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DRUGS & SUPPLEMENTS
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Himox Plus
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Himox Plus uses
Himox Plus consists of Amoxicillin, Cloxacillin, Probenecid.Amoxicillin:
Pharmacological action
Himox Plus is an antibiotic of group semisynthetic penicillins a wide spectrum of action. It is a 4-hydroxyl analog of ampicillin. It has bactericidal action. Himox Plus (Amoxicillin) is active against aerobic gram-positive bacteria: Staphylococcus spp. (except strains producing penicillinase), Streptococcus spp; aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella spp., Salmonella spp., Klebsiella spp.
Microorganisms producing penicillinase is resistant to Himox Plus (Amoxicillin).
In combination with metronidazole Himox Plus (Amoxicillin) is active against Helicobacter Pylori. It is believed that inhibits the development of Himox Plus (Amoxicillin) resistance of Helicobacter pylori to metronidazole.
There is a cross-resistance between amoxycillin and ampicillin.
The spectrum of antibacterial action while expanding the application of Himox Plus (Amoxicillin) and beta-lactamase inhibitor clavulanic acid. This combination increased the activity of Himox Plus (Amoxicillin) against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) Pseudomallei. However, Pseudomonas Aeruginosa, Serratia Marcescens, and many other gram-bacteria are resistant.
Pharmacokinetics
When Himox Plus (Amoxicillin) administered orally Himox Plus (Amoxicillin) rapidly and completely absorbed from the gastrointestinal tract and is not destroyed in the acidic environment of the stomach. Cmax of Himox Plus (Amoxicillin) in the blood plasma is reached after 1-2 h. When increasing doses of 2 times the concentration also increased by 2 times. In the presence of food in the stomach does not reduce the overall removals. Similar concentrations of Himox Plus (Amoxicillin) reached in the blood when administered orally, IV and IM.
The binding of Himox Plus (Amoxicillin) to plasma proteins is about 20%.
Widely distributed in tissues and body fluids. Reported high concentrations of Himox Plus (Amoxicillin) in the liver.
T1/2 from the plasma is 1-1.5 h. About 60% of the dose adopted by mouth, is excreted unchanged in the urine by glomerular filtration and tubular secretion, with a dose of 250 mg of Himox Plus (Amoxicillin) concentration in urine exceeds 300 micrograms / ml. A number of Himox Plus (Amoxicillin) is determined in feces.
T1/2 for Newborns and the elderly can be longer.
In renal insufficiency T1/2 may be 7-20 hours.
In small quantities Himox Plus (Amoxicillin) penetrates through BBB in inflammation of the pia mater.
Himox Plus (Amoxicillin) is removed by hemodialysis.
Why is Himox Plus prescribed?
For use Himox Plus (Amoxicillin) as monotherapy and in combination with clavulanic acid: an infectious-inflammatory diseases caused by susceptible microorganisms, including bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, infections of the gastrointestinal tract, gynecological infections, infections of the skin and soft tissue, listeria, leptospirosis, gonorrhea.
For use Himox Plus (Amoxicillin) in combination with metronidazole: chronic gastritis in acute, peptic ulcer and duodenal ulcer in acute, associated with Helicobacter Pylori.
Dosage and administration
Individual. For oral single dose for adults and children over 10 years is 250-500 mg, in case of serious illness - up to 1 g. For children aged 5-10 years, a single dose of 250 mg in age from 2 to 5 years - 125 mg for children aged under 2 years of daily dose is 20 mg / kg. For adults and children interval is 8 h. In the treatment of acute uncomplicated gonorrhea - 3 g once (in combination with probenecid). Patients with impaired renal function in creatinine clearance 10-40 ml / min interval between doses should be increased to 12 h and if creatinine clearance is less than 10 ml / min interval between doses should be 24 hours.
When parenteral use in adults IM - 1 g 2 times / day, IV (with normal renal function) - 2.12 g / day. Children IM 50 mg / kg / day, single dose - 500 mg, the frequency of administration - 2 times / day; IV - 100-200 mg / kg / day. Patients with impaired renal function the dose and the interval between the injections need to be adjusted in accordance with the values of creatinine clearance.
