Fludac

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Fludac uses


Pharmacological action

Fludac is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Fludac is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Fludac apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Fludac does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.

Pharmacokinetics

Fludac absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Fludac easily penetrates through the BBB.

Fludac metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.

T1/2 of Fludac is 2-3 days, norfluoxetine - 7-9 days.

Why is Fludac prescribed?

Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.

Dosage and administration

The initial dose of Fludac is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.

The maximum oral daily dose for adults is 80 mg.

Fludac side effects, adverse reactions

CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.

Digestive system: diarrhea, nausea.

Metabolism: increased sweating, hypoglycemia, hyponatremia.

Reproductive system: decreased libido.

Allergic reactions: skin rash, itching.

Other: pain in joints and muscles, shortness of breath, increased body temperature.

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Fludac contraindications

Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Fludac.

Using during pregnancy and breastfeeding

Fludac is contraindicated during pregnancy and lactation.

Special instructions

Fludac should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.

Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Fludac increases the risk of epileptic seizures.

With the simultaneous application of Fludac and electroconvulsive therapy may develop prolonged seizures.

Fludac can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Fludac before therapy MAO inhibitors should not be less than 5 weeks.

Elderly patients need correction of dosing regimen.

Safety of Fludac in children has not been established.

During the period of treatment it needed to avoid use alcohol.

During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

Fludac drug interactions

Simultaneous administration of Fludac with:

  • drugs providing a depressing effect on the central nervous system and with ethanol it is possibly significantly increased inhibitory action on the CNS, as well as increasing the likelihood of developing seizures;
  • MAO inhibitors, furazolidone, procarbazine, tryptophan may develop serotonin syndrome ;
  • Fludac inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, thereby increasing their concentration in serum, increase their therapeutic and side effects;
  • it is possible inhibition of the biotransformation of drugs metabolized with the participation of isoenzyme CYP2D6;
  • hypoglycemic agents may increase their activities;
  • haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, pyrathiazine, pimozide, risperidone, sulpiride, trifluoperazine there were describes cases of extrapyramidal symptoms and dystonia; with dextromethorphan - described a case of hallucinations; with digoxin - the case of increasing the concentration of digoxin in plasma;
  • with lithium salts may increase or decrease the concentration of lithium in blood plasma;
  • may increase the concentration of imipramine and desipramine in plasma is 2-10 times (and may persist for 3 weeks after discontinuation of Fludac Sanis Health);
  • propofol there was described a case in which spontaneous movements were observed; with phenylpropanolamine - described a case in which were observed dizziness, weight loss, hyperactivity;
  • may increase the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol. There are reports on the strengthening effects of warfarin in its simultaneous application with Fludac.

    Fludac in case of emergency / overdose

    Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Fludac (in combination with maprotiline, codeine, temazepam).

    Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.

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    Fludac pharmaceutical active ingredients containing related brand and generic drugs:


    Fludac available forms, composition, doses:


    Fludac destination | category:


    Fludac Anatomical Therapeutic Chemical codes:


    Fludac pharmaceutical companies:


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    References

    1. Dailymed."SARAFEM (FLUOXETINE HYDROCHLORIDE) TABLET [ALLERGAN, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "fluoxetine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "fluoxetine". http://www.drugbank.ca/drugs/DB0047... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Fludac?

    Depending on the reaction of the Fludac after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Fludac not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Fludac addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Fludac, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Fludac consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported useful

    How is the drug Fludac useful in reducing or relieving the symptoms? How useful is it?
    According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
    Visitors%
    Useful1
    100.0%

    One visitor reported side effects

    Did you get side effects while taking the Fludac drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Fludac medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    No side effects1
    100.0%

    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Fludac is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
    Visitors%
    Not expensive1
    100.0%

    Two visitors reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Fludac drug as prescribed by the doctor?

    Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Fludac is mentioned below.
    Visitors%
    Once in a day2
    100.0%

    One visitor reported doses

    What is the dose of Fludac drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    1-5mg1
    100.0%

    Two visitors reported time for results

    What is the time duration Fludac drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 3 month to notice the result from using Fludac drug. The time needed to show improvement in health condition after using the medicine Fludac need not be same for all the users. It varies based on other factors.
    Visitors%
    3 month1
    50.0%
    1 month1
    50.0%

    One visitor reported administration

    The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Fludac drug, before food or after food?
    Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
    Visitors%
    After food1
    100.0%

    One visitor reported age

    Visitors%
    16-291
    100.0%

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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