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DRUGS & SUPPLEMENTS
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When are you taking this medicine? |
Atropine Sulfate:
Indication: For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides.
Donnagel (Atropine Sulfate), a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Donnagel (Atropine Sulfate) is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of Donnagel (Atropine Sulfate) abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Donnagel (Atropine Sulfate) may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Donnagel (Atropine Sulfate) in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, Donnagel (Atropine Sulfate) does not exert a striking or uniform effect on blood vessels or blood pressure.
Hyoscyamine Sulfate:
Donnagel (Hyoscyamine Sulfate) is indicated for the treatment of symptoms of irritative voiding. Indicated for the relief of local symptoms, such as inflammation, hypermotility, and pain, which accompany lower urinary tract infections. Indicated for the relief of urinary tract symptoms caused by diagnostic procedures..
Donnagel (Hyoscyamine Sulfate) is contraindicated in patients with a hypersensitivity to any of the ingredients. Risk- benefit should be considered when the following medical problems exist: Cardiac disease (especially cardiac arrhythmias, congestive heart failure, coronary heart disease, and mitral stenosis); gastrointestinal tract obstructive disease; glaucoma; myasthenia gravis; acute urinary retention may be precipitated in obstructive uropathy (such as bladder neck obstruction due to prostatic hypertrophy).
Do not exceed recommended dosage. If rapid pulse, dizziness, or blurring of vision occurs, discontinue use immediately.
Patients should be advised that urine will be colored blue when taking this medication. Do not exceed recommended dosage.
Contains Methylene Blue and should NOT be taken with serotonergic psychiatric medications.
Cross sensitivity and/or related problems:
Patients intolerant of other belladonna alkaloids or other salicylates may be intolerant of this medication also. Delay in gastric emptying could complicate the management of gastric ulcers.
Although the exact mechanism of this drug interaction is unknown, methylene blue inhibits the action of monoamine oxidase A- an enzyme responsible for breaking down serotonin in the brain. It is believed that when methylene blue is given to patients taking serotonergic psychiatric medications, high levels of serotonin can build up in the brain, causing toxicity. This is referred to as Serotonin Syndrome. Signs and symptoms of Serotonin Syndrome include mental changes, muscle twitching, excessive sweating, shivering or shaking, diarrhea, trouble with coordination, and/or fever.
Methylene blue can interact with serotonergic psychiatric medications and cause serious CNS toxicity.
In emergency situations requiring life-threatening or urgent treatment with methylene blue (as described above), the availability of alternative interventions should be considered and the benefit of methylene blue treatment should be weighed against the risk of serotonin toxicity. If methylene blue must be administered to a patient receiving a serotonergic drug, the serotonergic drug must be immediately stopped, and the patient should be closely monitored for emergent symptoms of CNS toxicity for two weeks (five weeks if fluoxetine [Prozac] was taken), or until 24 hours after the last dose of methylene blue, whichever comes first.
In non-emergency situations when non-urgent treatment with methylene blue is contemplated and planned, the serotonergic psychiatric medication should be stopped to allow its activity in the brain to dissipate. Most serotonergic psychiatric drugs should be stopped at least 2 weeks in advance of methylene blue treatment. Fluoxetine (Prozac), which has a longer half-life compared to similar drugs, should be stopped at least 5 weeks in advance.
Treatment with the serotonergic psychiatric medication may be resumed 24 hours after the last dose of methylene blue.
Serotonergic psychiatric medications should not be started in a patient receiving methylene blue. Wait until 24 hours after the last dose of methylene blue before starting the antidepressant.
Educate your patients to recognize the symptoms of serotonin toxicity or CNS toxicity and advise them to contact a healthcare professional immediately if they experience any symptoms while taking serotonergic psychiatric medications or methylene blue.
As a result of hyoscyamine's effects on gastrointestinal motility and gastric emptying, absorption of other oral medications may be decreased during concurrent use with this combination medication.
May cause the urine to become alkaline reducing the effectiveness of methenamine by inhibiting its conversion to formaldehyde.
Concurrent use may intensify antimuscarinic effects of Donnagel because of secondary antimuscarinic activities of these medications.
Concurrent use may reduce absorption of Donnagel (Hyoscyamine Sulfate) resulting in decreased therapeutic effectiveness. Concurrent use with antacids may cause urine to become alkaline reducing the effectiveness of methenamine by inhibiting its conversion to formaldehyde. Doses of these medications should be spaced 1 hour apart from doses of Donnagel (Hyoscyamine Sulfate).
Concurrent use with Donnagel may further reduce intestinal motility, therefore, caution is recommended.
Ketoconazole and Donnagel (Hyoscyamine Sulfate) may cause increased gastrointestinal pH. Concurrent administration with Donnagel (Hyoscyamine Sulfate) may result in marked reduction in the absorption of ketoconazole. Patients should be advised to take this combination at least 2 hours after ketoconazole.
Concurrent use with Donnagel (Hyoscyamine Sulfate) may intensify antimuscarinic side effects.
Opioid (narcotic) analgesics may result in increased risk of severe constipation.
These drugs may precipitate with formaldehyde in the urine increasing the danger of crystalluria.
Patients should be advised that the urine and/or stools may become blue to blue-green as a result of the excretion of methylene blue.
Donnagel (Hyoscyamine Sulfate) and methenamine cross the placenta. Studies have not been done in either animals or humans. It is not known whether Donnagel (Hyoscyamine Sulfate) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Donnagel (Hyoscyamine Sulfate) should be given to a pregnant woman only if clearly needed.
Methenamine and traces of Donnagel are excreted in breast milk. Caution should be exercised when Donnagel (Hyoscyamine Sulfate) is administered to a nursing mother.
There have been no studies to establish the safety of prolonged use in humans. No known long-term animal studies have been performed to evaluate carcinogenic potential.
Infants and young children are especially susceptible to the toxic effect of the belladonna alkaloids.
Use with caution in elderly patients as they may respond to the usual doses of the belladonna alkaloids with excitement, agitation, drowsiness, or confusion.
Cardiovascular - rapid pulse, flushing
Central Nervous System - blurred vision, dizziness, drowsiness
Respiratory - shortness of breath or troubled breathing
Genitourinary - difficult micturition, acute urinary retention
Gastrointestinal - dry mouth, nausea and vomiting
Serious allergic reactions to this drug are rare. Seek immediate medical attention if you notice symptoms of a serious allergic reaction, including itching, rash, severe dizziness, swelling or trouble breathing.
This medication can cause urine and sometimes stools to turn blue to blue-green. This effect is harmless and will subside after medication is stopped.
Call your doctor or physician for medical advice about side effects. To report SUSPECTED ADVERSE REACTIONS, contact Burel Pharmaceuticals, Inc at 1-601-706-9819 or FDA at 1-800-FDA-1088, www.fda.gov/medwatch.
A dependence on the use of Donnagel (Hyoscyamine Sulfate) has not been reported and due to the nature of its ingredients, abuse of Donnagel (Hyoscyamine Sulfate) is not expected.
Emesis or gastric lavage. Slow intravenous administration of physostigmine in doses of 1 to 4 mg (0.5 to 1 mg in children) repeated as needed in one to two hours to reverse severe antimuscarinic symptoms.
Administration of small doses of diazepam to control excitement and seizures. Artificial respiration with oxygen if needed for respiratory depression. Adequate hydration.
Symptomatic treatment as necessary.
If overdose is suspected, contact the poison control center at 1-800-222-1222, or your local emergency room immediately
Adults: One tablet orally 4 times per day followed by liberal fluid intake.
Pediatric: Dosage must be individualized by physician for older children. Not recommended for use in children six years of age or younger.
Donnagel (Hyoscyamine Sulfate) are blue tablets, oval, biconvex, debossed with “BL 07” with scoreline on one side and plain on the other side, available in bottles of 100 tablets, NDC 35573-307-10.
