DRUGS & SUPPLEMENTS

Heparin

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Heparin uses


Unfractionated Heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight Heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated Heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.

Indication: Unfractionated Heparin is indicated for prophylaxis and treatment of venous thrombosis and its extension, prevention of post-operative deep venous thrombosis and pulmonary embolism and prevention of clotting in arterial and cardiac surgery. In cardiology, it is used to prevent embolisms in patients with atrial fibrillation and as an adjunct antithrombin therapy in patients with unstable angina and/or non-Q wave myocardial infarctions (i.e. non-ST elevated acute coronary artery syndrome) who are on platelet glycoprotein (IIb/IIIa) receptor inhibitors. Additionally, it is used to prevent clotting during dialysis and surgical procedures, maintain the patency of intravenous injection devices and prevent in vitro coagulation of blood transfusions and in blood samples drawn for laboratory values.

Unfractionated Heparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from 3000 to 30,000 daltons. Heparin is obtained from liver, lung, mast cells, and other cells of vertebrates. Heparin is a well-known and commonly used anticoagulant which has antithrombotic properties. Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Small amounts of Heparin in combination with antithrombin III, a Heparin cofactor,) can inhibit thrombosis by inactivating Factor Xa and thrombin. Once active thrombosis has developed, larger amounts of Heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor. Heparin prolongs several coagulation tests. Of all the coagulation tests, activated partial prothrombin time (aPTT) is the most clinically important value.

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Heparin pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Heparin available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Hep-lock flush 10 unit/ml kit8.91 USD
Hep-lock flush 100 unit/ml kit10.08 USD
Hep-lock u-p 10 unit/ml vial0.98 USD
Hep-lock u-p 100 unit/ml vial0.96 USD
Hepalean 1000 unit/ml0.98 USD
Hepalean 10000 unit/ml2.32 USD
Heparin Leo 100 unit/ml Lock Flush0.36 USD
Heparin Leo 1000 unit/ml0.43 USD
Heparin Leo 10000 unit/ml2.03 USD
Heparin Leo 25000 unit/ml8.42 USD
Heparin Lock Flush 10 unit/ml Lock Flush0.29 USD
Heparin Lock Flush 100 unit/ml Lock Flush0.3 USD
Heparin Sodium (Porcine) 1000 unit/ml Solution 10ml Vial188.99 USD
Heparin Sodium (Porcine) 10000 unit/ml Solution 5ml Vial29.99 USD
Heparin Sodium (Porcine) 10000 unit/ml vial10.37 USD
Heparin iv flush 1 unit/ml syr0.19 USD
Heparin iv flush 100 unit/ml2.71 USD
Heparin iv flush 2 unit/ml syr0.19 USD
Heparin lock 10 unit/ml vial0.1 USD
Heparin lock 100 unit/ml vial0.13 USD
Heparin lock flush 10 unit/ml1.21 USD
Heparin lock flush 100 unit/ml1.13 USD
Heparin sod 1000 unit/ml vial7.92 USD
Heparin sod 100000 unit powder256.73 USD
Heparin sod 1000000 unit powder1318.63 USD
Heparin sod 25000 unit powder58.8 USD
Heparin sod 5000 unit/ml syringe3.08 USD
Heparin-1/2ns 12500 unit/2500.02 USD
Heparin-1/2ns 25000 unit/2500.03 USD
Heparin-ns 2000 unit/1000 ml0.01 USD
Injectable; Injection; Heparin Sodium 10 units / ml
Injectable; Injection; Heparin Sodium 10,000 IU / ml
Injectable; Injection; Heparin Sodium 10,000 units / 0.5 ml
Injectable; Injection; Heparin Sodium 10,000 units / ml
Injectable; Injection; Heparin Sodium 100 IU / ml
Injectable; Injection; Heparin Sodium 100 units / ml
Injectable; Injection; Heparin Sodium 1000 IU / ml
Injectable; Injection; Heparin Sodium 1000 units / ml
Injectable; Injection; Heparin Sodium 15,000 units / ml
Injectable; Injection; Heparin Sodium 2 units / ml
Injectable; Injection; Heparin Sodium 2,500 units / ml
Injectable; Injection; Heparin Sodium 20,000 IU / ml
Injectable; Injection; Heparin Sodium 20,000 units / m
Injectable; Injection; Heparin Sodium 20,000 units / ml
Injectable; Injection; Heparin Sodium 200 IU / ml
Injectable; Injection; Heparin Sodium 25,000 units / ml
Injectable; Injection; Heparin Sodium 2500 units / ml
Injectable; Injection; Heparin Sodium 3000 units / ml
Injectable; Injection; Heparin Sodium 40,000 units / ml
Injectable; Injection; Heparin Sodium 4000 units / ml
Injectable; Injection; Heparin Sodium 50 IU / ml
Injectable; Injection; Heparin Sodium 5000 IU / ml
Injectable; Injection; Heparin Sodium 5000 units / 0.5 ml
Injectable; Injection; Heparin Sodium 5000 units / ml
Injectable; Injection; Heparin Sodium 6000 units / ml
Injectable; Injection; Heparin Sodium 7,500 units / ml
Injectable; Injection; Heparin Sodium 7500 units / ml
Ointment; Topical; Heparin Sodium

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Heparin destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Heparin Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Heparin pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."HEPARIN SODIUM INJECTION [SAGENT PHARMACEUTICALS]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "heparin". https://pubchem.ncbi.nlm.nih.gov/su... (accessed August 28, 2018).
  3. "Heparin - DrugBank". http://www.drugbank.ca/drugs/DB0110... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Heparin?

Depending on the reaction of the Heparin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Heparin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Heparin addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Heparin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Heparin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported doses

What is the dose of Heparin drug you are taking?
According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 501mg-1g. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
501mg-1g1
100.0%

One visitor reported time for results

What is the time duration Heparin drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sDrugs.com website users needed 1 week to notice the result from using Heparin drug. The time needed to show improvement in health condition after using the medicine Heparin need not be same for all the users. It varies based on other factors.
Visitors%
1 week1
100.0%

One visitor reported age

Visitors%
> 601
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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