DRUGS & SUPPLEMENTS

Ibuprofen

Rating: 3.75 - 8 review(s)
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When are you taking this medicine?

Ibuprofen uses


Pharmacological action

NSAIDs, a derivative of phenylpropionic acid, Ibuprofen has anti-inflammatory, analgesic and antipyretic effect.

The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. Analgesic effect is due to both peripheral, and a central mechanism (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Inhibits platelet aggregation.

For topical use anti-inflammatory and analgesic action. Reduces morning stiffness, increased the amount of motion in joints.

Pharmacokinetics

When oral administered Ibuprofen almost completely absorbed from the gastrointestinal tract. Simultaneous food intake slows the rate of absorption. Metabolised in the liver (90%). T1 / 2 is 2-3 hours.

80% of the dose excreted in urine mainly as metabolites (70%), 10% - unchanged, 20% eliminated through the intestine in the form of metabolites.

Why is Ibuprofen prescribed?

Inflammatory, degenerative diseases of joints and spine, articular syndrome in patients with acute gout, psoriatic arthritis, ankylosing spondylitis, tendonitis, bursitis, sciatica, traumatic inflammation of soft tissue and musculoskeletal apparatus. Neuralgia, myalgia, pain in infectious and inflammatory diseases of ENT organs, bursitis, algomenorrhea, headache and toothache. Fever in infectious and inflammatory diseases.

Dosage and administration

Setting individually, depending on etiology of disease, severity of clinical manifestations. When administered rectally or adult single dose of 200-800 mg, the frequency of reception - 3-4; for children - 20-40 mg / kg in divided doses.

Topical applied within 2-3 weeks.

The maximum daily dose for adults when administered oral or rectally or is 2.4 g.

Oral, after a meal. Rheumatoid arthritis - by 0.8 g 3 times a day in osteoarthrosis and ankylosing spondylitis - by 0.4-0.6 g 3-4 times a day, in juvenile rheumatoid arthritis - at 30-40 mg / kg / day in several stages.

When soft tissue injuries, sprains - 1.6-2.4 g / day in divided doses.

At moderate pain syndrome - 1.2 g per day.

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Ibuprofen side effects

Digestive system: frequently - nausea, anorexia, vomiting, epigastric discomfort, diarrhea, possibly the development of erosive and ulcerative lesions of the gastrointestinal tract; rare - bleeding from the gastrointestinal tract, long-term use possible liver problems.

Central nervous system and peripheral nervous systems: frequently - headache, dizziness, sleep disturbances, agitation, visual impairment.

Hemopoietic system: long-term use may be anemia, thrombocytopenia, agranulocytosis.

Urinary tract: long-term use possible renal dysfunction.

Allergic reactions: often - skin rash, Quincke's edema, rarely - aseptic meningitis, bronchospasm syndrome.

Local reactions: when topical used may be hyperemia of the skin, burning or tingling.

Contraindications

Erosive-ulcerative lesions in the gastrointestinal tract exacerbation, diseases of the optic nerve, "aspirin triad", hemodyscrasia, pronounced renal dysfunction and / or liver, children age (to 6 years), hypersensitivity to Ibuprofen.

Using during pregnancy and breastfeeding

Do not use Ibuprofen in the III trimester of pregnancy. Application I and II trimesters of pregnancy is justified only in cases where the expected benefit to the mother than the possible harm to the fetus.

This medication Ibuprofen in small amounts excreted in breast milk. Possible using in lactation for pain and fever. If necessary, prolonged use or use in high doses, should decide on the termination of breastfeeding.

Special instructions

Precautions are used with the attendant liver and kidney diseases, chronic heart failure, with dyspeptic symptoms before treatment, immediately after surgery, with indications of a history of gastrointestinal bleeding in diseases of the digestive tract, allergic reactions associated with NSAID intake.

In the course of treatment requires systematic monitoring of the liver and kidneys, peripheral blood picture.

It should not be applied externally to the damaged skin.

Ibuprofen drug interactions

With simultaneous use of Ibuprofen reduces the effect of antihypertensive agents, diuretics (furosemide, hypothiazide).

