DRUGS & SUPPLEMENTS
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Ezipol is an inhibitor of H+ K+ ATPase. This medication inhibits the activity of H+-K+-ATPase in gastric parietal cells and thus blocks the final stage of hydrochloric acid secretion. This leads to a reduction in basal and stimulated secretion, regardless of the nature of the stimulus. Due to the reduction of acid secretion Ezipol reduces or normalizes the effects of acid in the esophagus in patients with reflux esophagitis.
Ezipol has a bactericidal effect on Helicobacter pylori. Eradication of H. pylori when Ezipol used with antibiotics allows to quickly arrest the symptoms, to take a high degree of healing of damaged mucosa and persistent long-term remission and reduce the likelihood of bleeding from the gastrointestinal tract.
After oral administration Ezipol is rapidly absorbed from the gastrointestinal tract. This drug penetrates the parietal cells of gastric mucosa. Plasma protein binding is about 95%. Ezipol is biotransformed in the liver. Excreted by the kidneys - 72-80%, in the faeces - about 20%. T1/2 is 0.5-1 h. In patients with chronic liver diseases T1/2 increases up to 3 hours.
Gastric ulcer and duodenal ulcer in acute phase (including associated with Helicobacter pylori), reflux esophagitis, Zollinger-Ellison syndrome, erosive and ulcerative lesions of gastric and duodenal ulcers associated with taking NSAIDs.
The dosing regimen of Ezipol is individual. When this medication is administered orally of the single dose is 20-40 mg. The daily dose is 20-80 mg, the frequency of use is 1-2 times / day. The duration of treatment is 2-8 weeks.
Digestive system: rarely - nausea, diarrhea, constipation, abdominal pain, flatulence.
CNS: rarely - headache, dizziness, weakness.
Hemopoietic system: in some cases - anemia, eosinopenia, neutropenia, thrombocytopenia.
Urinary system: in some cases - hematuria, proteinuria.
Musculoskeletal system: in some cases - arthralgia, muscle weakness, myalgia.
Allergic reactions: rarely - skin rash.
Chronic liver disease, hypersensitivity to Ezipol.
In the absence of clinical experience with Ezipol it is not recommended to use this drug during pregnancy. If necessary to use during Ezipol lactation it should been solve the issue of termination of breastfeeding.
Category effects on the fetus by FDA - C.
Before the treatment with Ezipol it is necessary to exclude the possibility of a malignant process because Ezipol treatment can mask symptoms and delay the correct diagnosis.
Therapy with Ezipol may affects results of laboratory studies of liver and gastrin concentrations in blood plasma.
Due to lack of experience in clinical application of Ezipol this medicine is not recommended for children.
This medication alters the bioavailability of any drug, absorption depends on pH (ketoconazole, iron salts, etc.). Ezipol slows down the elimination of drugs metabolized in the liver by microsomal oxidation (warfarin, diazepam, phenytoin, etc.).
Ezipol enhances the action of coumarin and diphenine, does not change - NSAIDs. This drug increases (relative) the concentration of clarithromycin in the blood; may increases the leukopenic and thrombocytopenic effects of depressants hematopoiesis drugs. Substance for intravenous infusion is compatible only with saline and dextrose (using other solvents may decrease the stability of Ezipol due to changes in pH of infusion medium).
Symptoms: dry mouth, nausea, blurred vision, headache, increased sweating, flushing, tachycardia, drowsiness, confusion.
Treatment: symptomatic, dialysis is ineffective.
Depending on the reaction of the Ezipol after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ezipol not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Ezipol addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology