Erythromycin

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Erythromycin uses


Pharmacological action

Erythromycin is a macrolide antibiotic. Has bacteriostatic action. However at higher doses against susceptible organisms has a bactericidal effect. Erythromycin is reversibly bound to the ribosome of bacteria, thereby inhibiting protein synthesis. Erythromycin is active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae); gram-negative bacteria: Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp., Bacillus anthracis, Corynebacterium diphtheriae; anaerobic bacteria: Clostridium spp. Erythromycin is also active against Mycoplasma spp., Chlamydia spp., Spirochaetaceae, Rickettsia spp. To Erythromycin resistant gram-negative bacilli, including Escherichia coli, Pseudomonas aeruginosa, Shigella spp., Salmonella spp.

Pharmacokinetics

Erythromycin bioavailability is 30-65%. Distributed in most tissues and body fluids. Plasma protein binding is 70-90%. Metabolised in the liver, partly with the formation of inactive metabolites. T1/2 is 1.4-2 hours. It is derived from bile and urine.

Why is Erythromycin prescribed?

Infectious-inflammatory diseases caused by microorganisms sensitive to Erythromycin, including diphtheria, pertussis, trachoma, brucellosis, a disease Legionnaires, sore throat, scarlet fever, otitis media, sinusitis, cholecystitis, pneumonia, gonorrhea, syphilis. Also Erythromycin used for the treatment of infectious-inflammatory diseases caused by pathogens are resistant to penicillin, tetracycline, chloramphenicol, streptomycin.

For external use: acne vulgaris.

For local use: the infectious-inflammatory diseases of eyes.

Dosage and administration

Erythromycin prescribed individually depending on the location and severity of infection, the sensitivity of the parasite. In adults use a daily dose of 1-4 g. Children under the age of 3 months - 20-40 mg / kg / day, aged from 4 months to 18 years - 30-50 mg / kg / day. Multiplicity is 4 times / day. The treatment course - 5-14 days after the disappearance of symptoms treatment should be continued for a further 2 days. Accepts up to 1 hour before eating or 2-3 hours after eating.

Solution for external applications lubricate the affected skin.

The ointment is applied to the affected area and in diseases of the eye lay behind the lower eyelid. The dose, frequency and duration of application is determined individually.

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Erythromycin side effects, adverse reactions

Digestive system: nausea, vomiting, epigastric pain, cholestatic jaundice, tenesmus, diarrhea, dysbacteriosis; rarely - pseudomembranous enterocolitis, abnormal liver function, increase in liver transaminases, pancreatitis.

Allergic reactions: skin rash, urticaria, eosinophilia, rarely - anaphylactic shock.

Effects due to the influence of chemotherapy: oral candidiasis, vaginal candidiasis.

From the senses: the reversible ototoxicity - hearing loss and / or tinnitus.

Since the cardiovascular system: rarely - tachycardia, prolongation of the QT interval on ECG, flickering and / or atrial flutter (patients with long QT interval on the ECG).

Local reactions: phlebitis at the site of / in the introduction.

Erythromycin contraindications

Jaundice in history, marked disturbances of liver function, hypersensitivity to macrolides.

Using during pregnancy and breastfeeding

Erythromycin crosses the placental barrier, excreted in breast milk.

In the application of Erythromycin in pregnancy should assess the intended benefits to the mother and the potential risk to the fetus. If necessary, use during lactation should decide on the termination of breastfeeding.

Special instructions

With careful use Erythromycin when disorders of liver function and / or kidneys. Medications that increase the acidity of gastric juice and acidic drinks inactivate Erythromycin. Erythromycin can not drink milk and dairy products.

Precautionary measures

The use of Erythromycin containing benzene for IV injection sometimes accompanied by the development of a fatal syndrome Gaspinga in children, as well as acute hepatitis drug in adults and children.

Erythromycin drug interactions

With simultaneous use of Erythromycin with theophylline, aminophylline, caffeine, there is an increase in their concentration in blood plasma and thus increases the risk of toxic effects.

Erythromycin increases the concentrations of cyclosporine in the blood plasma and may increase the risk of nephrotoxicity.

Drugs that block tubular secretion prolongs T1/2 of Erythromycin.

Incompatible with lincomycin, clindamycin and chloramphenicol.

Erythromycin reduces the bactericidal action of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems).

With simultaneous use of Erythromycin increases the concentration of theophylline.

At the same time receiving chemotherapy, which is carried metabolism in the liver (carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, dizopiramid, lovastatin, bromocriptine), may increase the concentration of these drugs in plasma (an inhibitor of microsomal liver enzymes).

IV injection of Erythromycin increases the effects of ethanol (accelerating gastric emptying and decrease the duration of alcohol dehydrogenase in the gastric mucosa).

Erythromycin reduces the clearance of triazolam and midazolam and therefore may increase the pharmacological effects of benzodiazepines.

At the same time taking with terfenadine or astemizole may develop arrhythmias (fibrillation and ventricular flutter, ventricular tachycardia, until death); with dihydroergotamine or non hydrated ergot alkaloids may vasoconstriction to spasm, dysesthesia.

With simultaneous application Erythromycin slows elimination (increases the effect) of methylprednisolone, felodipine and anticoagulants of cumarine series.

In a joint appointment with lovastatin increased rhabdomyolysis.

Erythromycin increases the bioavailability of digoxin.

Erythromycin reduces the effectiveness of hormonal contraceptives.

Erythromycin in case of emergency / overdose

Symptoms: disruption of the liver until the acute liver failure, and hearing loss.

Treatment: gastric lavage, forced diuresis, hemo-and peritoneal dialysis. Produced a constant monitoring of vital functions (ECG, electrolyte composition of blood).

