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Estradiol uses

Estradiol information

Estradiol is a female sex hormone that regulates many functions in the female organism. This medicine is currently available under the form of tablets in two concentrations - 1 mg and 2 mg, respectively.

Estradiol indications

Estradiol is used for the treatment of menopausal symptoms such as vaginal dryness, irritation or burning, or hot flushes - other symptoms that are not listed here may be treated with this medicine as well. Also, this pharmaceutical preparation can be used as a prophylactic agent for the prevention of a medical condition known as osteoporosis in both female and male patients. In some cases, this medicine may also be employed in conjunction with other drugs as part of the treatment for certain types of cancer, both in the case of women and men.

There may be other uses for Estradiol, which are not covered in this leaflet. If you are interested to find out more about the possible uses of this product, it is recommended that you consult with a pharmacist or a specialized physician.

Estradiol warnings

Estradiol should not be administered to patients that are suffering from any type of disorder involving blood clots, or from circulatory / cardiac disorders. Patients who present an undiagnosed, abnormal vaginal bleeding may not start taking this medicine until they undergo medical examination and receive their physician's approval. Also, patients that have uterine cancer, breast cancer or any type of hormone-dependant cancer may not start a treatment with Estradiol.

Before you start a therapy course with this drug, it is strongly advised to inform your personal physician of any health problems you may be suffering from. In particular, affections such as hypertension, heart disease, angina, high triglyceride / cholesterol levels, renal or hepatic disease, asthma, migraines, epilepsy, diabetes or gallbladder disease should be mentioned, as well as past surgical procedures such as a hysterectomy. Patients suffering from these conditions may require special dosage adjustments or monitoring during the treatment.

Estradiol may not be administered during pregnancy. Also, for the duration of the therapy you will need to employ an effective, non-hormonal contraceptive method.

Pharmaceutical products based on Estradiol (including Estradiol) increase the patients' risk of developing an affection known as endometrial hyperplasia. This can be countered by administration of progestin medication. It is recommended that you consult with your doctor for more information.


Estradiol intake guidelines

You need to take Estradiol exactly as directed by your health care specialist. You may take the tablets with a glass of water or with food to reduce stomach upset; however you may not chew, crush or break the tablets.

While following a treatment course with Estradiol you will need to undergo regular medical examination, typically on a monthly basis. Also, you will need to regularly self-examine your breasts for the presence of lumps.

Estradiol dosage

Your health care specialist will determine the Estradiol dosage appropriate for your case by taking into consideration a number of factors, most of which are characteristic to you; as such, your medication dosage is very likely to be different from that of other patients'. Because of that, you should never use the Estradiol dosage that has been prescribed to another patient - you may not obtain the desired results unless you employ the medication dosage best suited for your situation.

At the same time, your physician will inform you regarding the duration of the Estradiol therapy and the number of daily intakes. Make sure that you understand all of his or her indications. If you have trouble understanding or remembering any of the dosage directions, you should ask your physician to assist you by providing additional information.

Estradiol overdose

If an overdose with Estradiol is suspected, immediately contact the nearest hospital as the patient may need emergency medical assistance. The most common signs of an overdose are vaginal bleeding, nausea and vomiting.

Estradiol missed dose

In the event that you miss taking one of your Estradiol doses, take it when you remember before returning to your normal dosing schedule. However, you should skip taking the missed dose if it is almost time for another dose of the medicine. Consult with your physician if you have missed two or more intakes.

Estradiol side effects

Side effects of a treatment with Estradiol include nausea and vomiting, loss of appetite, swelling of the breasts, sex drive changes, impotence, abnormal vaginal bleeding, vaginal dryness, discomfort or pain, break-through bleeding, menstrual period changes, jaundice, sudden weakness or numbness, breast lumps. These are not all the signs and symptoms that may appear. It is best that you check with your doctor at any point during the course of your therapy if anything unusual occurs.

Although uncommon, allergic reactions to Estradiol are possible. It is strongly recommended that you cease taking the medicine and contact your personal health care provider if you begin experiencing any of the characteristic symptoms - breathing difficulties, swelling of the throat, lips, tongue or face, rashes and hives.

Estradiol drug reactions

Estradiol may interact with Phenobarbital, Phenytoin, Ritonavir, Cimetidine, Carbamazepine, Rifampin, blood thinning agents such as Warfarin or with antibiotics (Clarithromycin, Erythromycin, Ketoconazole or Itraconazole). Also, this product may interact with the herbal remedy St. John's wort. These are not all the possible drug reactions; it is best that you tell your prescriber about any other drugs you are currently taking prior to starting your treatment. In most cases, an adjustment to the medication dosage will ensure the safety of the treatment, reducing the risk of accidental interactions.


