DRUGS & SUPPLEMENTS

Dextrose 5% and Sodium Chloride 0.45%

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Dextrose 5% and Sodium Chloride 0.45% uses


INDICATIONS AND USAGE

Intravenous solutions containing Dextrose 5% and Sodium Chloride 0.45% are indicated for parenteral replenishment of fluid, minimal carbohydrate calories, and sodium chloride as required by the clinical condition of the patient.

CONTRAINDICATIONS

None known.

WARNINGS

Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention.

Excessive administration of potassium-free solutions may result in significant hypokalemia.

In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention.

The intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema.

The risk of dilutional states is inversely proportional to the electrolyte concentrations of administered parenteral solutions. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of such solutions.

PRECAUTIONS

Clinical evaluation and periodic laboratory determinations are necessary to monitor changes in fluid balance, electrolyte concentrations and acid-base balance during prolonged parenteral therapy or whenever the condition of the patient warrants such evaluation.

Solutions containing dextrose should be used with caution in patients with known subclinical or overt diabetes mellitus.

Caution must be exercised in the administration of parenteral fluids, especially those containing sodium ions to patients receiving corticosteroids or corticotropin.

Do not administer unless solution is clear and container is undamaged. Discard unused portion.

Pregnancy Category C. Animal reproduction studies have not been conducted with dextrose or sodium chloride. It is also not known whether dextrose or sodium chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Dextrose or sodium chloride should be given to a pregnant woman only if clearly needed.

Pediatric Use. The safety and effectiveness in the pediatric population are based on the similarity of the clinical conditions of the pediatric and adult populations. In neonates or very small infants, the volume of fluid may affect fluid and electrolyte balance.

Frequent monitoring of serum glucose concentrations is required when dextrose is prescribed to pediatric patients, particularly neonates and low birth weight infants.

In very low birth weight infants, excessive or rapid administration of dextrose injection may result in increased serum osmolality and possible intracerebral hemorrhage.

Geriatric Use. An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Sodium ions are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

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ADVERSE REACTIONS

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

OVERDOSAGE

In the event of overhydration or solute overload, re-evaluate the patient and institute appropriate corrective measures. See WARNINGS , PRECAUTIONS , and ADVERSE REACTIONS .

DOSAGE AND ADMINISTRATION

The dose is dependent upon the age, weight and clinical condition of the patient.

As reported in the literature, the dosage and constant infusion rate of intravenous dextrose must be selected with caution in pediatric patients, particularly neonates and low birth weight infants, because of the increased risk of hyperglycemia/hypoglycemia.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS .

Drug Interactions

Additives may be incompatible. Consult with pharmacist, if available. When introducing additives, use aseptic technique, mix thoroughly and do not store.

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INSTRUCTIONS FOR USE

To Open:

Tear outer wrap at notch and remove solution container. If supplemental medication is desired, follow directions below before preparing for administration.

To Add Medication

  • Prepare additive port.
  • Using aseptic technique and an additive delivery needle of appropriate length, puncture resealable additive port at target area, inner diaphragm and inject. Withdraw needle after injecting medication.
  • The additive port may be protected by covering with an additive cap.
  • Mix container contents thoroughly.

Preparation for Administration

(Use aseptic technique)

  • Close flow control clamp of administration set.
  • Remove cover from outlet port at bottom of container.
  • Insert piercing pin of administration set into port with a twisting motion until the set is firmly seated. NOTE: When using a vented administration set, replace bacterial retentive air filter with piercing pin cover. Insert piercing pin with twisting motion until shoulder of air filter housing rests against the outlet port flange.
  • Suspend container from hanger.
  • Squeeze and release drip chamber to establish proper fluid level in chamber.
  • Attach venipuncture device to set.
  • Open clamp to expel air from set and venipuncture device. Close clamp.
  • Perform venipuncture.
  • Regulate rate of administration with flow control clamp.

WARNING: Do not use flexible container in series connections.

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HOW SUPPLIED

Dextrose 5% and Sodium Chloride 0.45% Injection, USP are supplied in single-dose flexible plastic containers in various sizes and concentrations as shown in the accompanying Table.


Grams/100 mL


Per 1000 mL


NDC No.


