DRUGS & SUPPLEMENTS
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Etovas-EZ is a lipid-lowering drugs of the statin group. An inhibition of HMG-CoA reductase leads to a series of sequential reactions that result in reduced intracellular cholesterol content and it is a compensatory increase in activity of LDL receptors and thus accelerate the catabolism of LDL cholesterol.
The lipid-lowering effect of statins is associated with lower levels of total cholesterol by LDL-C. The reduction in LDL cholesterol is dose-dependent and is not linear, but exponential. The inhibitory effect of Etovas-EZ (Atorvastatin) on HMG-CoA reductase by about 70% determined by the activity of its circulating metabolites.
Statins do not affect the activity of lipoprotein lipase and hepatic, no significant effect on the synthesis and catabolism of free fatty acids, so their effect on triglycerides and again vicariously through their main effects on reducing LDL-C.
In addition to lipid-lowering actions, statins have beneficial effects in endothelial dysfunction (pre-clinical sign of early atherosclerosis) in the vascular wall, the state of atheroma, improves blood rheology, have antioxidant, antiproliferative properties.
Etovas-EZ (Atorvastatin) lowers cholesterol levels in patients with homozygous familial hypercholesterolemia, which is usually not amenable to therapy with lipid-lowering agents.
Etovas-EZ (Atorvastatin) is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability is low (about 12%) due to first-pass clearance in gastrointestinal mucosa and / or due to the "first pass" through the liver, predominantly in the scene. Etovas-EZ (Atorvastatin) is metabolized with the participation of isoenzyme CYP3A4 to form a number of substances which are inhibitors of HMG-CoA reductase inhibitors.
T1/2 from plasma is about 14 hours, although the T1/2 inhibitor activity of HMG-CoA reductase is approximately 20-30 hours, due to the involvement of active metabolites.
The plasma protein binding is 98%.
Etovas-EZ (Atorvastatin) is excreted in the form of metabolites mainly in the bile.
Primary hypercholesterolemia in ineffectiveness of diet, combined hypercholesterolemia and hypertriglyceridemia, heterozygous and homozygous familial hypercholesterolemia with the ineffectiveness of diet.
The treatment by Etovas-EZ is with a standard diet for patients with hypercholesterolemia. The dose is determined individually, depending on the initial cholesterol levels. This medication is taken orally. The initial dose is usually 10 mg 1 time / day. The effect is manifested within 2 weeks, and the maximum effect is for 4 weeks. If necessary, the dose can be gradually increased every 4 weeks or more. The maximum daily dose is 80 mg.
Digestive system: constipation, flatulence, dyspepsia, abdominal pain, nausea, diarrhea.
CNS and peripheral nervous system: headache, insomnia.
Other: asthenia, myalgia.
Liver disease in the active phase, increasing the serum transaminase activity more than 3 times of unknown origin, pregnancy, lactation (breastfeeding), hypersensitivity to Etovas-EZ (Atorvastatin). Women of reproductive age not using reliable contraception.
Etovas-EZ is contraindicated during pregnancy and lactation (breastfeeding).
It is not known whether Etovas-EZ (Atorvastatin) is allocated in breast milk. Given the potential for adverse effects in infants, if necessary to use this drug during lactation it should decide on the termination of breastfeeding.
Women of reproductive age during treatment should use adequate contraceptive methods. Etovas-EZ (Atorvastatin) may be used in women of childbearing age only if the probability of pregnancy is very low, and the patient informed about the possible risk of treatment for the fetus.
Category of the fetus by FDA - X.
Prior to and during treatment with Etovas-EZ (Atorvastatin), especially if symptoms of liver damage, it is necessary to monitor liver function tests. With an increase in transaminase levels it should be monitored their activity up to normalization. If AST or ALT more than 3 times the norm persists, we recommend reducing the dose or withdrawal of Etovas-EZ (Atorvastatin).
When prompted during the treatment of symptoms of myopathy it should determine the activity of creatine kinase. If a significant increase in CK levels is preserved, it is recommended to reduce the dose of Etovas-EZ (Atorvastatin) or to cancel taking it.
The risk of myopathy during the treatment with Etovas-EZ (Atorvastatin) increased, while the use of cyclosporine, fibrates, erythromycin, antifungal agents belonging to azoles, and niacin.
There is a likelihood of the following side effects, but not in all cases, a clear link with taking Etovas-EZ (Atorvastatin): muscle cramps, myositis, myopathy, paresthesia, peripheral neuropathy, pancreatitis, hepatitis, cholestatic jaundice, anorexia, vomiting, alopecia, pruritus, rash, impotence, hyperglycemia and hypoglycemia.
The children experience of Etovas-EZ (Atorvastatin) using at a dose of 80 mg / day is restricted.
With careful use Etovas-EZ (Atorvastatin) in patients with chronic alcoholism.
When this drug applied simultaneously with:
- digoxin slightly increased concentration of digoxin in plasma.