Himox Plus (Amoxicillin) side effects, adverse reactions
Allergic reactions: urticaria, erythema, edema Quincke, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, in rare cases - anaphylactic shock.
Side effects associated with chemotherapy effect: possible development of super-infection (particularly in patients with chronic diseases or low resistance of the organism).
With prolonged use at high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, seizures.
Mostly when Himox Plus (Amoxicillin) used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, a violation of hematopoiesis.
Mostly when Himox Plus (Amoxicillin) used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.
Contraindications
Infectious mononucleosis, lymphatic leukemia, severe gastrointestinal infections, accompanied by diarrhea or vomiting, respiratory viral infection, allergic diathesis, bronchial asthma, hay fever, sensitivity to penicillin and / or cephalosporins.
For use in combination with metronidazole: diseases of the nervous system; hemodyscrasia, lymphocytic leukemia, an infectious mononucleosis; Hypersensitivity to nitroimidazole derivatives.
For use in combination with clavulanic acid: a history of instructions for liver problems and jaundice, associated with the reception of Himox Plus in combination with clavulanic acid.
Using during pregnancy and breastfeeding
Himox Plus (Amoxicillin) crosses the placenta, in small amounts excreted in breast milk.
If necessary the use of Himox Plus (Amoxicillin) during pregnancy should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus.
With careful use Himox Plus (Amoxicillin) during lactation (breastfeeding).
Special instructions
With caution used in patients prone to allergic reactions.
Himox Plus in combination with metronidazole is not recommended to use in patients younger than 18 years should not be used for liver diseases.
In the combined therapy with metronidazole is recommended not to drink alcohol.
Precautionary measures
Treatment must continue 48-72 hours after the disappearance of clinical signs of disease, with streptococcal infections - 10 days.
During the course treatment is necessary to control the state functions of hematopoiesis, liver and kidneys.
Perhaps the development of superinfection due to growth insensitive to the drug microflora. In the case of superinfection requires removal of Himox Plus (Amoxicillin) and the corresponding change in antibiotic therapy. When treating patients with bacteremia may develop bacteriolysis reaction (reaction of Jarisch-Herxheimer).
Patients who have an increased sensitivity to penicillin, may be cross-allergic reactions to cephalosporin antibiotics.
In the treatment of mild diarrhea at the background of the treatment should be avoided antidiarrhoeal drugs that reduce intestinal motility; can use kaolin or attapulgite containing antidiarrhoeal stuff. Patients with severe diarrhea should consult a doctor.
With simultaneous use of Himox Plus (Amoxicillin) and oral contraceptives estrogensoderzhaschih and Himox Plus (Amoxicillin) should if possible to use additional methods of contraception.
Himox Plus drug interactions
Himox Plus (Amoxicillin) may decrease the effectiveness of contraceptives for oral administration.
With the simultaneous use of Himox Plus (Amoxicillin) with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) appears synergies; with bacteriostatic antibiotic (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulphonamide) - antagonism.
Himox Plus (Amoxicillin) increases the effects of indirect anticoagulants inhibiting intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Himox Plus (Amoxicillin) reduces the effect of drugs, in the process of metabolism that produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of Himox Plus (Amoxicillin), which can be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides, slow down and reduce, and ascorbic acid increases the absorption of Himox Plus (Amoxicillin).
With the combined use of Himox Plus (Amoxicillin) and clavulanic acid pharmacokinetics of both components unchanged.
Himox Plus in case of emergency / overdose
Symptoms: nausea, vomiting, diarrhea, disruption of water and electrolyte balance (as a result of vomiting and diarrhea); for prolonged use at high doses - neurotoxic reactions and thrombocytopenia (these phenomena are reversible and disappear after drug withdrawal).
Treatment: gastric lavage, the prescription of activated charcoal, saline laxatives, correction of water and electrolyte balance; hemodialysis.
