Fluxin-AL

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Fluxin-AL uses

Fluxin-AL consists of Alprazolam, Fluoxetine Hydrochloride.

Alprazolam:


Pharmacological action

Fluxin-AL is an anxiolytic drug (tranquilizer), a derivative of triazolo-benzodiazepine. This medication has anxiolytic, sedative, hypnotic, anticonvulsant, central muscle relaxant effect. The mechanism of action is to enhance the inhibitory effect of endogenous GABA in the CNS by increasing the sensitivity of the GABA-receptor mediator as a result of stimulation of benzodiazepine receptors located in the allosteric center of postsynaptic GABA-receptor activating ascending reticular formation of brain stem neurons and the lateral horns of the spinal cord; reduces the excitability of the subcortical brain structures (the limbic system, thalamus, hypothalamus), inhibits the polysynaptic spinal reflexes.

Pronounced anxiolytic activity (reduction of emotional tension, easing anxiety, fear, anxiety) is combined with moderate soporific effect; it shortens the period of sleep, increases sleep duration and reduces the number of nighttime awakenings. The mechanism of hypnotic action is inhibition of cell reticular formation of the brain.

Pharmacokinetics

After oral administration Fluxin-AL (Alprazolam) is rapidly and completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved within 1-2 hours. Binding to plasma proteins is 80%. This drud metabolized in the liver. T1/2 is an average of 12-15 hours. Fluxin-AL (Alprazolam) and its metabolites are mainly excreted by kidneys.

Why is Fluxin-AL prescribed?

  • anxiety, neurosis accompanied by anxiety, danger, stress, deterioration of sleep, irritability, and somatic disorders
  • mixed anxiety-depressive conditions
  • neurotic reactive depression accompanied by depressed mood, loss of interest in his surroundings, anxiety, loss of sleep, decreased appetite, and somatic disorders
  • anxiety and neurotic depression that developed on the background of systemic diseases
  • panic disorder in combination and without symptoms of phobias

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    Dosage and administration

    Individual. It is recommended to use the minimum effective dose of Fluxin-AL Aurobindo. The dose is corrected in the treatment process depending on the achieved effect and tolerability. If necessary, increase the dose should be increased gradually, first in the evening and then in the daytime reception.

    The initial dose of Fluxin-AL (Alprazolam) is 250-500 mcg 3 times / day, if necessary, it gradually increases to 4.5 mg / day.

    For elderly or debilitated patients the initial dose is 250 mcg 2-3 / day, maintenance doses - 500-750 mcg / day, if necessary, taking into account the tolerance dose can be increased.

    Cancellation or reduction of the dose of Fluxin-AL (Alprazolam) should be done gradually by reducing the daily dose of no more than 500 mcg every 3 days; sometimes can needed even more slowly cancelling.

    Fluxin-AL (Alprazolam) side effects, adverse reactions

    CNS: at the beginning of treatment (especially in elderly patients) drowsiness, fatigue, dizziness, decreased ability to concentrate, ataxia, disorientation, unsteady gait, slowing of mental and motor responses; rare - headache, euphoria, depression, tremors, memory loss, impaired coordination of movements, depressed mood, confusion, extrapyramidal dystonic reactions (involuntary movements, including for eyes), weakness, myasthenia gravis, dysarthria; in some cases - paradoxical reactions (aggressive flare, confusion, psychomotor agitation, fear, suicidal tendencies, muscle spasms, hallucinations, agitation, irritability, anxiety, insomnia).

    Digestive system: possible dry mouth or excessive salivation, heartburn, nausea, vomiting, decreased appetite, constipation or diarrhea, abnormal liver function, elevated liver transaminases and alkaline phosphatase, jaundice.

    Hematopoietic system: possible leukopenia, neutropenia, agranulocytosis (chills, pyrexia, sore throat, extreme tiredness or weakness), anemia, thrombocytopenia.

    Urinary tract: possible urinary incontinence, urinary retention, renal failure, decreased or increased libido, dysmenorrhea.

    Endocrine system: possible change in body weight, disturbances in libido, menstrual irregularities.

    Cardiovascular system: possible decrease in blood pressure, tachycardia.

    Allergic reactions: possible skin rash, itching.

