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Dormin uses

Pharmacological action

Dormin is an hypnotic drug from benzodiazepines group. This medication has a marked sedative effect, anxiolytic, sedative, anticonvulsant and central muscle relaxant effect. The mechanism of action is associated with increased inhibitory effect of GABA in the CNS by increasing the sensitivity of the GABA-receptor mediator as a result of stimulation of benzodiazepine receptors. Dormin increases the depth and duration of sleep. Sleep usually occurs in 20-40 minutes after ingestion and lasts for 6-8 hours. Moderately inhibits the phase of the quick sleep.


The plasma protein binding is more than 80%. Vd is 1.9 L / kg. T1/2 is an average of 26 hours. Dormin is excreted mainly as metabolites.

Why is Dormin prescribed?

Sleep disorders of various origins, somnambulism, premedication before surgery, encephalopathy, accompanied by epileptic seizures.

Dosage and administration

The daily dose for adults is ranged from 2.5 mg to 25 mg; the multiplicity of usind is set individually. The daily dose for children is 0.6-1 mg.

Dormin side effects, adverse reactions

CNS and peripheral nervous system: fatigue, impaired concentration, psychomotor retardation reactions, muscle weakness; rarely - headaches, ataxia, confusion, amnesia, depression, blurred vision, in predisposed patients may be worsening of suicidal thoughts, hallucinations.

Cardiovascular system: rarely - hypotension.

Digestive system: rarely - dry mouth, nausea, diarrhea.

Respiratory system: patients with obstructive pulmonary disease possible respiratory depression.

Reproductive system: changes in libido.

Allergic reactions: seldom - a skin rash, itching.

Dormin contraindications

Acute respiratory failure, drug or alcohol dependence, myasthenia gravis, temporal lobe epilepsy, angle-closure glaucoma, acute intoxication with drugs, providing a depressing effect on the central nervous system or alcohol abuse, hypersensitivity to benzodiazepines.


Using during pregnancy and breastfeeding

There was not conducted adequate and well-controlled studies safety of Dormin during pregnancy and lactation. Dormin is contraindicated especially in I and III trimester of pregnancy.

If necessary Dormin using during lactation breastfeeding should be discontinued.

Special instructions

Dormin should be used with caution in severe respiratory failure, obstructive pulmonary disease, ataxia, sleep apnea, marked hepatic dysfunction.

With prolonged use may develop drug dependence.

During the period of treatment avoid taking alcohol.

During the period of treatment patients should refrain from activities potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Dormin drug interactions

Simultaneous administration of Dormin with:

  • drugs providing a depressing effect on the CNS, with ethanol, ethanol containing drugs is enhanced inhibitory effect on the CNS.
  • anticonvulsant drugs may mutual enhancement of toxic effects.
  • Dormin potentiates the action of antihypertensive drugs.
  • estrogen containing oral contraceptives increases the concentration in blood plasma Dormin.
  • probenecid may interfere with the glucuronide binding of Dormin that leads to an increase in its concentration in plasma and by enhancing the therapeutic effect may develop excessive sedation.
  • rifampicin increased excretion from the body of Dormin
  • cimetidine increases the concentration of nitrazepama in blood plasma, which may be accompanied by increased sedation. It may be slow the hepatic metabolism of Dormin. This can lead to a lengthening of T1/2 of Dormin and for long-term use - an increase of its concentration in blood plasma.

    Dormin in case of emergency / overdose

    Symptoms: CNS depression of varying severity - lethargy, weakness, severe drowsiness, deep sleep, confusion, decreased response to painful stimuli; in more severe cases - ataxia, areflexia, hypotension, respiratory depression and cardiac activity, coma.

    Treatment: induction of vomiting or gastric lavage, activated charcoal technique, monitoring vital signs, symptomatic therapy, intravenous fluids, if necessary - mechanical ventilation. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital).


    Dormin pharmaceutical active ingredients containing related brand and generic drugs:

    infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

    Dormin available forms, composition, doses:

    infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

    Dormin destination | category:

    infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

    Dormin Anatomical Therapeutic Chemical codes:

    infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

    Dormin pharmaceutical companies:

    infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



    1. "nitrazepam". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    2. "nitrazepam". http://www.drugbank.ca/drugs/DB0159... (accessed August 28, 2018).
    3. "9CLV70W7HS: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Dat... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Dormin?

    Depending on the reaction of the Dormin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Dormin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Dormin addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.



    sDrugs.com conducted a study on Dormin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Dormin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the sDrugs.com website users shows the following figures about several people who felt the medicine Dormin is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.

    One visitor reported doses

    What is the dose of Dormin drug you are taking?
    According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

    Two visitors reported age


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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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