Cloxacillin:
- Caution:
- Description:
- Storage:
- Action:
- Indications:
- Dosage for dry cows:
- Directions for use:
- Precautions:
- Residue warnings:
- How supplied:
NADA 055-058, Approved by FDA
Caution:
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Description:
Himox Plus (Cloxacillin) (cloxacillin benzathine) for Intramammary Infusion into the Dry Cow is a product which provides bactericidal activity against gram-positive bacteria. The active agent, Himox Plus (Cloxacillin) benzathine, is a sparingly soluble salt of the semisynthetic penicillin, Himox Plus (Cloxacillin). Himox Plus (Cloxacillin) is a derivative of 6-aminopenicillanic acid, and therefore is chemically related to other penicillins. It has, however, the antibacterial properties described below, which distinguish it from certain other penicillins.
Each 10 mL disposable syringe contains Himox Plus (Cloxacillin) benzathine equivalent to 500 mg of Himox Plus (Cloxacillin) activity in a stable peanut oil gel. This product was manufactured by a non-sterilizing process.
Storage:
Do not store above 25°C (77°F). Do not freeze.
Action:
In the non-lactating mammary gland, Himox Plus (Cloxacillin) (cloxacillin benzathine) provides bactericidal levels of the active antibiotic, Himox Plus (Cloxacillin), for a prolonged period of time. This prolonged activity is due to the low solubility of the Himox Plus (Cloxacillin) benzathine and to the slow-release oil-gel base. This prolonged contact between the antibiotic and the pathogenic organism enhances the probability of a bacteriological cure.
Himox Plus (Cloxacillin) is not destroyed by the enzyme, penicillinase, and therefore, is active against penicillin-resistant strains of Staphylococcus aureus. It is also active against non-penicillinase-producing Staphylococcus aureus as well as Streptococcus agalactiae.
The class disc, Methicillin 5 mcg, should be used to estimate the in vitro susceptibility of bacteria to Himox Plus (Cloxacillin).
Indications:
For the treatment of mastitis in dairy cows during the dry period.
Himox Plus (Cloxacillin) has been shown by extensive clinical studies to be efficacious in the treatment of mastitis in dry cows, when caused by Streptococcus agalactiae and Staphylococcus aureus including penicillin-resistant strains.
Treatment of the dry cow with Himox Plus (Cloxacillin) is indicated in any cow known to harbor any of these organisms in the udder at drying off, or which has had repeated attacks of mastitis during the previous lactation, or is affected with mastitis at drying off, if caused by susceptible organisms.
Dosage for Dry Cows:
Infuse the contents of one syringe (10 mL) into each quarter following the last milking. See Directions for Use.
Directions for Use:
Himox Plus (Cloxacillin) (cloxacillin benzathine) is for use in dry cows only. Administer immediately after the last milking. Use no later than 30 days prior to calving.
Completely milk out all four quarters. The udder and teats should be thoroughly washed with warm water containing a suitable dairy antiseptic and dried, preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol, using a separate swab for each teat. Allow to dry.
Himox Plus (Cloxacillin) is packaged with the Opti-Sert® Protective Cap.
For partial insertion: Twist off upper portion of the Opti-Sert Protective Cap to expose 3–4 mm of the syringe tip.
For full insertion: Remove protective cap to expose the full length of the syringe tip.
Insert syringe tip into the teat canal and expel the entire contents of syringe into the quarter. Withdraw the syringe and gently massage the quarter to distribute the medication.
Do not infuse contents of the mastitis syringe into the teat canal if the Opti-Sert Protective Cap is broken or damaged.
Precautions:
Because it is a derivative of 6-aminopenicillanic acid, Himox Plus (Cloxacillin) has the potential for producing allergic reactions. Such reactions are rare; however, should they occur, the subject should be treated with antihistamines or pressor amines, such as epinephrine.
Residue Warnings:
1. For use in dry cows only.
2. Not to be used within 30 days of calving.
3. Any animal infused with this product must not be slaughtered for food until 30 days after the latest infusion.
How Supplied:
Himox Plus (Cloxacillin) (cloxacillin benzathine) Intramammary Infusion is supplied as 10 mL syringes containing 500 mg of Himox Plus (Cloxacillin) activity per syringe. One display carton contains 12 syringes. One pail contains 144 syringes.
