Diazolen

What do you feel about the cost of the medicine? Is it expensive?  No   Yes

Diazolen uses

• Pharmacological action
• Pharmacokinetics
• Why is Diazolen prescribed?
• Dosage and administration
• Diazolen side effects, adverse reactions
• Diazolen contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Diazolen drug interactions
• Diazolen in case of emergency / overdose
• Diazolen reviews

Pharmacological action

Diazolen is a worming medication a broad spectrum of action, it is most effective when enterobioze. This drug causes irreversible disturbance of glucose utilization in the body of the worm and inhibits the synthesis of ATP.

Pharmacokinetics

Diazolen is practically not absorbed from the gastrointestinal tract. The plasma protein binding is 90%. This medication is distributed unevenly in organs and accumulates in adipose tissue, liver, and larvae of helminths. Diazolen is metabolized in the liver to 2-amino derivative.

T_1/2 is 2.5-5.5 hours. More than 90% of the dose is excreted unchanged in feces. Grown deep portion is excreted by kidneys.

Why is Diazolen prescribed?

Enterobiasis, ascariasis, hookworm disease, strongyloidiasis, trichuriasis, trichinosis, teniasis, echinococcosis, mixed helminth infections.

Dosage and administration

For adults and children over 10 years at enterobioze a single dose is 100 mg.

For children aged 2 to 10 years a single dose is 25-50 mg. In the case of a high probability of re-infestation the drug taking repeats after 2-4 weeks in the same dose.

It is recommended that simultaneous treatment of all family members.

When ascariasis, trichuriasis, hookworm disease, teniasis, strongyloidiasis and mixed helminthiasis - 100 mg in the morning and evening for 3 days. When trichinosis - 200-400 mg 3 times / day for 3 days, from 4th to 10th day - 400-500 mg 3 times / day. When echinococcosis - 500 mg 2 times / day in the first 3 days, then the same dose 3 times / day in the next 3 days. Later Diazolen used in doses of 25-30 mg / kg / day in 3-4 doses.

Diazolen side effects, adverse reactions

Digestive system: rarely - nausea, abdominal pain; when used in high doses for long periods of time may be vomiting, diarrhea, transient elevation of liver enzymes in serum.

CNS: Rarely - dizziness when used in high doses for long periods of time - a headache.

Hematopoietic system: when used in high doses for long periods of time may be leukopenia, anemia, eosinophilia.

Urinary system: when used in high doses for long periods of time - hematuria, cylindruria.

Other: when used in high doses for long periods of time - an allergic reaction, hair loss.

Diazolen contraindications

Pronounced liver disfunctions, pregnancy, lactation, children under 2 years of age, hypersensitivity to Diazolen.

Using during pregnancy and breastfeeding

Diazolen is contraindicated during pregnancy and lactation (breastfeeding).

Category of the fetus by FDA - C.

Special instructions

With prolonged use of Diazolen it is necessary to control the peripheral blood picture, liver and kidney function.

Within days after taking Diazolen avoid drinking alcohol.

After receiving Diazolen do not use a laxative.

It is mandatory a periodic examination of smears of the anal region and the feces after treatment.

Diazolen drug interactions

Diazolen reduces insulin requirements in diabetic patients.

It is necessary to avoid a simultaneously taking of Diazolen with lipophilic substances. With simultaneous use with cimetidine it may increase, and carbamazepine, and other inducers of metabolism to reduce the concentration of Diazolen in the blood.

Diazolen in case of emergency / overdose

Symptoms: nausea, vomiting, diarrhea, abdominal pain. With prolonged use at high doses: reversible hepatic dysfunction, hepatitis, neutropenia.

Treatment: gastric lavage, enemas, activated charcoal method; there is no specific antidote.

Diazolen pharmaceutical active ingredients containing related brand and generic drugs:

• Mebendazole

Diazolen available forms, composition, doses:

• N/A

Diazolen destination | category:

• Human:
• Anthelmintics

Diazolen Anatomical Therapeutic Chemical codes:

• P02CA01 - Mebendazole

Diazolen pharmaceutical companies:

• Degort's Chemical

References

1. Dailymed."VERMOX (MEBENDAZOLE) TABLET, CHEWABLE [JANSSEN PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
2. Dailymed."MEBENDAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
3. "mebendazole". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Depending on the reaction of the Diazolen after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Diazolen not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

Review

Visitor reports

Visitor reviews

The information was verified by Dr. Rachana Salvi, MD Pharmacology