Estradiol pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

Estradiol available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Alora 0.025 mg patch6.26 USD
Alora 0.05 mg patch6.86 USD
Alora 0.075 mg patch7.0 USD
Alora 0.1 mg patch7.16 USD
Alora 8 0.05 mg/24hr Patches Box60.99 USD
Alora 8 0.075 mg/24hr Patches Box58.27 USD
Alora 8 0.1 mg/24hr Patches Box62.99 USD
Climara 0.025 mg/day patch15.77 USD
Climara 0.0375 mg/24hr Patches17.26 USD
Climara 0.0375 mg/day patch15.77 USD
Climara 0.05 mg/day patch15.77 USD
Climara 0.06 mg/24hr Patches17.26 USD
Climara 0.06/mg day patch15.77 USD
Climara 0.075 mg/day patch15.77 USD
Climara 0.1 mg/day patch15.77 USD
Climara 100 (7.8 Mg/Pth) 100 mcg/day Patch6.67 USD
Climara 25 (2 Mg/Pth) 25 mcg/day Patch5.54 USD
Climara 4 0.025 mg/24hr Patches Box75.58 USD
Climara 4 0.05 mg/24hr Patches Box75.58 USD
Climara 4 0.075 mg/24hr Patches Box69.04 USD
Climara 4 0.1 mg/24hr Patches Box75.58 USD
Climara 50 (3.9 Mg/Pth) 50 mcg/day Patch5.91 USD
Climara 75 (5.7 Mg/Pth) 75 mcg/day Patch6.31 USD
Climara Pro 4 0.045-0.015 mg/day Patches Box69.04 USD
Climara pro patch15.77 USD
CombiPatch 0.05-0.14 mg/day Patches8.65 USD
CombiPatch 8 0.05-0.25 mg/day Patches Box66.45 USD
Combipatch 0.05-0.14 mg ptch7.92 USD
Combipatch 0.05-0.25 mg ptch7.91 USD
Delestrogen 10 mg/ml Oil 5ml Vial88.04 USD
Delestrogen 10 mg/ml vial16.25 USD
Delestrogen 20 mg/ml Oil23.82 USD
Delestrogen 20 mg/ml vial22.91 USD
Delestrogen 40 mg/ml Oil39.52 USD
Delestrogen 40 mg/ml vial38.0 USD
Depo-Estradiol 5 mg/ml Oil9.66 USD
Depo-estradiol 5 mg/ml vial7.89 USD
Divigel 0.25 mg gel packet2.74 USD
Divigel 0.5 mg gel packet2.74 USD
Divigel 0.5 mg/0.5 gm Gel Box72.99 USD
Divigel 1 mg gel packet2.74 USD
Divigel 1 mg/gm Gel Box Of 30 gm85.53 USD
Divigel 30 0.25 mg/0.25 gm Gel 30 Patches/box81.24 USD
Elestrin 0.06% gel0.94 USD
Elestrin 0.52 mg/0.87 gm(0.06%) Gel 144 gm Bottle162.06 USD
Estrace 0.01% cream3.05 USD
Estrace 0.1 mg/gm Cream 42.5 gm Tube133.27 USD
Estrace 0.5 mg tablet0.13 USD
Estrace 1 mg tablet0.25 USD
Estrace 2 mg tablet0.44 USD
Estraderm 0.05 mg patch8.07 USD
Estraderm 0.1 mg patch8.66 USD
Estraderm 8 0.05 mg/24hr Patches Box66.35 USD
Estraderm 8 0.1 mg/24hr Patches Box72.47 USD
Estraderm-100 (8.0 Mg/Pth) 100 mcg/day Patch4.52 USD
Estraderm-25 (2 Mg/Pth) 25 mcg/day Patch3.74 USD
Estradiol 0.05 mg/day patch16.91 USD
Estradiol 0.1 mg/day patch20.55 USD
Estradiol 0.5 mg tablet0.36 USD
Estradiol 1 mg tablet0.42 USD
Estradiol 2 mg tablet0.49 USD
Estradiol 4 0.025 mg/24hr Patches Box40.92 USD
Estradiol 4 0.0375 mg/24hr Patches Box39.35 USD
Estradiol 4 0.05 mg/24hr Patches Box40.92 USD
Estradiol 4 0.06 mg/24hr Patches Box39.99 USD
Estradiol 4 0.075 mg/24hr Patches Box40.92 USD
Estradiol 4 0.1 mg/24hr Patches Box40.92 USD
Estradiol benzoate powder42.0 USD
Estradiol cypionate powder88.74 USD
Estradiol powder17.86 USD
Estradiol tds 0.025 mg/day9.84 USD
Estradiol tds 0.0375 mg/day9.84 USD
Estradiol tds 0.06 mg/day9.84 USD
Estradiol tds 0.075 mg/day9.84 USD
Estradiol valerate 10 mg/ml vial15.24 USD
Estradiol valerate 20 mg/ml vial21.25 USD
Estradiol valerate 40 mg/ml vial35.62 USD
Estradiol valerate powder32.13 USD
Estradot 100 (1.56 Mg/Pth) 100 mcg/day Patch3.49 USD
Estradot 25 (0.39 Mg/Pth) 25 mcg/day Patch2.86 USD
Estradot 37.5 (0.585 Mg/Pth) 37.5 mcg/day Patch2.88 USD
Estradot 50 (0.78 Mg/Pth) 50 mcg/day Patch3.07 USD
Estradot 75 (1.17 Mg/Pth) 75 mcg/day Patch3.3 USD