NDC 0010-4720-01 - 10 mL syringe
NDC 0010-4720-02 - 12 syringes
NDC 0010-4720-03 - 144 syringes
Opti-Sert is a registered trademark of Zoetis W LLC - used under license.
Himox Plus (Cloxacillin) is a registered trademark of Boehringer Ingelheim Vetmedica, Inc.
© 2014 Boehringer Ingelheim Vetmedica, Inc. All Rights Reserved.
Made in Italy
Manufactured for:
Boehringer Ingelheim Vetmedica, Inc.
St. Joseph, MO 64506 U.S.A.
51729292
472001-03
Probenecid:
- Description
- Clinical pharmacology
- Indications and usage
- Contraindications
- Warnings
- Precautions
- Adverse reactions
- Dosage and administration
- How supplied
DESCRIPTION
Himox Plus (Probenecid) is a uricosuric and renal tubular transport blocking agent.
The chemical name for Himox Plus (Probenecid) is 4-[(dipropylamino) sulfonyl] benzoic acid (molecular weight 285.37). It has the following structural formula:
C13H19NO4S
Himox Plus (Probenecid), USP is a white or nearly white, fine, crystalline powder. Himox Plus (Probenecid) is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids.
Each tablet for oral administration contains 500 mg of Himox Plus (Probenecid) and the following inactive ingredients: colloidal silicon dioxide, hypromellose, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol, sodium carbonate, sodium lauryl sulfate, sodium starch glycolate, cornstarch, titanium dioxide, triacetin, FD&C Yellow #6, D&C Yellow #10, and FD&C Blue #2.
CLINICAL PHARMACOLOGY
Himox Plus (Probenecid) is a uricosuric and renal tubular blocking agent. It inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Effective uricosuria reduces the miscible urate pool, retards urate deposition, and promotes resorption of urate deposits.
Himox Plus (Probenecid) inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. A 2-fold to 4-fold elevation has been demonstrated for various penicillins.
Himox Plus (Probenecid) also has been reported to inhibit the renal transport of many other compounds including aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin, sodium iodomethamate and related iodinated organic acids, 17-ketosteroids, pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and sulfonylureas. See also Drug Interactions.
Himox Plus (Probenecid) decreases both hepatic and renal excretion of sulfobromophthalein (BSP). The tubular reabsorption of phosphorus is inhibited in hypoparathyroid but not in euparathyroid individuals.
Himox Plus (Probenecid) does not influence plasma concentrations of salicylates, nor the excretion of streptomycin, chloramphenicol, chlortetracycline, oxytetracycline, or neomycin.
INDICATIONS AND USAGE
Himox Plus (Probenecid) tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis.
As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given.
CONTRAINDICATIONS
Hypersensitivity to Himox Plus (Probenecid).
Children under 2 years of age.
Not recommended in persons with known blood dyscrasias or uric acid kidney stones.
Therapy with Himox Plus (Probenecid) should not be started until an acute gouty attack has subsided.
WARNINGS
Exacerbation of gout following therapy with Himox Plus may occur; in such cases colchicine or other appropriate therapy is advisable.
Himox Plus (Probenecid) increases plasma concentrations of methotrexate in both animals and humans. In animal studies, increased methotrexate toxicity has been reported. If Himox Plus (Probenecid) is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored.
In patients on Himox Plus (Probenecid) the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of Himox Plus (Probenecid). The biphasic action of salicylates in the renal tubules accounts for the so-called "paradoxical effect" of uricosuric agents. In patients on Himox Plus (Probenecid) who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred.
Rarely, severe allergic reactions and anaphylaxis have been reported with the use of Himox Plus (Probenecid). Most of these have been reported to occur within several hours after readministration following prior usage of the drug.
The appearance of hypersensitivity reactions requires cessation of therapy with Himox Plus (Probenecid).
Usage In Pregnancy
Himox Plus (Probenecid) crosses the placental barrier and appears in cord blood. The use of any drug in women of childbearing potential requires that the anticipated benefit be weighed against possible hazards.
