DRUGS & SUPPLEMENTS
What do you feel about the cost of the medicine? Is it expensive?
Himox-LS is an antibiotic of group semisynthetic penicillins a wide spectrum of action. It is a 4-hydroxyl analog of ampicillin. It has bactericidal action. Himox-LS (Amoxicillin) is active against aerobic gram-positive bacteria: Staphylococcus spp. (except strains producing penicillinase), Streptococcus spp; aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella spp., Salmonella spp., Klebsiella spp.
Microorganisms producing penicillinase is resistant to Himox-LS (Amoxicillin).
In combination with metronidazole Himox-LS (Amoxicillin) is active against Helicobacter Pylori. It is believed that inhibits the development of Himox-LS (Amoxicillin) resistance of Helicobacter pylori to metronidazole.
There is a cross-resistance between amoxycillin and ampicillin.
The spectrum of antibacterial action while expanding the application of Himox-LS (Amoxicillin) and beta-lactamase inhibitor clavulanic acid. This combination increased the activity of Himox-LS (Amoxicillin) against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) Pseudomallei. However, Pseudomonas Aeruginosa, Serratia Marcescens, and many other gram-bacteria are resistant.
When Himox-LS (Amoxicillin) administered orally Himox-LS (Amoxicillin) rapidly and completely absorbed from the gastrointestinal tract and is not destroyed in the acidic environment of the stomach. Cmax of Himox-LS (Amoxicillin) in the blood plasma is reached after 1-2 h. When increasing doses of 2 times the concentration also increased by 2 times. In the presence of food in the stomach does not reduce the overall removals. Similar concentrations of Himox-LS (Amoxicillin) reached in the blood when administered orally, IV and IM.
The binding of Himox-LS (Amoxicillin) to plasma proteins is about 20%.
Widely distributed in tissues and body fluids. Reported high concentrations of Himox-LS (Amoxicillin) in the liver.
T1/2 from the plasma is 1-1.5 h. About 60% of the dose adopted by mouth, is excreted unchanged in the urine by glomerular filtration and tubular secretion, with a dose of 250 mg of Himox-LS (Amoxicillin) concentration in urine exceeds 300 micrograms / ml. A number of Himox-LS (Amoxicillin) is determined in feces.
T1/2 for Newborns and the elderly can be longer.
In renal insufficiency T1/2 may be 7-20 hours.
In small quantities Himox-LS (Amoxicillin) penetrates through BBB in inflammation of the pia mater.
Himox-LS (Amoxicillin) is removed by hemodialysis.
For use Himox-LS (Amoxicillin) as monotherapy and in combination with clavulanic acid: an infectious-inflammatory diseases caused by susceptible microorganisms, including bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, infections of the gastrointestinal tract, gynecological infections, infections of the skin and soft tissue, listeria, leptospirosis, gonorrhea.
For use Himox-LS (Amoxicillin) in combination with metronidazole: chronic gastritis in acute, peptic ulcer and duodenal ulcer in acute, associated with Helicobacter Pylori.
Individual. For oral single dose for adults and children over 10 years is 250-500 mg, in case of serious illness - up to 1 g. For children aged 5-10 years, a single dose of 250 mg in age from 2 to 5 years - 125 mg for children aged under 2 years of daily dose is 20 mg / kg. For adults and children interval is 8 h. In the treatment of acute uncomplicated gonorrhea - 3 g once (in combination with probenecid). Patients with impaired renal function in creatinine clearance 10-40 ml / min interval between doses should be increased to 12 h and if creatinine clearance is less than 10 ml / min interval between doses should be 24 hours.
When parenteral use in adults IM - 1 g 2 times / day, IV (with normal renal function) - 2.12 g / day. Children IM 50 mg / kg / day, single dose - 500 mg, the frequency of administration - 2 times / day; IV - 100-200 mg / kg / day. Patients with impaired renal function the dose and the interval between the injections need to be adjusted in accordance with the values of creatinine clearance.
Allergic reactions: urticaria, erythema, edema Quincke, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, in rare cases - anaphylactic shock.
