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DRUGS & SUPPLEMENTS
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Decolsin Reformulated
What are the side effects you encounter while taking this medicine? |
Decolsin Reformulated uses
Decolsin Reformulated consists of Acetaminophen, Dextromethorphan Hydrobromide, Phenylpropanolamine Hydrochloride.Acetaminophen:
Pharmacological action
Decolsin Reformulated is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Why is Decolsin Reformulated (Acetaminophen) prescribed?
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Decolsin Reformulated dosage and administration
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Decolsin Reformulated side effects, adverse reactions
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Contraindications
Chronic active alcoholism, increased sensitivity to Decolsin Reformulated, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Using during pregnancy and breastfeeding
Decolsin Reformulated (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Decolsin Reformulated (Acetaminophen) on the fetus in humans.
Decolsin Reformulated (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Decolsin Reformulated (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Decolsin Reformulated (Acetaminophen).
Special Instructions
Decolsin Reformulated is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Decolsin Reformulated (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
Decolsin Reformulated (Acetaminophen) Drug Interactions
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Decolsin Reformulated (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Decolsin Reformulated (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Decolsin Reformulated (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Decolsin Reformulated (Acetaminophen).
When Decolsin Reformulated (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Decolsin Reformulated (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Decolsin Reformulated (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Decolsin Reformulated (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Decolsin Reformulated (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Decolsin Reformulated (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Decolsin Reformulated (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Decolsin Reformulated (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Decolsin Reformulated (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Decolsin Reformulated (Acetaminophen) with ethinylestradiol increases absorption of Decolsin Reformulated (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Decolsin Reformulated in case of emergency / overdose
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Dextromethorphan Hydrobromide:
Pharmacological action
Decolsin Reformulated is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Decolsin Reformulated (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. Decolsin Reformulated (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Decolsin Reformulated (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Decolsin Reformulated (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Decolsin Reformulated (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.
Pharmacokinetics
After oral administration Decolsin Reformulated (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. Cmax of Decolsin Reformulated (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.
Why is Decolsin Reformulated prescribed?
Dry cough of different etiology.
Dosage and administration
For adults and children over 12 years Decolsin Reformulated prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.
Decolsin Reformulated (Dextromethorphan Hydrobromide) side effects, adverse reactions
Drowsiness, nausea, dizziness.
Decolsin Reformulated contraindications
Bronchial asthma, bronchitis, simultaneous reception of mucolytic.
Using during pregnancy and breastfeeding
During pregnancy and lactation (breastfeeding) Decolsin Reformulated (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.
Special instructions
With carefully administered Decolsin Reformulated (Dextromethorphan Hydrobromide) with impaired liver function.
Decolsin Reformulated drug interactions
MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Decolsin Reformulated (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Decolsin Reformulated (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
Decolsin Reformulated in case of emergency / overdose
Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.
Treatment: mechanical ventilation, symptomatic agents.
Phenylpropanolamine Hydrochloride:
Decolsin Reformulated (Phenylpropanolamine Hydrochloride) has been withdrawn in Canada. In November 2000, the Food and Drug Administration (FDA) issued a public health advisory against the use of the drug.
Indication: For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
Decolsin Reformulated (Phenylpropanolamine Hydrochloride) (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. Decolsin Reformulated (Phenylpropanolamine Hydrochloride) is found in appetite suppressant formulations and with guaifenesinin in cough-cold formulations. In 2000, the FDA requested that all drug companies discontinue marketing products containing Decolsin Reformulated (Phenylpropanolamine Hydrochloride), due to an increased risk of hemorrhagic stroke in women who used Decolsin Reformulated (Phenylpropanolamine Hydrochloride).
Decolsin Reformulated pharmaceutical active ingredients containing related brand and generic drugs:
Decolsin Reformulated available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.