With the simultaneous use of anticoagulants may enhance their action.

With simultaneous application of SCS increases the risk of side effects from the gastrointestinal tract.

With the simultaneous application of Ibuprofen may displace from compounds with plasma proteins indirect anticoagulants (acenocoumarol), derivatives of hydantoin (phenytoin), oral hypoglycemic drugs sulfonylurea derivatives.

With the simultaneous use of amlodipine may be a slight reduction of antihypertensive action of amlodipine, with acetylsalicylic acid - decreased concentration of Ibuprofen in blood plasma, with baclofen - described a case of toxic gain of baclofen.

When applied simultaneously with warfarin may increase bleeding time, were also observed microhematuria, bruises with hydrochlorothiazide - perhaps a slight reduction of antihypertensive action of hydrochlorothiazide, captopril - may reduce antihypertensive effect of captopril, with cholestyramine - moderately decrease absorption of Ibuprofen.

With simultaneous application of lithium carbonate increased the concentration of lithium in blood plasma.

With simultaneous application of magnesium hydroxide increases the initial absorption of Ibuprofen, with methotrexate - increases the toxicity of methotrexate.

Ibuprofen in case of emergency / overdose

In case of overdose, call your local poison control center or emergency services.

Symptoms of overdose may include: dizziness; fast eye movements that you cannot control; slow breathing or short periods of time without breathing; blue color around the lips, mouth, and nose.

Storage conditions

In a dry, protected from light place, at temperatures below 25°C.Common expiration date for Ibuprofen tablets: 3 years.