Side effects associated with chemotherapy effect: possible development of super-infection (particularly in patients with chronic diseases or low resistance of the organism).
With prolonged use at high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, seizures.
Mostly when Himox-LS (Amoxicillin) used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, a violation of hematopoiesis.
Mostly when Himox-LS (Amoxicillin) used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.
Infectious mononucleosis, lymphatic leukemia, severe gastrointestinal infections, accompanied by diarrhea or vomiting, respiratory viral infection, allergic diathesis, bronchial asthma, hay fever, sensitivity to penicillin and / or cephalosporins.
For use in combination with metronidazole: diseases of the nervous system; hemodyscrasia, lymphocytic leukemia, an infectious mononucleosis; Hypersensitivity to nitroimidazole derivatives.
For use in combination with clavulanic acid: a history of instructions for liver problems and jaundice, associated with the reception of Himox-LS in combination with clavulanic acid.
Himox-LS (Amoxicillin) crosses the placenta, in small amounts excreted in breast milk.
If necessary the use of Himox-LS (Amoxicillin) during pregnancy should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus.
With careful use Himox-LS (Amoxicillin) during lactation (breastfeeding).
With caution used in patients prone to allergic reactions.
Himox-LS in combination with metronidazole is not recommended to use in patients younger than 18 years should not be used for liver diseases.
In the combined therapy with metronidazole is recommended not to drink alcohol.
Treatment must continue 48-72 hours after the disappearance of clinical signs of disease, with streptococcal infections - 10 days.
During the course treatment is necessary to control the state functions of hematopoiesis, liver and kidneys.
Perhaps the development of superinfection due to growth insensitive to the drug microflora. In the case of superinfection requires removal of Himox-LS (Amoxicillin) and the corresponding change in antibiotic therapy. When treating patients with bacteremia may develop bacteriolysis reaction (reaction of Jarisch-Herxheimer).
Patients who have an increased sensitivity to penicillin, may be cross-allergic reactions to cephalosporin antibiotics.
In the treatment of mild diarrhea at the background of the treatment should be avoided antidiarrhoeal drugs that reduce intestinal motility; can use kaolin or attapulgite containing antidiarrhoeal stuff. Patients with severe diarrhea should consult a doctor.
With simultaneous use of Himox-LS (Amoxicillin) and oral contraceptives estrogensoderzhaschih and Himox-LS (Amoxicillin) should if possible to use additional methods of contraception.
Himox-LS (Amoxicillin) may decrease the effectiveness of contraceptives for oral administration.
With the simultaneous use of Himox-LS (Amoxicillin) with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) appears synergies; with bacteriostatic antibiotic (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulphonamide) - antagonism.
Himox-LS (Amoxicillin) increases the effects of indirect anticoagulants inhibiting intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Himox-LS (Amoxicillin) reduces the effect of drugs, in the process of metabolism that produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of Himox-LS (Amoxicillin), which can be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides, slow down and reduce, and ascorbic acid increases the absorption of Himox-LS (Amoxicillin).
With the combined use of Himox-LS (Amoxicillin) and clavulanic acid pharmacokinetics of both components unchanged.
Symptoms: nausea, vomiting, diarrhea, disruption of water and electrolyte balance (as a result of vomiting and diarrhea); for prolonged use at high doses - neurotoxic reactions and thrombocytopenia (these phenomena are reversible and disappear after drug withdrawal).
Treatment: gastric lavage, the prescription of activated charcoal, saline laxatives, correction of water and electrolyte balance; hemodialysis.
NADA 055-058, Approved by FDA
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Himox-LS (Cloxacillin) (cloxacillin benzathine) for Intramammary Infusion into the Dry Cow is a product which provides bactericidal activity against gram-positive bacteria. The active agent, Himox-LS (Cloxacillin) benzathine, is a sparingly soluble salt of the semisynthetic penicillin, Himox-LS (Cloxacillin). Himox-LS (Cloxacillin) is a derivative of 6-aminopenicillanic acid, and therefore is chemically related to other penicillins. It has, however, the antibacterial properties described below, which distinguish it from certain other penicillins.