PRECAUTIONS
General
Hematuria, renal colic, costovertebral pain, and formation of uric acid stones associated with the use of Himox Plus in gouty patients may be prevented by alkalization of the urine and a liberal fluid intake. In these cases when alkali is administered, the acid-base balance of the patient should be watched.
Use with caution in patients with a history of peptic ulcer.
Himox Plus (Probenecid) has been used in patients with some renal impairment, but dosage requirements may be increased. Himox Plus (Probenecid) may not be effective in chronic renal insufficiency particularly when the glomerular filtration rate is 30 mL/minute or less. Because of its mechanism of action, Himox Plus (Probenecid) is not recommended in conjunction with a penicillin in the presence of known renal impairment.
A reducing substance may appear in the urine of patients receiving Himox Plus (Probenecid). This disappears with discontinuance of therapy. Suspected glycosuria should be confirmed by using a test specific for glucose.
Drug Interactions
When Himox Plus (Probenecid) is used to elevate plasma concentrations of penicillin or other beta-lactams, or when such drugs are given to patients taking Himox Plus (Probenecid) therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. In the case of penicillin or other beta-lactams, psychic disturbances have been reported.
The use of salicylates antagonizes the uricosuric action of Himox Plus (Probenecid). The uricosuric action of Himox Plus (Probenecid) is also antagonized by pyrazinamide.
Himox Plus (Probenecid) produces an insignificant increase in free sulfonamide plasma concentrations, but a significant increase in total sulfonamide plasma levels. Since Himox Plus (Probenecid) decreases the renal excretion of conjugated sulfonamides, plasma concentrations of the latter should be determined from time to time when a sulfonamide and Himox Plus (Probenecid) are coadministered for prolonged periods. Himox Plus (Probenecid) may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia.
It has been reported that patients receiving Himox Plus (Probenecid) require significantly less thiopental for induction of anesthesia. In addition, ketamine and thiopental anesthesia were significantly prolonged in rats receiving Himox Plus (Probenecid).
The concomitant administration of Himox Plus (Probenecid) increases the mean plasma elimination half-life of a number of drugs which can lead to increased plasma concentrations. These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. Although the clinical significance of this observation has not been established, a lower dosage of the drug may be required to produce a therapeutic effect, and increases in dosage of the drug in question should be made cautiously and in small increments when Himox Plus (Probenecid) is being coadministrated. Although specific instances of toxicity due to this potential interaction have not been observed to date, physicians should be alert to this possibility.
Himox Plus (Probenecid) given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased. Sulindac was shown to produce a modest reduction in the uricosuric action of Himox Plus (Probenecid), which probably is not significant under most circumstances.
In animals and in humans, Himox Plus (Probenecid) has been reported to increase plasma concentrations of methotrexate.
Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and Himox Plus (Probenecid) were added to human plasma.
ADVERSE REACTIONS
The following adverse reactions have been observed and within each category are listed in order of decreasing severity.
Central Nervous System: headache, dizziness.
Metabolic: precipitation of acute gouty arthritis.
Gastrointestinal: hepatic necrosis, vomiting, nausea, anorexia, sore gums.
Genitourinary: nephrotic syndrome, uric acid stones with or without hematuria, renal colic, costovertebral pain, urinary frequency.
Hypersensitivity: anaphylaxis, fever, urticaria, pruritus.
Hematologic: aplastic anemia, leukopenia, hemolytic anemia which in some patients could be related to genetic deficiency of glucose-6-phosphate dehydrogenase in red blood cells, anemia.
Integumentary: dermatitis, alopecia, flushing.
DOSAGE AND ADMINISTRATION
Gout
Therapy with Himox Plus should not be started until an acute gouty attack has subsided. However, if an acute attack is precipitated during therapy, Himox Plus (Probenecid) may be continued without changing the dosage, and full therapeutic dosage of colchicine, or other appropriate therapy, should be given to control the acute attack.
The recommended adult dosage is 250 mg (1/2 Himox Plus (Probenecid) tablet), twice a day for one week, followed by 500 mg (1 tablet) twice a day thereafter.