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Ibuprofen pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Ibuprofen available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Advil 200 mg caplet0.15 USD
Advil 200 mg gel caplet0.15 USD
Advil 200 mg liqui-gel capsule0.19 USD
Advil 200 mg tablet0.15 USD
Advil allergy sinus caplet0.5 USD
Advil cold & sinus caplet0.22 USD
Advil migraine 200 mg capsule0.2 USD
Advil pm caplet0.22 USD
Apo-Ibuprofen 300 mg Tablet0.07 USD
Apo-Ibuprofen 400 mg Tablet0.08 USD
Apo-Ibuprofen 600 mg Tablet0.14 USD
CVS Pharmacy ibuprofen 200 mg caplet0.02 USD
CVS Pharmacy ibuprofen 200 mg tablet0.05 USD
CVS Pharmacy ibuprofen jr str 100 mg tablet0.14 USD
CVS Pharmacy infant ibuprofen susp drop0.25 USD
Caldolor 400 mg/4 ml vial2.21 USD
Caldolor 800 mg/8 ml vial1.58 USD
Caplets; Oral; Ibuprofen 200 mg
Capsules; Oral; Ibuprofen 200 mg
Child ibuprofen susp0.05 USD
Children's medi-profen susp0.05 USD
Children's motrin cold0.04 USD
Children's motrin cold suspension0.05 USD
Childs ibuprofen susp drp0.33 USD
Dragee; Oral; Ibuprofen 200 mg
Eck ibuprofen jr caplet0.17 USD
Eql ibuprofen 200 mg tablet0.1 USD
Gel; Topical; Ibuprofen 5%
I-prin 200 mg tablet0.05 USD
Ibu-drops 40 mg/ml suspension drops0.42 USD
Ibuprofen 100 mg tablet chew0.15 USD
Ibuprofen 100 mg/5ml Suspension0.06 USD
Ibuprofen 200 mg caplet0.06 USD
Ibuprofen 200 mg tablet0.03 USD
Ibuprofen 400 mg tablet0.35 USD
Ibuprofen 600 mg tablet0.33 USD
Ibuprofen 800 mg tablet0.36 USD
Ibuprofen cold suspension0.05 USD
Ibuprofen cold-sinus caplet0.2 USD
Ibuprofen ib 200 mg tablet0.08 USD
Ibuprofen pm caplet0.17 USD
Ibuprofen powder1.04 USD
Infant ibuprofen susp drop0.29 USD
Infant's motrin 50 mg/1.25 ml0.34 USD
Infants medi-profen susp0.23 USD
Medi-profen 200 mg tablet0.07 USD
Midol caplet0.21 USD
Motrin 100 mg caplet0.2 USD
Motrin 100 mg tablet chew0.18 USD
Motrin 400 mg tablet0.29 USD
Motrin 600 mg tablet0.4 USD
Motrin 800 mg tablet0.59 USD
Motrin ib 200 mg caplet0.15 USD
Motrin ib 200 mg gelcap0.12 USD
Motrin ib 200 mg tablet0.13 USD
Motrin pm caplet0.2 USD
Neoprofen 20 mg/2 ml vial304.5 USD
Novo-Profen 400 mg Tablet0.08 USD
Novo-Profen 600 mg Tablet0.05 USD
Nu-Ibuprofen 600 mg Tablet0.14 USD
Nuprin 200 mg caplet0.12 USD
Nuprin 200 mg tablet0.1 USD
Nuprin arthritis patch1.11 USD
Nuprin muscle & joint patch1.03 USD
Ointment; Topical; Ibuprofen 5%
Profen II 45-800 mg 12 Hour tablet0.69 USD
Pub infants profenib drops0.18 USD
Pv ibuprofen 200 mg caplet0.04 USD
Pv ibuprofen 200 mg tablet0.02 USD
Sm ibuprofen ib 100 mg tablet0.18 USD
Soba children's profenib susp0.04 USD
Soba profen cold-sinus tablet0.22 USD
Soba profen ib caplet0.19 USD
Suppositories; Rectal; Ibuprofen 500 mg
Suppositories; Rectal; Ibuprofen 600 mg
Suspension; Oral; Ibuprofen 100 mg / 5 ml
Suspension; Oral; Ibuprofen 40 mg / ml
Tablets, Chewable; Oral; Ibuprofen 100 mg
Tablets, Chewable; Oral; Ibuprofen 50 mg
Tablets, Effervescent; Oral; Ibuprofen 200 mg
Tablets, Film-Coated; Oral; Ibuprofen
Tablets, Film-Coated; Oral; Ibuprofen 200 mg
Tablets, Film-Coated; Oral; Ibuprofen 400 mg
Tablets, Film-Coated; Oral; Ibuprofen 600 mg
Tablets, Retard; Oral; Ibuprofen 800 mg
Tablets, Sugar-Coated; Oral; Ibuprofen 100 mg
Tablets; Oral; Ibuprofen 100 mg
Tablets; Oral; Ibuprofen 200 mg
Tablets; Oral; Ibuprofen 300 mg
Tablets; Oral; Ibuprofen 400 mg
Tablets; Oral; Ibuprofen 600 mg
Tablets; Oral; Ibuprofen 800 mg
Wal-profen 200 mg caplet0.12 USD
Wal-profen 200 mg tablet0.12 USD
Wal-profen cold & sinus cplt0.3 USD

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Ibuprofen destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Ibuprofen Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Ibuprofen pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."IBUPROFEN TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."IBUPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "ibuprofen". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Ibuprofen?

Depending on the reaction of the Ibuprofen after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ibuprofen not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Ibuprofen addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Ibuprofen, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ibuprofen consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Ibuprofen useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sDrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Useful1
100.0%

Three visitors reported side effects

Did you get side effects while taking the Ibuprofen drug, or were there no side effects?
According to the survey conducted by website sDrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Ibuprofen medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
Visitors%
No side effects2
66.7%
It has side effects1
33.3%

Four visitors reported price estimates

What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
The report given by the sDrugs.com website users shows the following figures about several people who felt the medicine Ibuprofen is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
Visitors%
Not expensive3
75.0%
Expensive1
25.0%

Four visitors reported frequency of use

How often in a day do you take the medicine?
Are you taking the Ibuprofen drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Ibuprofen is mentioned below.
Visitors%
Once in a day3
75.0%
4 times in a day1
25.0%

Four visitors reported doses

What is the dose of Ibuprofen drug you are taking?
According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 101-200mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
101-200mg3
75.0%
201-500mg1
25.0%

Two visitors reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Ibuprofen drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors%
After food2
100.0%

Five visitors reported age

Visitors%
30-453
60.0%
16-292
40.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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