Each 10 mL disposable syringe contains Himox-LS (Cloxacillin) benzathine equivalent to 500 mg of Himox-LS (Cloxacillin) activity in a stable peanut oil gel. This product was manufactured by a non-sterilizing process.
Do not store above 25°C (77°F). Do not freeze.
In the non-lactating mammary gland, Himox-LS (Cloxacillin) (cloxacillin benzathine) provides bactericidal levels of the active antibiotic, Himox-LS (Cloxacillin), for a prolonged period of time. This prolonged activity is due to the low solubility of the Himox-LS (Cloxacillin) benzathine and to the slow-release oil-gel base. This prolonged contact between the antibiotic and the pathogenic organism enhances the probability of a bacteriological cure.
Himox-LS (Cloxacillin) is not destroyed by the enzyme, penicillinase, and therefore, is active against penicillin-resistant strains of Staphylococcus aureus. It is also active against non-penicillinase-producing Staphylococcus aureus as well as Streptococcus agalactiae.
The class disc, Methicillin 5 mcg, should be used to estimate the in vitro susceptibility of bacteria to Himox-LS (Cloxacillin).
For the treatment of mastitis in dairy cows during the dry period.
Himox-LS (Cloxacillin) has been shown by extensive clinical studies to be efficacious in the treatment of mastitis in dry cows, when caused by Streptococcus agalactiae and Staphylococcus aureus including penicillin-resistant strains.
Treatment of the dry cow with Himox-LS (Cloxacillin) is indicated in any cow known to harbor any of these organisms in the udder at drying off, or which has had repeated attacks of mastitis during the previous lactation, or is affected with mastitis at drying off, if caused by susceptible organisms.
Infuse the contents of one syringe (10 mL) into each quarter following the last milking. See Directions for Use.
Himox-LS (Cloxacillin) (cloxacillin benzathine) is for use in dry cows only. Administer immediately after the last milking. Use no later than 30 days prior to calving.
Completely milk out all four quarters. The udder and teats should be thoroughly washed with warm water containing a suitable dairy antiseptic and dried, preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol, using a separate swab for each teat. Allow to dry.
Himox-LS (Cloxacillin) is packaged with the Opti-Sert® Protective Cap.
For partial insertion: Twist off upper portion of the Opti-Sert Protective Cap to expose 3–4 mm of the syringe tip.
For full insertion: Remove protective cap to expose the full length of the syringe tip.
Insert syringe tip into the teat canal and expel the entire contents of syringe into the quarter. Withdraw the syringe and gently massage the quarter to distribute the medication.
Do not infuse contents of the mastitis syringe into the teat canal if the Opti-Sert Protective Cap is broken or damaged.
Because it is a derivative of 6-aminopenicillanic acid, Himox-LS (Cloxacillin) has the potential for producing allergic reactions. Such reactions are rare; however, should they occur, the subject should be treated with antihistamines or pressor amines, such as epinephrine.
1. For use in dry cows only.
2. Not to be used within 30 days of calving.
3. Any animal infused with this product must not be slaughtered for food until 30 days after the latest infusion.
Himox-LS (Cloxacillin) (cloxacillin benzathine) Intramammary Infusion is supplied as 10 mL syringes containing 500 mg of Himox-LS (Cloxacillin) activity per syringe. One display carton contains 12 syringes. One pail contains 144 syringes.
NDC 0010-4720-01 - 10 mL syringe
NDC 0010-4720-02 - 12 syringes
NDC 0010-4720-03 - 144 syringes
Opti-Sert is a registered trademark of Zoetis W LLC - used under license.
Himox-LS (Cloxacillin) is a registered trademark of Boehringer Ingelheim Vetmedica, Inc.
© 2014 Boehringer Ingelheim Vetmedica, Inc. All Rights Reserved.
Made in Italy
Boehringer Ingelheim Vetmedica, Inc.
St. Joseph, MO 64506 U.S.A.
Depending on the reaction of the Himox-LS after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Himox-LS not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Himox-LS addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
There are no reviews yet. Be the first to write one!
The information was verified by Dr. Rachana Salvi, MD Pharmacology