Product


Dextrose

(hydrous)


Sodium

Chloride


Sodium

Na+


Chloride

Cl¯


Caloric

Value


Tonicity


Osmolarity mOsmol/L (calc)


pH


Container

size (mL)


0409-7924-02


5% Dextrose and 0.225% Sodium Chloride Inj., USP


5


0.225


38.5 mEq


38.5 mEq


170


Hypertonic


329


4.3 (3.5 to 6.5)


250


0409-7924-03


5% Dextrose and 0.225% Sodium Chloride Inj., USP


5


0.225


38.5 mEq


38.5 mEq


170


Hypertonic


329


4.3 (3.5 to 6.5)


500


0409-7924-09


5% Dextrose and 0.225% Sodium Chloride Inj., USP


5


0.225


38.5 mEq


38.5 mEq


170


Hypertonic


329


4.3 (3.5 to 6.5)


1000


0409-7925-02


5% Dextrose and 0.3% Sodium Chloride Inj., USP


5


0.3


51 mEq


51 mEq


170


Hypertonic


355


4.3 (3.5 to 6.5)


250


0409-7925-03


5% Dextrose and 0.3% Sodium Chloride Inj., USP


5


0.3


51 mEq


51 mEq


170


Hypertonic


355


4.3 (3.5 to 6.5)


500


0409-7925-09


5% Dextrose and 0.3% Sodium Chloride Inj., USP


5


0.3


51 mEq


51 mEq


170


Hypertonic


355


4.3 (3.5 to 6.5)


1000


0409-7926-02


5% Dextrose and 0.45% Sodium Chloride Inj., USP


5


0.45


77 mEq


77 mEq


170


Hypertonic


406


4.3 (3.5 to 6.5)


250


0409-7926-03


5% Dextrose and 0.45% Sodium Chloride Inj., USP


5


0.45


77 mEq


77 mEq


170


Hypertonic


406


4.3 (3.5 to 6.5)


500


0409-7926-09


5% Dextrose and 0.45% Sodium Chloride Inj., USP


5


0.45


77 mEq


77 mEq


170


Hypertonic


406


4.3 (3.5 to 6.5)


1000


0409-7941-02


5% Dextrose and 0.9% Sodium Chloride Inj., USP


5


0.9


154 mEq


154 mEq


170


Hypertonic


560


4.3 (3.5 to 6.5)


250


0409-7941-03


5% Dextrose and 0.9% Sodium Chloride Inj., USP


5


0.9


154 mEq


154 mEq


170


Hypertonic


560


4.3 (3.5 to 6.5)


500


0409-7941-09


5% Dextrose and 0.9% Sodium Chloride Inj., USP


5


0.9


154 mEq


154 mEq


170


Hypertonic


560


4.3 (3.5 to 6.5)


1000


Protect from freezing. Store at 20 to 25°C (68 to 77°F).

Revised: June, 2009

Printed in USA                                                     EN-2179

Hospira, Inc., Lake Forest, IL 60045 USA

1000 mL

NDC 0409-7924-09

5% DEXTROSE

and 0.225%

SODIUM CHLORIDE

Injection, USP

EACH 100 mL CONTAINS DEXTROSE,

HYDROUS 5 g; SODIUM CHLORIDE

225 mg IN WATER FOR INJECTION.

ELECTROLYTES PER 1000 mL: SODIUM

38.5 mEq; CHLORIDE 38.5 mEq.

329 mOsmol/LITER (CALC).

pH 4.3 (3.5 to 6.5).

ADDITIVES MAY BE INCOMPATIBLE.

CONSULT WITH PHARMACIST, IF

AVAILABLE. WHEN INTRODUCING

ADDITIVES, USE ASEPTIC TECHNIQUE,

MIX THOROUGHLY AND DO NOT STORE.

SINGLE-DOSE CONTAINER. FOR I.V. USE.

USUAL

Dosage: SEE INSERT. STERILE,

NONPYROGENIC. USE ONLY IF

SOLUTION IS CLEAR AND CONTAINER IS

UNDAMAGED. MUST NOT BE USED IN

SERIES CONNECTIONS.

Rx ONLY

3

v

CONTAINS DEHP

Hospira

©HOSPIRA 2004

IM-0159 (10/04)

PRINTED IN USA

HOSPIRA, INC., LAKE FOREST, IL 60045 USA

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Dextrose 5% and Sodium Chloride 0.45% pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Dextrose 5% and Sodium Chloride 0.45% available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Dextrose 5% and Sodium Chloride 0.45% destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Dextrose 5% and Sodium Chloride 0.45% Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Dextrose 5% and Sodium Chloride 0.45% pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."DEXTROSE 50% (DEXTROSE MONOHYDRATE) LIQUID [RADIX LABORATORIES, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."NASAL SPA NATURAL SEA SALT (SODIUM CHLORIDE) SPRAY [NACUR HEALTHCARE LTD]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. Dailymed."AMINO ACIDS; CALCIUM ACETATE; GLYCERIN; MAGNESIUM ACETATE; PHOSPHORIC ACID; POTASSIUM CHLORIDE; SODIUM ACETATE; SODIUM CHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Dextrose 5% and Sodium Chloride 0.45%?

Depending on the reaction of the Dextrose 5% and Sodium Chloride 0.45% after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Dextrose 5% and Sodium Chloride 0.45% not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Dextrose 5% and Sodium Chloride 0.45% addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Dextrose 5% and Sodium Chloride 0.45%, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Dextrose 5% and Sodium Chloride 0.45% consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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