- itraconazole greatly increases the concentration of Etovas-EZ (Atorvastatin) in plasma, apparently due to inhibition of itraconazole its metabolism in the liver that occurs with the participation of isoenzyme CYP3A4; increased risk of myopathy.
- colestipol may decrease the concentration of Etovas-EZ (Atorvastatin) in plasma, with lipid-lowering effect is enhanced.
- antacids containing magnesium hydroxide and aluminum hydroxide, reduce the concentration of Etovas-EZ (Atorvastatin) by approximately 35%.
- cyclosporine, fibrates (including gemfibrozil), azole antifungals derivatives, nicotinic acid increases the risk of myopathy.
- erythromycin, clarithromycin moderately increased concentrations of Etovas-EZ (Atorvastatin) in plasma, increases the risk of myopathy.
- ethinyl estradiol, norethisterone (norethindrone) slightly increases the concentration of ethinyl estradiol, norethisterone and (norethindrone) in blood plasma.
- protease inhibitors increases the concentration of Etovas-EZ (Atorvastatin) in plasma, as protease inhibitors are inhibitors of the CYP3A4 isoenzyme.
Diltiazem, verapamil, isradipine inhibit isoenzyme CYP3A4, which participates in the metabolism of Etovas-EZ (Atorvastatin) Sanis Health, so that while the use of these calcium channel blockers may increase the concentration of Etovas-EZ (Atorvastatin) in plasma and increased risk of myopathy.
Treatment: symptomatic and supportive therapy. There is no specific antidote. Hemodialysis is ineffective.
Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio belongs to antihyperlipidemic category of drugs. Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio is best effective in lowering the amount of absorbable amount of cholesterol in body. This drug amazingly reduces the amount of total cholesterol and LDL (bad) cholesterol. The power of Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio doesn't stop here. It also reduces the amount of apolipoprotein B protein that creates cholesterol in the blood. Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio is the physician's first choice in bringing down cholesterol and tri-glyceride level in blood. Often, prescribed to be taken with low cholesterol diet and complementary lipid reducing drugs, Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio is capable of stopping physical problems due to blocked blood vessels. Apart from this, Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio is often used by doctors for treating other diseases. Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio cuts short all the life threatening risk factors caused due to higher cholesterol levels in blood. Patients suffering from cholesterol related problems may find this drug to be very effective and useful if taken regularly.
Inform your doctor before taking Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio if you have liver disease or any kind of muscle pain or weakness. It is also safer to let the doctor know if you are taking any other such cholesterol reducing drug or restricted diet. Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio may not work to the fullest if you are suffering from overweight. Although it has not been tested on pregnant women, it has shown birth defects when tested on animal.
There is still doubt as to whether Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio passes into breast milk or not. But it is apprehended that it may cause serious disorders in nursing babies. So it is always recommended to consult your doctor if you are pregnant or breast-feeding before taking this drug. Children under the age of 10 should not be put on this drug. Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio is not yet tested on older patients and is also not expected to create harmful effects in them.
Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio may not work in harmony with other drugs. Let your physician know if you are taking any of the following drugs:
Cholesterol-reducing drugs like such as gemfibrozil
Intake of Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio is followed by a host of side effects. Stop taking this drug instantly if you experience breathing trouble, closed throat, swollen lips, tongue, or face and take required medical aid from your doctor.
Side effects like high body temperature, headache, muscle pain, running nose, sore throat, body ache, chest pain, congestion, cough, diarrhea, difficulty in moving, drowsiness, stomach pain, soft and swollen glands in neck, tightness of chest, difficulty in swallowing, fatigue and voice changes are very common and less harmful.
Amongst the less found side effects of Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio, huge swelling of face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs, skin rash etc. are notable. Always seek a doctor's help if any of these side effects appears.
Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio works wonder only when taken regularly and properly. Overdose of Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio is not recommended and can be harmful. Symptoms of overdose are, however, not known. Nevertheless, rush to a doctor as soon as you feel that you have taken in a double dose.
Missing a dose of Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio may not be that harmful. Take the missed dose as soon as you remember. But if it is almost time for the next dose, skip the missed one and go for the scheduled one. time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of the medication.
Your physician is the best person to provide you with the right usage guidelines. Regularity and punctuality are the keywords. Generally, it can be said that, Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio is taken with a full glass of water, once a day with or without food. If you are on bile acid sequestrant such as Cholestyramine (Locholest, Prevalite, Questran), colestipol (Colestid), or colesevelam (Welchol), take Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio 2 hours before or 4 hours after taking the acid sequestrant. While you are on Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio mediaction, take food low on cholesterol. Do not ignore taking medical tests if your doctor asks for. Also dont stop taking Etovas-EZ (Ezetimibe) Dr. Lazar Laboratorio without your doctor's approval.
Depending on the reaction of the Etovas-EZ after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Etovas-EZ not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Etovas-EZ addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology