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DRUGS & SUPPLEMENTS
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Contac Day and Night Cold and Flu
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Contac Day and Night Cold and Flu uses
Contac Day and Night Cold and Flu consists of Acetaminophen, Dextromethorphan Hydrobromide, Pseudoephedrine Hydrochloride.Acetaminophen:
Pharmacological action
Contac Day and Night Cold and Flu is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Why is Contac Day and Night Cold and Flu (Acetaminophen) prescribed?
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Contac Day and Night Cold and Flu dosage and administration
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Contac Day and Night Cold and Flu side effects, adverse reactions
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Contraindications
Chronic active alcoholism, increased sensitivity to Contac Day and Night Cold and Flu, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Using during pregnancy and breastfeeding
Contac Day and Night Cold and Flu (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Contac Day and Night Cold and Flu (Acetaminophen) on the fetus in humans.
Contac Day and Night Cold and Flu (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Contac Day and Night Cold and Flu (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Contac Day and Night Cold and Flu (Acetaminophen).
Special Instructions
Contac Day and Night Cold and Flu is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Contac Day and Night Cold and Flu (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
Contac Day and Night Cold and Flu (Acetaminophen) Drug Interactions
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Contac Day and Night Cold and Flu (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Contac Day and Night Cold and Flu (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Contac Day and Night Cold and Flu (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Contac Day and Night Cold and Flu (Acetaminophen).
When Contac Day and Night Cold and Flu (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Contac Day and Night Cold and Flu (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Contac Day and Night Cold and Flu (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Contac Day and Night Cold and Flu (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Contac Day and Night Cold and Flu (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Contac Day and Night Cold and Flu (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Contac Day and Night Cold and Flu (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Contac Day and Night Cold and Flu (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Contac Day and Night Cold and Flu (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Contac Day and Night Cold and Flu (Acetaminophen) with ethinylestradiol increases absorption of Contac Day and Night Cold and Flu (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Contac Day and Night Cold and Flu in case of emergency / overdose
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Dextromethorphan Hydrobromide:
Pharmacological action
Contac Day and Night Cold and Flu is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) has not addiction effects and it has no analgesic and hypnotic action. Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.
Pharmacokinetics
After oral administration Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) is completely absorbed from the gastrointestinal tract. Cmax of Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.
Why is Contac Day and Night Cold and Flu prescribed?
Dry cough of different etiology.
Dosage and administration
For adults and children over 12 years Contac Day and Night Cold and Flu prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.
Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) side effects, adverse reactions
Drowsiness, nausea, dizziness.
Contac Day and Night Cold and Flu contraindications
Bronchial asthma, bronchitis, simultaneous reception of mucolytic.
Using during pregnancy and breastfeeding
During pregnancy and lactation (breastfeeding) Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.
Special instructions
With carefully administered Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) with impaired liver function.
Contac Day and Night Cold and Flu drug interactions
MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Contac Day and Night Cold and Flu (Dextromethorphan Hydrobromide) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
Contac Day and Night Cold and Flu in case of emergency / overdose
Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.
Treatment: mechanical ventilation, symptomatic agents.
Pseudoephedrine Hydrochloride:
Active ingredients (in each caplet)...Purpose
Guaifenesin 400 mg...Expectorant
Contac Day and Night Cold and Flu (Pseudoephedrine Hydrochloride) hydrochloride 60 mg...Nasal decongestant
Uses
For temporarily relief of nasal congestion due to a cold, hay fever, or other upper respiratory allergies (allergic rhinitis), and to help loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive.
Uses
- temporarily relieves nasal congestion due to a cold, hay fever, or other upper respiratory allergies (allergic rhinitis).
- helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive.
Warnings
Do not exceed recommended dosage.
Do not use if you are taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for two weeks after stopping the MAOI. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Do not take this product for persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema, or where cough is accompanied by excessive phlegm (mucus) unless directed by a doctor.
A persistent cough may be a sign of a serious condition. If cough persists for more than 1 week, tends to recur, or is accompanied by fever, rash, or persistent headache, consult a doctor.
Ask a doctor before use if you have
- heart disease
- high blood pressure
- thyroid disease
- diabetes
- difficulty in urinating due to an enlarged prostate gland
Stop use and ask a doctor if
- you get nervous, dizzy, or sleepless
- symptoms do not improve within 7 days or are accompanied by fever
If pregnant or breast-feeding, ask a health professional before use.
Keep this and all drugs out of reach of children. In case of overdose, get medical help or contact a poison control center immediately.
Directions
- adults and children 12 years and older, 1 caplet every 4 to 6 hours, not more than 4 caplets in 24 hours
- children 6 to under 12 years, ½ caplet every 4 to 6 hours, not more than 2 caplets in 24 hours
- children under 6 years, consult a physician
Inactive ingredients
croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, sodium starch glycolate, and starch
Questions?
1-800-324-1880, 7:30am - 4:00pm Central, Mon.-Fri., or visit us at www.bfascher.com
Contac Day and Night Cold and Flu
Contac Day and Night Cold and Flu pharmaceutical active ingredients containing related brand and generic drugs:
Contac Day and Night Cold and Flu available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.