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    Contraindications

    Coma, shock, myasthenia gravis, angle-closure glaucoma, acute alcohol poisoning (with the weakening of the vital functions), narcotic analgesics, hypnotics and psychotropic drugs, chronic obstructive airways disease with incipient respiratory failure, acute respiratory failure, severe depression (suicidal tendencies may occur), pregnancy (especially the I trimester), lactation, childhood and adolescence to 18 years, increased sensitivity to benzodiazepines.

    Using during pregnancy and breastfeeding

    Fluxin-AL (Alprazolam) has a toxic effect on the fetus and increases the risk of birth defects when used in the I trimester of pregnancy. The constant use during pregnancy can cause physical dependence with the development of withdrawal syndrome in the newborn. Reception at therapeutic doses in the later stages of pregnancy can cause neonatal CNS depression. Using of Fluxin-AL (Alprazolam) immediately before birth or during labor can cause neonatal respiratory depression, decreased muscle tone, hypotension, hypothermia and a weak act of sucking (sucking flaccid syndrome baby).

    It is possible to excretion of the benzodiazepines in breast milk that can cause drowsiness in the newborn and hinder feeding.

    In experimental studies have been shown that Fluxin-AL (Alprazolam) and its metabolites are excreted in breast milk.

    Special instructions

    Keep in mind that anxiety or conditions related to everyday stress usually does not require treatment with anxiolytics.

    If you experience paradoxical reactions then stop taking the drug. During the period of treatment is unacceptable to use of alcoholic drinks. With caution use Fluxin-AL for drivers of vehicles and people whose profession is associated with increased concentration.

    Fluxin-AL (Alprazolam) drug interactions

    The simultaneous use of Fluxin-AL (Alprazolam) with psychotropic, anticonvulsant medications and ethanol is observed enhancement inhibitory action Fluxin-AL (Alprazolam) on the CNS.

    The simultaneous use with blockers of histamine H2-receptor reduce the clearance of Fluxin-AL (Alprazolam) and increase the inhibitory effect of Fluxin-AL (Alprazolam) on the CNS; macrolide antibiotics reduce the clearance of Fluxin-AL (Alprazolam).

    The simultaneous use with hormonal oral contraceptives increased T1/2 of Fluxin-AL (Alprazolam).

    Simultaneous administration of Fluxin-AL (Alprazolam) with dextropropoxyphene observed a more pronounced CNS depression than in combination with other benzodiazepines, as may increase the concentration of Fluxin-AL (Alprazolam) in blood plasma.

    Simultaneous treatment with digoxin increases the risk of intoxication by cardiac glycosides.

    Fluxin-AL (Alprazolam) increases the concentration of imipramine in plasma.

    Simultaneous administration with itraconazole, ketoconazole increases the effects of Fluxin-AL (Alprazolam).

    Simultaneous administration with paroxetine may increases the effects of Fluxin-AL (Alprazolam) due to the inhibition of its metabolism.

    Fluvoxamine increases the concentration of Fluxin-AL (Alprazolam) in plasma and risk of its side effects.

    Simultaneous administration of Fluxin-AL (Alprazolam) with fluoxetine may increase the concentration of Fluxin-AL (Alprazolam) in plasma by decreasing its metabolism and clearance under the influence of fluoxetine which is accompanied by psychomotor disorders.

    It can not be exclude the possibility of strengthening effect of Fluxin-AL (Alprazolam) for simultaneous administration with erythromycin.

    Fluxin-AL in case of emergency / overdose

    Symptoms: Varying degrees of CNS oppression (from sleepiness to coma) - drowsiness, confusion; in more severe cases (especially in patients receiving other drugs depressing the central nervous system or alcohol) - ataxia, decreased reflexes, hypotension, coma.

    Treatment: induction of vomiting, gastric lavage, symptomatic therapy, monitor vital signs. In severe hypotension prescribed an injection of norepinephrine. Specific antidote is benzodiazepine receptor antagonist flumazenil (administration only in a hospital).

  • Fluoxetine Hydrochloride:


    Pharmacological action

    Fluxin-AL is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Fluxin-AL (Fluoxetine Hydrochloride) is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Fluxin-AL (Fluoxetine Hydrochloride) apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Fluxin-AL (Fluoxetine Hydrochloride) does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.

    Pharmacokinetics

    Fluxin-AL (Fluoxetine Hydrochloride) absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Fluxin-AL (Fluoxetine Hydrochloride) easily penetrates through the BBB.