Estrasorb 4.35 mg/1.74 gm Emulsion 1.74 gm Packet2.83 USD
Estrasorb packet1.21 USD
Estring 2 mg Ring Box210.39 USD
Estring 2 mg Slow-Release Ring65.39 USD
Estring 2 mg vaginal ring202.3 USD
Estrogel 0.06 % Gel0.31 USD
Estrogel 0.06% gel1.63 USD
Estrogel 0.75 mg/1.25 gm(0.06%) Gel 50 gm Bottle84.24 USD
Ethinyl estradiol powder140.0 USD
Evamist 1.53 mg/spray10.43 USD
Evamist 1.53 mg/spray Solution 8.1ml Bottle87.18 USD
Femring 0.05 mg vaginal ring197.26 USD
Femring 0.05 mg/24hr Ring205.15 USD
Femring 0.1 mg/24hr Ring218.6 USD
Femring 0.10 mg vaginal ring210.19 USD
Femtrace 0.45 mg tablet2.02 USD
Femtrace 0.9 mg tablet2.02 USD
Femtrace 1.8 mg tablet2.59 USD
Film, Extended Release; Transdermal; Estradiol 0.025 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.0375 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.05 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.06 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.075 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.1 mg / 24 h
Gynodiol 1.5 mg tablet0.5 USD
Menest 0.3 mg tablet0.89 USD
Menest 0.625 mg tablet1.41 USD
Menest 1.25 mg tablet1.56 USD
Menest 2.5 mg tablet2.6 USD
Menostar 4 14 mcg/24hr Patches Box73.18 USD
Oesclim 25 (5 Mg/Pth) 25 mcg/day Patch2.83 USD
Oesclim 50 (10 Mg/Pth) 50 mcg/day Patch3.06 USD
Patch; Topical; Estradiol 50 mcg / 24 h
Sandoz Estradiol Derm 100 (8 Mg/Pth) 100 mcg/day Patch2.64 USD
Sandoz Estradiol Derm 50 (4 Mg/Pth) 50 mcg/day Patch2.34 USD
Sandoz Estradiol Derm 75 (6 Mg/Pth) 75 mcg/day Patch2.5 USD
Tablets; Oral; Estradiol 0.5 mg
Tablets; Oral; Estradiol 1 mg
Tablets; Oral; Estradiol 2 mg
Vagifem 10 mcg vaginal tab6.78 USD
Vagifem 18 25 mcg tablet Box139.78 USD
Vagifem 25 mcg Tablet3.21 USD
Vagifem 25 mcg vaginal tab6.78 USD
Vagifem 8 10 mcg tablet Box54.99 USD
Vagifem 8 25 mcg tablet Box58.23 USD
Vivelle 0.05 mg patch5.74 USD
Vivelle 0.1 mg patch5.94 USD
Vivelle 8 0.05 mg/24hr Patches Box49.99 USD
Vivelle-Dot 8 0.025 mg/24hr Patches Box70.69 USD
Vivelle-Dot 8 0.0375 mg/24hr Patches Box68.84 USD
Vivelle-Dot 8 0.05 mg/24hr Patches Box65.99 USD
Vivelle-Dot 8 0.075 mg/24hr Patches Box66.89 USD
Vivelle-Dot 8 0.1 mg/24hr Patches Box72.46 USD
Vivelle-dot 0.025 mg patch7.53 USD
Vivelle-dot 0.0375 mg patch7.54 USD
Vivelle-dot 0.05 mg patch7.61 USD
Vivelle-dot 0.075 mg patch8.49 USD
Vivelle-dot 0.1 mg patch7.89 USD


Estradiol destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

Estradiol Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

Estradiol pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



  1. Dailymed."ESTRADIOL TABLET [TEVA PHARMACEUTICALS USA, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."ESTRADIOL HEMIHYDRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "estradiol". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Estradiol?

Depending on the reaction of the Estradiol after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Estradiol not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Estradiol addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.



sDrugs.com conducted a study on Estradiol, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Estradiol consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Estradiol drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Estradiol is mentioned below.
Once in a day1

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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