptoms: CNS depression of varying severity - lethargy, weakness, severe drowsiness, deep sleep, confusion, decreased response to painful stimuli; in more severe cases - ataxia, areflexia, hypotension, respiratory depression and cardiac activity, coma.

    Treatment: induction of vomiting or gastric lavage, activated charcoal technique, monitoring vital signs, symptomatic therapy, intravenous fluids, if necessary - mechanical ventilation. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital).

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    Insomin pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Insomin available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Insomin destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Insomin Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Insomin pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. "nitrazepam". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    2. "nitrazepam". http://www.drugbank.ca/drugs/DB0159... (accessed August 28, 2018).
    3. "9CLV70W7HS: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Dat... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Insomin?

    Depending on the reaction of the Insomin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Insomin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Insomin addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Insomin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Insomin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Two visitors reported useful

    How is the drug Insomin useful in reducing or relieving the symptoms? How useful is it?
    According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
    Visitors%
    Not useful1
    50.0%
    Useful1
    50.0%

    One visitor reported side effects

    Did you get side effects while taking the Insomin drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Insomin medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    It has side effects1
    100.0%

    Visitor reported price estimates

    No survey data has been collected yet

    One visitor reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Insomin drug as prescribed by the doctor?

    Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Insomin is mentioned below.
    Visitors%
    Once in a day1
    100.0%

    Two visitors reported doses

    What is the dose of Insomin drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    11-50mg2
    100.0%

    Visitor reported time for results

    No survey data has been collected yet

    Visitor reported administration

    No survey data has been collected yet

    Three visitors reported age

    Visitors%
    30-452
    66.7%
    16-291
    33.3%

    Visitor reviews


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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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