    Fluxin-AL (Fluoxetine Hydrochloride) metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.

    T1/2 of Fluxin-AL (Fluoxetine Hydrochloride) is 2-3 days, norfluoxetine - 7-9 days.

    Why is Fluxin-AL prescribed?

    Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.

    Dosage and administration

    The initial dose of Fluxin-AL is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.

    The maximum oral daily dose for adults is 80 mg.

    Fluxin-AL (Fluoxetine Hydrochloride) side effects, adverse reactions

    CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.

    Digestive system: diarrhea, nausea.

    Metabolism: increased sweating, hypoglycemia, hyponatremia (especially in elderly patients and when hypovolemia).

    Reproductive system: decreased libido.

    Allergic reactions: skin rash, itching.

    Other: pain in joints and muscles, shortness of breath, increased body temperature.

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    Fluxin-AL contraindications

    Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Fluxin-AL (Fluoxetine Hydrochloride).

    Using during pregnancy and breastfeeding

    Fluxin-AL is contraindicated during pregnancy and lactation.

    Special instructions

    Fluxin-AL (Fluoxetine Hydrochloride) should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.

    Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Fluxin-AL (Fluoxetine Hydrochloride) increases the risk of epileptic seizures.

    With the simultaneous application of Fluxin-AL (Fluoxetine Hydrochloride) and electroconvulsive therapy may develop prolonged seizures.

    Fluxin-AL (Fluoxetine Hydrochloride) can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Fluxin-AL (Fluoxetine Hydrochloride) before therapy MAO inhibitors should not be less than 5 weeks.

    Elderly patients need correction of dosing regimen.

    Safety of Fluxin-AL (Fluoxetine Hydrochloride) in children has not been established.

    During the period of treatment it needed to avoid use alcohol.

    During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

    Fluxin-AL drug interactions

    Simultaneous administration of Fluxin-AL (Fluoxetine Hydrochloride) with:

  • drugs providing a depressing effect on the central nervous system and with ethanol it is possibly significantly increased inhibitory action on the CNS, as well as increasing the likelihood of developing seizures;
  • MAO inhibitors, furazolidone, procarbazine, tryptophan may develop serotonin syndrome (confusion, hypomanic state, motor restlessness, agitation, convulsions, dysarthria, hypertensive crisis, fever, tremor, nausea, vomiting, diarrhea);
  • Fluxin-AL (Fluoxetine Hydrochloride) inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, thereby increasing their concentration in serum, increase their therapeutic and side effects;
  • it is possible inhibition of the biotransformation of drugs metabolized with the participation of isoenzyme CYP2D6;
  • hypoglycemic agents may increase their activities;
  • haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, pyrathiazine, pimozide, risperidone, sulpiride, trifluoperazine there were describes cases of extrapyramidal symptoms and dystonia; with dextromethorphan - described a case of hallucinations; with digoxin - the case of increasing the concentration of digoxin in plasma;
  • with lithium salts may increase or decrease the concentration of lithium in blood plasma;
  • may increase the concentration of imipramine and desipramine in plasma is 2-10 times (and may persist for 3 weeks after discontinuation of Fluxin-AL (Fluoxetine Hydrochloride) Sanis Health);
  • propofol there was described a case in which spontaneous movements were observed; with phenylpropanolamine - described a case in which were observed dizziness, weight loss, hyperactivity;
  • may increase the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol. There are reports on the strengthening effects of warfarin in its simultaneous application with Fluxin-AL (Fluoxetine Hydrochloride).

    Fluxin-AL in case of emergency / overdose

    Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Fluxin-AL (Fluoxetine Hydrochloride) (in combination with maprotiline, codeine, temazepam).

    Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.

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    Fluxin-AL pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Fluxin-AL available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Fluxin-AL destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Fluxin-AL Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Fluxin-AL pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."SARAFEM (FLUOXETINE HYDROCHLORIDE) TABLET [ALLERGAN, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."NIRAVAM (ALPRAZOLAM) TABLET, ORALLY DISINTEGRATING [STAT RX USA LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. Dailymed."ALPRAZOLAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Fluxin-AL?

    Depending on the reaction of the Fluxin-AL after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Fluxin-AL not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Fluxin-AL addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Fluxin-AL, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Fluxin-AL consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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