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Erythromycin pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Erythromycin available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Akne-mycin 2% ointment3.96 USD
Apo-Erythro Base 250 mg Tablet0.19 USD
Apo-Erythro E-C 250 mg Capsule (Enteric-Coated Pellet)0.41 USD
Apo-Erythro E-C 333 mg Capsule (Enteric-Coated Pellet)0.45 USD
Apo-Erythro-Es 600 mg Tablet0.35 USD
Apo-Erythro-S 250 mg Tablet0.22 USD
Apo-Erythro-S 500 mg Tablet0.57 USD
Benzamycin 5-3% Gel 46.6 gm Jar236.63 USD
Benzamycin gel4.95 USD
BenzamycinPak 60 5-3% Packets (2 Box Contains 60 Packets)142.45 USD
Benzamycinpak gel2.37 USD
Capsules, Delayed Release; Oral; Erythromycin 250 mg
Capsules; Oral; Erythromycin 250 mg
Capsules; Oral; Erythromycin 500 mg
E-mycin 333 mg tablet ec0.54 USD
E.e.s. 400 filmtab0.25 USD
Emgel 2% topical gel1.07 USD
Ery-Tab 250 mg Enteric Coated Tabs0.45 USD
Ery-Tab 333 mg Enteric Coated Tabs0.72 USD
Ery-Tab 500 mg Enteric Coated Tabs0.93 USD
Ery-tab 250 mg tablet ec0.27 USD
Ery-tab 333 mg tablet ec0.4 USD
Ery-tab 500 mg tablet ec0.77 USD
Ery-tab ec 500 mg tablet0.46 USD
Eryc 250 mg Capsule (Enteric-Coated Pellet)0.54 USD
Eryc 333 mg Capsule (Enteric-Coated Pellet)0.6 USD
Erycette 60 2% Pad Box30.99 USD
Eryderm 2% Solution 60ml Bottle25.99 USD
Erythro-rx powder0.72 USD
Erythrocin 250 mg filmtab0.16 USD
Erythrocin 500 mg filmtab0.29 USD
Erythromycin 2% Gel 30 gm Tube26.2 USD
Erythromycin 2% Gel 60 gm Tube46.8 USD
Erythromycin 2% Solution 60ml Bottle26.13 USD
Erythromycin 2% gel0.5 USD
Erythromycin 250 mg filmtab0.25 USD
Erythromycin 5 mg/gm Ointment Limited Supply Available.13.99 USD
Erythromycin 500 mg filmtab0.3 USD
Erythromycin Base 250 mg Enteric Coated Capsule0.5 USD
Erythromycin Base 250 mg tablet0.5 USD
Erythromycin Base 500 mg tablet0.61 USD
Erythromycin e.s. powder2.39 USD
Erythromycin ec 500 mg tablet0.66 USD
Erythromycin es 400 mg tablet0.25 USD
Erythromycin eye ointment1.44 USD
Erythromycin powder0.54 USD
Erythromycin st 500 mg tablet0.44 USD
Gel; Topical; Erythromycin 2%
Injectable; Injection; Erythromycin 1 g
Novo-Rythro Ees 40 mg/ml Suspension0.1 USD
Novo-Rythro Ees 80 mg/ml Suspension0.15 USD
Novo-Rythro Estolate 50 mg/ml Suspension0.13 USD
Ointment; Ophthalmic; Erythromycin 0.5%
Ointment; Ophthalmic; Erythromycin 10,000 IU / g
Ointment; Ophthalmic; Erythromycin 5 mg / g
Ointment; Topical; Erythromycin 10,000 IU / g
PCE 333 mg Enteric Coated Tabs2.48 USD
PCE 500 mg Enteric Coated Tabs3.28 USD
Pce 333 mg dispertab2.3 USD
Pce 500 mg dispertab3.03 USD
Pms-Erythromycin 0.5 % Ointment1.3 USD
Powder for Suspension; Oral; Erythromycin 200 mg / 5 ml
Powder for Suspension; Oral; Erythromycin 400 mg / 5 ml
Romycin eye ointment1.98 USD
Solution; Topical; Erythromycin 2%
Suspension; Oral; Erythromycin 125 mg / 5 ml
Suspension; Oral; Erythromycin 250 mg / 5 ml
Suspension; Oral; Erythromycin 500 mg / 5 ml
Swab; Topical; Erythromycin 2%
Tablets, Enteric Coated; Oral; Erythromycin 100 mg
Tablets, Enteric Coated; Oral; Erythromycin 200 mg
Tablets, Enteric Coated; Oral; Erythromycin 250 mg
Tablets, Enteric Coated; Oral; Erythromycin 500 mg
Tablets, Film-Coated; Oral; Erythromycin 250 mg
Tablets; Oral; Erythromycin 250 mg
Tablets; Oral; Erythromycin 500 mg

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Erythromycin destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Erythromycin Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Erythromycin pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."ERYTHROMYCIN BASE (ERYTHROMYCIN) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."ERYTHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "erythromycin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Erythromycin?

Depending on the reaction of the Erythromycin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Erythromycin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Erythromycin addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Erythromycin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Erythromycin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Erythromycin useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Useful1
100.0%

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Erythromycin drug as prescribed by the doctor?

Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Erythromycin is mentioned below.
Visitors%
Twice in a day1
100.0%

Three visitors reported doses

What is the dose of Erythromycin drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
201-500mg3
100.0%

One visitor reported time for results

What is the time duration Erythromycin drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed > 3 month to notice the result from using Erythromycin drug. The time needed to show improvement in health condition after using the medicine Erythromycin need not be same for all the users. It varies based on other factors.
Visitors%
> 3 month1
100.0%

Visitor reported administration

No survey data has been collected yet

Three visitors reported age

Visitors%
30-451
33.3%
16-291
33.3%
46-601
33.3%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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