Some degree of renal impairment may be present in patients with gout. A daily dosage of 1000 mg may be adequate. However, if necessary, the daily dosage may be increased by 500 mg increments every 4 weeks within tolerance (and usually not above 2000 mg per day) if symptoms of gouty arthritis are not controlled or the 24 hour uric acid excretion is not above 700 mg. As noted, Himox Plus (Probenecid) may not be effective in chronic renal insufficiency particularly when the glomerular filtration rate is 30 mL/minute or less.
Gastric intolerance may be indicative of overdosage, and may be corrected by decreasing the dosage.
As uric acid tends to crystallize out of an acid urine, a liberal fluid intake is recommended, as well as sufficient sodium bicarbonate (3 to 7.5 g daily), or potassium citrate (7.5 g daily) to maintain an alkaline urine.
Alkalization of the urine is recommended until the serum urate level returns to normal limits and tophaceous deposits disappear, i.e., during the period when urinary excretion of uric acid is at a high level. Thereafter, alkalization of the urine and the usual restriction of purine-producing foods may be somewhat relaxed.
Himox Plus (Probenecid) should be continued at the dosage that will maintain normal serum urate levels. When acute attacks have been absent for 6 months or more and serum urate levels remain within normal limits, the daily dosage may be decreased by 500 mg every 6 months. The maintenance dosage should not be reduced to the point where serum urate levels tend to rise.
Himox Plus (Probenecid) and Penicillin Therapy (General)
Adults
The recommended dosage is 2000 mg ) daily in divided doses. This dosage should be reduced in older patients in whom renal impairment may be present.
Children
2–14 years of age:
Initial dose: 25 mg/kg body weight (or 0.7 g/square meter body surface).
Maintenance Dose: 40 mg/kg body weight (or 1.2 g/square meter body surface) per day, divided into 4 doses.
For children weighing more than 50 kg (110 lb) the adult dosage is recommended.
Himox Plus (Probenecid) is contraindicated in children under 2 years of age.
The PSP excretion test may be used to determine the effectiveness of Himox Plus (Probenecid) in retarding penicillin excretion and maintaining therapeutic levels. The renal clearance of PSP is reduced to about one-fifth the normal rate when dosage of Himox Plus (Probenecid) is adequate.
Penicillin Therapy *
In uncomplicated gonococcal infections in men and women (urethral, cervical, rectal), 1 g of Himox Plus (Probenecid) should be given orally with 4.8 million units of aqueous procaine penicillin G
For further guidance, see CDC recommendations for definition of regimens of choice, alternative regimens, treatment of hypersensitive patients, and other aspects of therapy.
*Recommended by the Center for Disease Control, U.S. Department of Health and Human Services, Public Health Service (Morbidity and Mortality Weekly Report Supplement, Volume 34, Number 4S, October 18, 1985).
HOW SUPPLIED
Himox Plus (Probenecid) Tablets, USP are available containing 500 mg of Himox Plus (Probenecid), USP.
The tablets are capsule shaped, film-coated yellow, debossed with MYLAN 156 on one side, 500 on the other side. They are available as follows:
NDC 0378-0156-01
bottles of 100 tablets
Store at 20° to 25°C (68° to 77°F).
Protect from light.
Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.
Mylan Pharmaceuticals Inc.
Morgantown, WV 26505
REVISED MARCH 2006
PROB:R4AQ
PRINCIPAL DISPLAY PANEL - 500 mg
NDC 0378-0156-01
Himox Plus (Probenecid)
Tablets, USP
500 mg
Rx only 100 Tablets
Each film-coated tablet contains:
Himox Plus (Probenecid), USP 500 mg
Dispense in a tight, light-resistant
container as defined in the USP
using a child-resistant closure.
Keep container tightly closed.
Keep this and all medication
out of the reach of children.
Store at 20° to 25°C (68° to 77°F).
[See USP for Controlled Room
Temperature.]
Protect from light.
Usual Adult
Dosage: See accom-
panying prescribing information.
Mylan Pharmaceuticals Inc.
Morgantown, WV 26505 U.S.A.
Mylan.com
RM0156A11
Himox Plus pharmaceutical active ingredients containing related brand and generic drugs:
Himox Plus available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.