Dramin B-6

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Dramin B-6 uses

Dramin B-6 consists of Dimenhydrinate, Vitamin B6 (Pyridoxine Hydrochloride).

Dimenhydrinate:


INDICATIONS AND USAGE

Dramin B-6 (Dimenhydrinate) Injection, USP is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.

CONTRAINDICATIONS

Neonates and patients with a history of hypersensitivity to Dramin B-6 (Dimenhydrinate) or its components (diphenhydramine or 8-chlorotheophylline) should not be treated with Dramin B-6 (Dimenhydrinate).

Note: This product contains Benzyl Alcohol. Benzyl Alcohol has been associated with a fatal “Gasping Syndrome” in premature infants and infants of low birth weight.

WARNINGS

Caution should be used when Dramin B-6 is given in conjunction with certain antibiotics that may cause ototoxicity, since Dramin B-6 (Dimenhydrinate) is capable of masking ototoxic symptoms, and an irreversible state may be reached.

This drug may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. The concomitant use of alcohol or other central nervous system depressants may have an additive effect. Therefore, patients should be warned accordingly.

Dramin B-6 (Dimenhydrinate) should be used with caution in patients having conditions which might be aggravated by anticholinergic therapy (i.e., prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, bladder neck obstruction, narrow-angle glaucoma, bronchial asthma, or cardiac arrhythmias).

The preparation should not be injected intra-arterially.

Pediatric Patients

For infants and children especially, antihistamines in overdosage may cause hallucinations, convulsions, or death.

As in adults, antihistamines may diminish mental alertness in pediatric patients. In the young child, particularly, they may produce excitation (see CONTRAINDICATIONS ).

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PRECAUTIONS

General

Drowsiness may be experienced by some patients, especially with high dosage. This effect frequently is not undesirable in conditions for which the drug is used.

Information for Patients

Because of the potential for drowsiness, patients taking Dramin B-6 should be cautioned against operating automobiles or dangerous machinery (see WARNINGS ).

Carcinogenesis, Mutagenesis, Impairment of Fertility

Mutagenicity screening tests performed with Dramin B-6 (Dimenhydrinate), diphenhydramine, and 8-chlorotheophylline produced positive results in the bacterial systems and negative results in the mammalian systems. There are no human data that indicate Dramin B-6 (Dimenhydrinate) is a carcinogen or mutagen or that it impairs fertility.

Pregnancy

Pregnancy Category B.

Reproduction studies have been performed in rats at doses up to 20 times the human dose, and in rabbits at doses up to 25 times the human dose, and have revealed no evidence of impaired fertility or harm to the fetus due to Dramin B-6 (Dimenhydrinate). There are no adequate and well-controlled studies in pregnant women. However, clinical studies in pregnant women have not indicated that Dramin B-6 (Dimenhydrinate) increases the risk of abnormalities when administered in any trimester of pregnancy. It would appear that the possibility of fetal harm is remote when the drug is used during pregnancy. Nevertheless, because the studies in humans cannot rule out the possibility of harm, Dramin B-6 (Dimenhydrinate) should be used during pregnancy only if clearly needed.

Labor and Delivery

The safety of Dramin B-6 (Dimenhydrinate) given during labor and delivery has not been established. Reports have indicated Dramin B-6 (Dimenhydrinate) may have an oxytocic effect. Caution is advised when this effect is unwanted or in situations where it may prove detrimental.

Nursing Mothers

Small amounts of Dramin B-6 (Dimenhydrinate) are excreted in breast milk. Because of the potential for adverse reactions in nursing infants from Dramin B-6 (Dimenhydrinate), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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ADVERSE REACTIONS

The most frequent adverse reaction to Dramin B-6 (Dimenhydrinate) is drowsiness. Dizziness may also occur. Symptoms of dry mouth, nose and throat, blurred vision, difficult or painful urination, headache, anorexia, nervousness, restlessness or insomnia (especially in pediatric patients), skin rash, thickening of bronchial secretions, tachycardia, epigastric distress, lassitude, excitation, and nausea have been reported.

OVERDOSAGE

Drowsiness is the usual clinical side effect. Convulsions, coma, and respiratory depression may occur with massive overdosage. No specific antidote is known. If respiratory depression occurs, mechanically assisted respiration should be initiated and oxygen should be administered. Convulsions should be treated with appropriate doses of diazepam. Phenobarbital (5 to 6 mg/kg) may be given to control convulsions in pediatric patients.

The oral LD50 in mice and rats is 203 mg/kg and 1320 mg/kg, respectively. The intraperitoneal LD50 in mice is 149 mg/kg.

DOSAGE AND ADMINISTRATION

Dramin B-6 in the injectable form is indicated when the oral form is impractical.

Adults

Nausea or vomiting may be expected to be controlled for approximately 4 hours with 50 mg, and prevented by a similar dose every 4 hours. Its administration may be attended by some degree of drowsiness in some patients, and 100 mg every 4 hours may be given in conditions in which drowsiness is not objectionable or is even desirable.

For intramuscular administration, each milliliter (50 mg) of solution is injected as needed, but for intravenous administration, each milliliter (50 mg) of solution must be diluted in 10 mL of 0.9% Sodium Chloride Injection, USP and injected over a period of 2 minutes.

Pediatric

For intramuscular administration, 1.25 mg/kg of body weight or 37.5 mg/m2 of body surface area is administered four times daily. The maximum dose should not exceed 300 mg daily (see CONTRAINDICATIONS ).

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

HOW SUPPLIED

Dramin B-6 (Dimenhydrinate) Injection, USP, 50 mg/mL is available in multiple dose amber vials, as follows:


Product

No.


NDC

No.


Strength


Vial Size


361601


63323-366-01


50 mg/mL


1 mL in 2 mL vial, in packages of 25.


361610


63323-366-10


50 mg/mL


10 mL in a 10 mL vial, packaged individually.


Protect from light.

Store at 20° to 25°C (68° to 77°F).

Vial stoppers do not contain natural rubber latex.

45981B

Revised: April 2008

logo PACKAGE LABEL - PRINCIPAL DISPLAY - Dramin B-6 (Dimenhydrinate) 1 mL Vial Label

NDC 63323-366-01

361601

Dramin B-6 (Dimenhydrinate) INJECTION, USP

50 mg/mL

For IM Use

For IV Use: See package insert.

Rx only

1 mL Multiple Dose Vial



PACKAGE LABEL - PRINCIPAL DISPLAY - Dramin B-6 (Dimenhydrinate) 1 mL Tray Label

NDC 63323-366-01

361601

Dramin B-6 (Dimenhydrinate) INJECTION, USP

50 mg/mL

For IM Use

*For IV Use

Rx only

1 mL Multiple Dose Vial




361601vial 361601-tray

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Dramin B-6 pharmaceutical active ingredients containing related brand and generic drugs:


Dramin B-6 available forms, composition, doses:


Dramin B-6 destination | category:


Dramin B-6 Anatomical Therapeutic Chemical codes:


Dramin B-6 pharmaceutical companies:


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References

  1. Dailymed."DIMENHYDRINATE INJECTION, SOLUTION [APP PHARMACEUTICALS, LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Dramin B-6?

Depending on the reaction of the Dramin B-6 after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Dramin B-6 not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Dramin B-6 addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Dramin B-6, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Dramin B-6 consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

Visitor reported frequency of use

No survey data has been collected yet

One visitor reported doses

What is the dose of Dramin B-6 drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
11-50mg1
100.0%

Visitor reported time for results

No survey data has been collected yet

Visitor reported administration

No survey data has been collected yet

One visitor reported age

Visitors%
30-451
100.0%

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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