Store in a cool, dry place at controlled room temperature 15° to 30°C (59° to 86°F). Keep container tightly closed. Protect from moisture and direct sunlight.
Dispense in a tight, light-resistant container as defined in the USP/NF with a child resistant closure.
KEEP OUT OF THE REACH OF CHILDREN.
IN CASE OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE OR CONTACT A POISON CONTROL CENTER IMMEDIATELY.
Note: Patients should be advised that urine will be colored blue when taking this medication.
Rx Only
Manufactured for:
Burel Pharmaceuticals, Inc
Richland, MS 39218
Rev. 7/2015
NDC 35573-307-10
Donnagel (Hyoscyamine Sulfate) ®
URINARY ANTISEPTIC
Each Tablet Contains:
Methenamine | 81.6 mg |
Benzoic Acid | 9.0 mg |
Phenyl Salicylate | 36.2 |
Methylene Blue | 10.8 mg |
Donnagel (Hyoscyamine Sulfate) Sulfate | 0.12 mg |
Rx ONLY
Buruel Pharmaceuticals
100 Tablets
Donnagel (Hyoscyamine Sulfate) is a trademark of Burel Pharmaceuticals, Inc
Manufactured for:
Burel Pharmaceuticals, Inc
Richland, MS 39218
Kaolin:
Anti-Diarrheal Liquid
For Animal Use Only
Keep Out of Reach of Children
NET CONTENTS:
1 GALLON (3.785L)
ASPEN
VETERINARY RESOURCES, Ltd.
For oral administration as an aid in the treatment of noninfectious diarrhea in horses, cattle, dogs and cats.
Administer orally after first sign of diarrhea and after each loose bowel movement, or as needed.
Cattle and Horses: 6 to 10 fl oz
Calves and Foals: 3 to 4 fl oz
Dogs and Cats: 1 to 3 tablespoonfuls
If symptoms persist after using this product for 2 to 3 days, consult your veterinarian.
TAKE TIME OBSERVE LABEL DIRECTIONS
Kaolin ... 90 gr. (5.8 g)
Pectin ... 4 gr. (0.268 g)
In a palatable vehicle.
Flavorings and color added.
Store at controlled room temperature between 15º and 30ºC (59º - 86ºF).
Protect from freezing.
SHAKE WELL BEFORE USING.
Restriced Drug.
Use only as directed.
Not for human use.
Manufactured for:
Aspen Veterinary Resources, R Ltd.
Liberty, MO 64068
A316AP 12/11
Lot No. Exp. Date
Pectin:
Drug Facts
Donnagel (Pectin) 5.4 mg
Oral demulcent
For temporary relief of minor discomfort and protection of irritated areas in sore mouth and sore throat.
Sore throat warning: if sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, swelling, nausea or vomiting, consult a doctor promptly. These may be serious.
- sore mouth does not improve in 7 days
- irritation, pain or redness persists or worsens
- adults and children 3 years of age and older: allow one pop to dissolve slowly in mouth
- May be repeated as needed or as directed by a doctor
- Children under 3 years of age: ask a doctor
Store at 20°-25°C (68°-77°F) in a dry place
caramel color, corn syrup, honey, natural flavor, sucrose, water
Mon.-Fri. 8 am to 8 pm EST
LittleRemedies.com
Scopolamine Hydrobromide:
Indication: For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.
Donnagel (Scopolamine Hydrobromide) is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Donnagel (Scopolamine Hydrobromide) has many uses including the prevention of motion sickness. It is not clear how Donnagel (Scopolamine Hydrobromide) prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Donnagel (Scopolamine Hydrobromide) prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Donnagel (Scopolamine Hydrobromide) also may work directly on the vomiting center. Donnagel (Scopolamine Hydrobromide) must be taken before the onset of motion sickness to be effective.
Depending on the reaction of the Donnagel after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Donnagel not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Donnagel addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology