DRUGS & SUPPLEMENTS

Gestorin

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Gestorin uses


Pharmacological action

Gestorin is a progestogen. This medication causes a transition in the endometrium of proliferative phase, called follicular hormone in the secretory phase, and after fertilization promotes its transition to a state necessary for the development of a fertilized egg. Progesterone reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal elements of the breast. It has no androgenic activity. This drug has little effect on protein metabolism, promotes fat deposit and accumulation of glucose in the liver and reduces the reabsorption of sodium in renal tubules.

Gestorin has a blocking effect on the secretion of hypothalamic factors LH and FSH release, inhibits the formation of the pituitary gonadotropin-releasing hormone and inhibits ovulation.

Pharmacokinetics

After IM injection Gestorin is absorbed rapidly and almost completely. This medication metabolized in the liver, the majority of metabolites formed conjugates with glucuronic and sulfuric acids. T1/2 from plasma is a few minutes. This medicine is excreted in the urine - 50-60%, in feces - more than 10%. The number of metabolites which are excreted in the urine varies, depending on the phase of the corpus luteum.

Why is Gestorin prescribed?

Capsules Oral - premenstrual syndrome, fibrocystic breast disease, premenopausal, menopause, including premature, postmenopausal women - as the progestogen component of hormone replacement therapy in combination with estrogen; Capsules Vaginal - HRT when dormant in the absence of ovarian progesterone (egg donation), support the luteal phase in preparation for in vitro fertilization, support the luteal phase in spontaneous or induced menstrual cycle, prevention of habitual abortion by threatening and progestogen deficiency, endocrine infertility, prevention of uterine fibroids, endometriosis.

Solution in oil: amenorrhea, oligomenorrhea, algomenorrhea (on the basis of hypogenitalism), anovulatory metrorrhagia, infertility, endocrine (including failure of the corpus luteum), the threat of termination of pregnancy, diagnosis of estrogen.

Gel for external use: mammalgia, disease of the breast.

Dysfunctional uterine bleeding, metrorrhagia, amenorrhea, recurrent miscarriage.

Contraception.

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Dosage and administration

Orally, intravaginally, IM, locally. The dosing regimen is individual. The dose, frequency and duration of treatment with Gestorin are determined according to the scheme depending on the indications and the clinical situation.

Gestorin side effects, adverse reactions

Cardiovascular system: increased blood pressure.

Metabolic: edema.

Digestive system: liver problems, jaundice, rarely - nausea, vomiting.

Endocrine: rare (with prolonged use) - decreased libido, weight gain, pain and tension in the breasts, irregular uterine bleeding.

CNS: rare (with prolonged use) - headache, depression.

Gestorin contraindications

Severe liver or kidney problems, hepatitis, thromboembolic disease, vaginal bleeding of not established genesis, breast carcinoma (except for cases in which progesterone is used in a combination therapy of this disease).

Using during pregnancy and breastfeeding

In cases of extreme necessity Gestorin may be used during pregnancy in the established failure of the corpus luteum hormone.

Progesterone is not used in women planning a pregnancy in the near future.

Special instructions

Gestorin is used with caution in patients with cardiovascular disease, impaired liver or kidney problems, diabetes, asthma, epilepsy, migraine, depression.

Gestorin drug interactions

Gestorin reduces the intensity of the drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropin-releasing hormone of the anterior pituitary.

This medication reduces the lactogenic effect of oxytocin.

Progesterone enhances the action of diuretics, antihypertensive drugs, immunosuppressive drugs. Simultaneous administration of Gestorin with barbiturates it is marked decrease of progesterone effects.

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Gestorin pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Gestorin available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Gestorin destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Gestorin Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Gestorin pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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Frequently asked Questions

Can i drive or operate heavy machine after consuming Gestorin?

Depending on the reaction of the Gestorin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Gestorin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Gestorin addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Gestorin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Gestorin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Gestorin drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Gestorin is mentioned below.
Visitors%
Once in a day1
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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