Inmecin-P

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What are the side effects you encounter while taking this medicine?

Inmecin-P uses

Inmecin-P consists of Acetaminophen, Indometacin.

Acetaminophen:


Pharmacological action

Inmecin-P is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.

Why is Inmecin-P (Acetaminophen) prescribed?

Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.

Inmecin-P dosage and administration

Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.

Maximum dose: single - 1 g, daily - 4 g.

Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.

Maximum dose: 4 single dose per day.

Inmecin-P side effects, adverse reactions

Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.

Contraindications

Chronic active alcoholism, increased sensitivity to Inmecin-P, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).

Using during pregnancy and breastfeeding

Inmecin-P (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Inmecin-P (Acetaminophen) on the fetus in humans.

Inmecin-P (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.

If necessary, use of Inmecin-P (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.

In experimental studies found no embryotoxic, teratogenic and mutagenic action of Inmecin-P (Acetaminophen).

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Special Instructions

Inmecin-P is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.

With prolonged use of Inmecin-P (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.

Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).

Inmecin-P (Acetaminophen) Drug Interactions

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Inmecin-P (Acetaminophen).

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Inmecin-P (Acetaminophen).

With the simultaneous use of oral contraceptives accelerated excretion of Inmecin-P (Acetaminophen) from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Inmecin-P (Acetaminophen).

When Inmecin-P (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Inmecin-P (Acetaminophen). A case of severe toxic liver injury.

Described cases of toxic effects of Inmecin-P (Acetaminophen), while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Inmecin-P (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Inmecin-P (Acetaminophen) and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Inmecin-P (Acetaminophen) may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Inmecin-P (Acetaminophen) and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Inmecin-P (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Inmecin-P (Acetaminophen) due to increasing its metabolism in the liver.

At simultaneous application of Inmecin-P (Acetaminophen) with ethinylestradiol increases absorption of Inmecin-P (Acetaminophen) from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Inmecin-P in case of emergency / overdose

At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.

Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms

Indometacin:


Inmecin-P information

Inmecin-P (Indometacin) is a non-steroidal anti-inflammatory drug, typically prescribed in order to manage symptoms such as pain, fever, swelling and stiffness. This medication acts as an inhibitor of prostaglandin production - prostaglandins are the agents that are known to induce these symptoms.

Inmecin-P indications

There are several medical conditions for which Inmecin-P (Indometacin) may be prescribed, including rheumatoid arthritis, ankylosing spondylitis, arthritic gout, juvenile arthritis, osteoarthritis and psoriatic arthritis. Apart from these, this drug has shown positive results when prescribed for the treatment of Reiter's syndrome, Bartter syndrome and Paget's disease. Inmecin-P (Indometacin) may also be prescribed for patients that are suffering from pseudogout, pericarditis, dysmenorrheal, bursitis or tendonitis. This drug is also effective for the management of such affections as nephrogenic diabetes insipidus, hemicrania continua, paroxysmal hemicrania and migraine, but it may also be used in the management of symptoms such as pain and fever associated with malignancies (bony metastases, tumors or lymphogranulomatosis). There may be other uses for this medication as well.

Inmecin-P warnings

The intake of Inmecin-P (Indometacin) is not suitable in the case of patients that are suffering from an allergy to this drug, to any of its components, to Aspirin or to other non-steroidal anti-inflammatory medications. Also, this drug should not be employed in the treatment of patients with concurrent peptic ulcers or with severe preexisting liver or kidney damage. In the case of neonates with patent ductus arteriosus, Inmecin-P (Indometacin) should not be employed in the treatment of children of less than 2 years of age.

Caution should be employed in the treatment of patients suffering from Parkinson's disease, psychotic disorders or epilepsy as Inmecin-P (Indometacin) may worsen the symptoms of these conditions. Therapy with this medication may require special consideration when employed in the treatment of patients suffering from bleeding tendencies as Inmecin-P (Indometacin) may inhibit the aggregation of platelets. Frequent blood cell counts clinical evaluations are recommended in the case of patients with preexisting bone marrow damage.

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Inmecin-P intake guidelines

It is highly recommended that the patient closely follows the Inmecin-P (Indometacin) intake guidelines that he or she has been given by the prescribing doctor. In many cases, regular physical examination of the patient may be required, in order to detect early signs of oedema or any possible side effects affecting the central nervous system. Blood pressure should be measured in order to check for hypertension. As part of the regular testing, blood cell counts, serum electrolyte measurements of the sodium, chloride and potassium and assessment of renal and liver functions should be performed, especially in the case of patients that are being administered Inmecin-P (Indometacin) in combination with a potassium-sparing diuretic or an ACE inhibitor; this is useful in order to detect or prevent development of kidney failure or hyperkalemia.

Inmecin-P dosage

The exact Inmecin-P (Indometacin) dosage depends on the medical condition that the individual is being treated for. Apart from that, the examining health care professional will decide the appropriate dosage based on several factors such as the patient's medical history, his or her age as well as general health condition. The Inmecin-P (Indometacin) dosage may vary greatly from one patient to another, so it is highly recommended that you use the exact dosage that has been prescribed in your case.

Inmecin-P overdose

Inmecin-P (Indometacin) has a high factor of acute toxicity in humans, and in some cases an overdose with this drug resulted in the death of the patient. As such, it is highly advised to take the medication dosage that has been prescribed for your case, and never take a higher dose.

Typical symptoms of a Inmecin-P (Indometacin) overdose include dizziness, drowsiness, mental confusion, severe headache, paraesthesia, nausea, vomiting and numbness of limbs. In some cases, severe gastrointestinal bleeding as well as cardiac arrest or cerebral oedema are possible.

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Inmecin-P missed dose

It is highly advised that you set up a regular intake schedule in order to lower the risks of missing a dose of your medication. In the case of Inmecin-P (Indometacin), if you happen to miss a dose it is advised to take it as soon as you remember, unless it is almost time for another dose of the medication. If this is the case, you should completely skip the missed dose and continue with your regular intake schedule; you should bring the matter to the attention of your personal health care provider as soon as possible. He or she will assess the situation and decide on the appropriate course of action to take, if needed.

Inmecin-P side effects

There are several side effects associated with a Inmecin-P (Indometacin) treatment. Treatment with this drug may lead to the appearance of peptic ulcers or other less severe gastrointestinal disturbances such as mild diarrhea, dyspepsia or heartburn. Due to the retention of lithium, patients following a treatment with Inmecin-P (Indometacin) have a higher risk of lithium toxicity. Hypertension, hyperkalemia and hypernatremia as well as oedema are also possible side effects of a therapy with this drug. In up to 20% of the cases, the patients may experience headaches, sometimes together with tinnitus, vertigo, dizziness, hearing loss or blurred vision. Photosensitivity and skin reactions have been reported. In rare cases, Inmecin-P (Indometacin) may cause severe damage to the bone marrow, severe or even lethal hepatitis or potentially fatal shock.

Inmecin-P drug reactions

At this time, there is no exact information regarding the possible interactions between Inmecin-P (Indometacin) and other medications. It is advised that you consult with your personal health care professional and inform him or her about any other medication you are currently taking before starting a treatment with this drug.

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Inmecin-P pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Inmecin-P available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Inmecin-P destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Inmecin-P Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Inmecin-P pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."FEVERALL INFANTS (ACETAMINOPHEN) SUPPOSITORY [ACTAVIS MID ATLANTIC LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "acetaminophen". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Inmecin-P?

Depending on the reaction of the Inmecin-P after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Inmecin-P not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Inmecin-P addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Inmecin-P, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Inmecin-P consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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One visitor reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Inmecin-P drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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